(n.) One of the higher alcohols of the paraffine series obtained from spermaceti as a white crystalline solid. It is so called because it occurs in the ethereal salt of lauric acid.
(a.) Deadly; mortal; fatal.
Example Sentences:
(1) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(2) In more than 70 per cent of these, brain injury is the decisive lethal factor.
(3) One rat strain (TAS) is susceptible to the anticoagulant and lethal effects of warfarin and the other two strains are homozygous for warfarin resistance genes from either wild Welsh (HW) or Scottish (HS) rats.
(4) The results are consistent with our previous suggestion that lethality for virulent SFV infection results from a lethal threshold of damage to neurons in the CNS and that attenuating mutations may reduce neuronal damage below this threshold level.
(5) Osteogenesis imperfecta is the common term for a heterogeneous group of heritable disorders of connective tissue with lethal and nonlethal forms.
(6) It was recently demonstrated that MRL-lpr lymphoid cells transferred into lethally irradiated MRL- +mice unexpectedly failed to induce the early onset of lupus syndrome and massive lymphadenopathy of the donor, instead they caused a severe wasting syndrome resembling graft-vs-host (GvH) disease.
(7) The marine vibrio alone is a powerful stimulus to mucus secretion but lethal for the host.
(8) In-vivo data are limited primarily to dominant lethal studies in rats and some in-vivo alkaline elution results.
(9) None of these MAbs showed any virus-neutralizing activity in vitro; however, mice passively immunized with the purified MAbs were protected from lethal infection by the JHM strain of mouse hepatitis virus.
(10) A variation of a procedure for localized mutagenesis (Hong and Ames, 1971) was employed to generate conditional lethal mutants in phosphatidylserine decarboxylase.
(11) A highly significant correlation was observed between neutralization of indirect hemolysis and neutralization of lethal activity.
(12) A retrospective study was conducted into 136 patients who had received surgical treatment for perforated gastroduodenal ulcers, with the view to establishing postoperative lethality and morbidity (comparing simple suturing with definitive ulcer surgery).
(13) These measures excluded unfavourable lethal outcomes even in cases complicated by Gayet-Wernicke encephalopathy.
(14) Frequency and localization of spontaneous and induced by high temperature (37 degrees C) recessive lethal mutations in X-chromosome of females belonging to the 1(1) ts 403 strain defective in synthesis of heat-shock proteins (HSP) were studied.
(15) As a consequence of deformation from spherical-to-cylindrical shape in the microvasculature, demands for increased surface membrane area leads to increases in surface membrane tension above critical levels for rupture, and the cancer cells are rapidly and lethally damaged.
(16) In almost 80% of sudden cardiac deaths in ACMP foci of acute myocardial ischemia are found, that can lead to ventricular fibrillation with lethal outcome.
(17) Analysis of the literature data on the use of various therapeutic approaches to the treatment of febrile schizophrenia has shown that so far psychiatry does not possess such methods of treatment which could allow the complete prevention of lethal outcomes in this disease.
(18) Our previous results have shown that SC injection of DHEA resulted in upregulation of the specific host immune response resulting in protection against a lethal infection.
(19) Recently, this laboratory has demonstrated an enhanced susceptibility toward the development of ischemia-related lethal ventricular arrhythmias in the presence of therapeutic serum concentrations of digoxin in conscious dogs after myocardial infarction.
(20) The results are discussed in terms of possible conjugation-associated changes that, at high Hfr to F(-) ratios, lead to lethal zygosis.
Paraffine
Definition:
(n.) A white waxy substance, resembling spermaceti, tasteless and odorless, and obtained from coal tar, wood tar, petroleum, etc., by distillation. It is used as an illuminant and lubricant. It is very inert, not being acted upon by most of the strong chemical reagents. It was formerly regarded as a definite compound, but is now known to be a complex mixture of several higher hydrocarbons of the methane or marsh-gas series; hence, by extension, any substance, whether solid, liquid, or gaseous, of the same chemical series; thus coal gas and kerosene consist largely of paraffins.
Example Sentences:
(1) Flow cytometric DNA analysis was performed on both fresh and on paraffin embedded samples obtained by gastroscopic biopsies in 5 patients with histologically normal gastric mucosa (20 specimens) and by radical gastrectomies in 9 cases of human gastric cancer (36 specimens).
(2) Biotin-avidin immunoperoxidase analysis for hCG was performed on all paraffin blocks containing carcinoma-in-situ, grade I, grade II, and grade III transitional cell carcinoma.
(3) Using an antibody to the nerve growth factor receptor (NGFR), we examined dendritic reticulum cells (DRCs) immunohistochemically in 62 formalin-fixed, paraffin-embedded lymph nodes from patients with reactive follicular hyperplasia or with various types of lymphoma.
(4) In contrast, in paraffin as well as in frozen sections of chick oviduct, fixed by immersion or in vapor, PR was exclusively nuclear, including in the absence of progesterone, and the intensity of immunostaining was not modified by progesterone treatment.
(5) Using a silver staining technique (AgNOR technique), we have investigated the nucleolar organizer-associated proteins (NORs) in formalin-fixed paraffin embedded conjunctival specimens of 15 intraepithelial squamous carcinomas, 10 hyperplastic-dysplastic samples and 10 control epithelial fragments; the mean number of intranuclear black dots was determined for each case.
(6) This study shows that the sensitivity and specificity of in situ hybridisation for the detection of EBV genomes in AIDS related lymphomas approaches that of Southern blotting, even when using routinely processed archival, paraffin wax embedded material.
(7) Formalin-fixed, paraffin-embedded tissue was processed by the avidin-biotin complex method.
(8) This is the first report of anti-CD34 staining of acute leukemia in paraffin-embedded sections.
(9) The routine study of bone marrow trephine biopsies involves fixation, decalcification, paraffin-embedment, sectioning and staining.
(10) Paraffin sections (8 microns) containing the medial habenular nucleus were stained with cresyl violet and both left and right medial habenular nuclei were measured by planimetry.
(11) Formalin-fixed, paraffin-embedded tissue samples of canine amelanotic melanomas and normal canine tissues were studied immunohistochemically for the presence of S100 protein.
(12) Histological sections of formalin-fixed, paraffin-embedded tissue comprising 60 surgical specimens of human lung carcinoma were Feulgen stained.
(13) Urothelial cells were pepsin-extracted from paraffin-embedded specimens taken from human nontumorous bladder mucosa, dysplasia, and carcinoma in situ.
(14) Pieces of spleen of both groups were fixed in formalin and embedded in paraffin.
(15) Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER content.
(16) We conclude that there appears to be no benefit from exceeding a concentration of 5% crude coal tar in yellow soft paraffin in the treatment of patients with psoriasis and that the plateau in the dose-response curve for the action of crude coal tar in psoriasis begins at a point between 1 and 5%.
(17) Mycobacterium avium-intracellulare (MAI) can utilize paraffin wax as the sole carbon source in basal media.
(18) Following biotinylation, it was used to detect mannose-specific binding sites in fixed cells of seven human leukemia or lymphoma lines and in fixed, paraffin-embedded sections of human breast cancer.
(19) The parotid saliva of the caries-rampant group showed a significantly higher level of anodemigrating proteins, predominantly isoamylases, and a significantly lower level of cathode-migrating proteins than that of the caries-resistant group in both paraffin-stimulated and sour lemon-stimulated salivary flows.
(20) Ten tissue sections from 10 examples of Bowen's disease were excised from paraffin blocks, rehydrated, and incubated in 90% formic acid at 45 degrees C for 18 h. The epidermis was gently removed with the aid of a dissecting microscope, and the remaining dermis with attached basal lamina was processed for scanning electron microscopy.