(n.) Blame; cause of blame; fault; crime; offense.
(n.) Deficiency; want; need; destitution; failure; as, a lack of sufficient food.
(v. t.) To blame; to find fault with.
(v. t.) To be without or destitute of; to want; to need.
(v. i.) To be wanting; often, impersonally, with of, meaning, to be less than, short, not quite, etc.
(v. i.) To be in want.
(interj.) Exclamation of regret or surprise.
Example Sentences:
(1) Here we have asked whether protection from blood-borne antigens afforded by the blood-brain barrier is related to the lack of MHC expression.
(2) tRNA from mutant IB13 lacks 5-methylaminomethyl-2-thio-uridine in vivo due to a permanently nonfunctional methyltransferase.
(3) BL6 mouse melanoma cells lack detectable H-2Kb and had low levels of expression of H-2Db Ag.
(4) Treatment termination due to lack of efficacy or combined insufficient therapeutic response and toxicity proved to be influenced by the initial disease activity and by the rank order of prescription.
(5) In the past, the interpretation of the medical findings was hampered by a lack of knowledge of normal anatomy and genital flora in the nonabused prepubertal child.
(6) A diplomatic source said the killing appeared particularly unusual because of Farooq lack of recent political activity: "He was lying low in the past two years.
(7) The present study examined whether the lack of chronic hemodynamic effects of ANP in control rats was due to changes in vascular reactivity to the peptide.
(8) Since it was established, it has stoked controversy about contemporary art, though in recent years it has been more notable for its lack of sensationalism.
(9) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(10) Because of the small number of patients reported in the world literature and lack of controlled studies, the treatment of small cell carcinoma of the larynx remains controversial; this retrospective analysis suggests that combination chemotherapy plus radiation offers the best chance for cure.
(11) I would immediately look askance at anyone who lacks the last and possesses the first.
(12) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(13) Core enzyme, lacking omega subunit, catalyzed this reaction at a rate less than 1% that of holoenzyme.
(14) But not only did it post a larger loss than expected, Amazon also projected 7% to 18% revenue growth over the busiest shopping period of the year, a far cry from the 20%-plus pace that had convinced investors to overlook its persistent lack of profit in the past.
(15) Urine specimens from patient REE also contained a light chain fragment that lacked the first (amino-terminal) 85 residues of the native light chain but otherwise was identical in sequence to the light chain REE.
(16) Thus the failure to raise anti-Id with internal image characteristics may provide an explanation for the lack of anti-gp120 activity reported in anti-Id antisera raised to multiple anti-CD4 antibodies.
(17) His walkout reportedly meant his fellow foreign affairs select committee members could not vote since they lacked a quorum.
(18) In South Africa, health risks associated with exposure to toxic waste sites need to be viewed in the context of current community health concerns, competing causes of disease and ill-health, and the relative lack of knowledge about environmental contamination and associated health effects.
(19) The functional capacity to present antigens to T cells was lacking in normal resting B cells, but was acquired following LK treatment.
(20) These findings indicate an association between HLA-B7 and ankylosing spondylitis in American blacks and suggest that these patients who lack B27 but possess B7 represent a subgroup of patients with this disease.
Unwieldy
Definition:
(a.) Not easily wielded or carried; unmanageable; bulky; ponderous.
Example Sentences:
(1) But he warned that the BBC’s in-house production department was an “unwieldy beast” and said it would have to adapt if it was going to compete head to head with independent producers.
(2) Critics describe it as unwieldy, unfocused and unlikely to achieve its aims – a sledgehammer to crack a nut.
(3) The shakeup comes after criticism that Ofsted’s current approach is debilitating for school leaders, while its unwieldy organisation has left it unable to spot damaging changes within schools involved in the Trojan horse affair, some of which Ofsted had judged to be outstanding.
(4) Its current crisis stems in part from it being too big, too unwieldy to control.
(5) Characterised by large, unwieldy, centralised organisations, the anti-war movement became complacent, overly reliant on rallies and petitions.
(6) The ultrasonic urologic probe is an unwieldy instrument for cardiac surgery, and we suggest the manufacture of a new probe for clinical use in our specialty.
(7) The results bring an end to an unwieldy four-year "grand coalition" between the CDU and the Social Democrats (SPD).
(8) Other milestones have already been reached: a draft text is in preparation , much slimmed down from previous unwieldy versions, and evidence has been produced that current pledges from rich countries to provide financial assistance to the developing world will reach required levels by 2020.
(9) Although that campaign had succeeded, its unwieldy federal model of multi-party cooperation was judged dysfunctional.
(10) Jeronimo said it would need to be priced close to its rivals, but the Apple brand would draw customers who either could not afford the larger iPad or considered it too unwieldy.
(11) The enormity of the denominator in contraceptive steroid usage is so unwieldy that mechanisms to measure accurately the difference in an extremely small numerator are still plaguing the epidemiologist, who at best can supply only estimates.
(12) Echoing fears among many MPs that Bank of England governor Sir Mervyn King and his successors will control an unwieldy empire of regulatory committees that could challenge the Treasury's democratic mandate, Barker criticised government plans to create a financial policy committee (FPC) alongside the Bank's monetary policy committee (MPC), which sets interest rates.
(13) Last Thursday the CLP shut down an inquiry into the past two decades of political donations in the NT, as well as the nature of the Foundation 51 organisation – alleged to be a CLP slush fund – claiming it would be “unwieldy” and overly costly for the territory.
(14) Like many lymphocyte-monocyte products, this activity has been difficult to purify because of its low abundance in activated leukocyte cultures and the unwieldy bioassay required to detect biological activity.
(15) Sometimes he overcomplicates his work, to a point where the result is unwieldy.
(16) At the level of first contact, a primary health care centre, information management is an unwieldy task, therefore health information systems are reported to be inadequate and weak.
(17) The relevance of continuing education to clinical staff will be discussed in relation to the change in the content of nursing theory--from the unwieldy 'certainty-based' medical model, to a more flexible, thus perhaps 'uncertainty-based' medical model.
(18) While at the outset it can seem unwieldy, general consensus seems to be that it can work more effectively in challenging times.
(19) As Peter Kendall, then president of the National Farmers Union, put it to me at the time: while Clarke’s heart was clearly in the right place, “the company is an unwieldy tanker to turn around.
(20) The business minister Nick Boles said: “These changes will also simplify the law for businesses so they can spend less time worrying about unclear and unwieldy regulations.” Richard Lloyd, executive director of consumer group Which?, said: “Consumer law was crying out to be brought up to date to cope with the requirements and demands of today’s shoppers.