(n.) Extreme disgust; a feeling of aversion, nausea, abhorrence, or detestation.
Example Sentences:
(1) Those with no idea of what he looks like might struggle to identify this modest figure as one of the world's most exalted film-makers, or the red devil loathed by rightwing pundits from Michael Gove down.
(2) He also loathed war, and later opposed the Falklands, Gulf and Kosovo campaigns.
(3) Mutual loathing (if this is the opinion of trained soldiers, what must it be like among the population?)
(4) The Freedom Caucus, a group of Tea Party conservatives, have come to loathe Boehner for working too closely with House Democrats and the White House to pass bills – including last week’s continuing resolution to fund the government – despite their inclusion of provisions hated by the right, such as funding for Planned Parenthood and Obamacare.
(5) The Gogglebox people are all nice(ish) and funny(ish), qualities vital to keep at bay total self-loathing that we are gathered as a family, watching on telly other people watching telly.
(6) for which Taylor won her second Oscar, playing the bitter, 52-year-old, vulgar wife of a self-loathing professor (Burton).
(7) Bridget's combination of self-loathing, enthusiasm and hope against the odds struck a chord.
(8) We loathe each other," is the latest from his nemesis on that.)
(9) It is now the official opposition, boosted by the star quality of the Tory leader Ruth Davidson and Scotland has given the once loathed party of Margaret Thatcher its biggest fillip since the 1950s.
(10) So, by that token, the public would have loathed PMQs and loved the civilised debate on Stafford hospital that followed.
(11) But anyone who has had to apply for sickness benefits may find that the name triggers – according to one MP – a sense of "fear and loathing".
(12) Detained by US immigration: 'In that moment I loathed America' | Mem Fox Read more After receiving notice that his Nexus card – part of a program designed to expedite border crossings for low-risk, pre-approved travellers – had been revoked, Ahmad decided to use his lunch break on Friday to pay a visit to the Nexus office in Michigan.
(13) The ministering of fear: dystopia and loathing at the Republican convention Read more Fortified versions of Soviet “ Zil lanes ” allowed leaders to shuttle safely between venues, behind high fences separating them from the rest of the street.
(14) If they did, they are smart,” he offered although, while the manager was loath to admit it, the suspended Cesc Fàbregas had still been missed.
(15) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.
(16) During his time as education secretary, Michael Gove was loathed by the majority of the education professionals.
(17) He has been derided in these pages, but that derision is surpassed by the venomous hatred of the Daily Mail , which loathes the Cameron government in any case and particularly despised Mitchell in his previous job.
(18) Truly, a titbit with such potential for female anxiety and self-loathing is like an iron filing to the media's magnet.
(19) Meanwhile, Tory backbenchers' cup of loathing for the Lib Dems overflows.
(20) Margaret Thatcher’s ideological spite towards a working class that she loathed for their solidarity had robbed huge swaths of the country of their sense of identity.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.