(1) Twelve families with Wiskott-Aldrich syndrome (WAS) were studied by linkage analysis using 10 polymorphic marker loci from the X-chromosome pericentromeric region.
(2) The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for comparison, in a panel of 103 cases of B- and T-cell non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs).
(3) The haplotype of the recombinant X chromosome of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1.
(4) Cell lines specific for class I or class II loci of the MHC produced interferon and colony-stimulating factors.
(5) Genetical analysis revealed that resistance to trimethoprim resulted from forward mutations at separate loci rather than back mutations of rad 6 or rad 18 alleles.
(6) However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility.
(7) Further methods for the typing of gene products of HLA-D or closely-linked loci are described.
(8) Here we report on the identification of four loci, pim-1, bmi-1, pal-1, and bla-1, which are occupied by proviruses in 35%, 35%, 28%, and 14% of the tumors, respectively.
(9) Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci.
(10) The polygenic control of diabetogenesis in NOD mice, in which a recessive gene linked to the major histocompatibility complex is but one of several controlling loci, suggests that similar polygenic interactions underlie this type of diabetes in humans.
(11) Radiation hybrid mapping is a somatic cell technique for ordering human loci along a chromosome and estimating the physical distance between adjacent loci.
(12) A total of 43 tra-3 revertants (one intragenic, 42 extragenic) have been isolated and analyzed, in the hope of identifying new sex-determination loci.
(13) This is Part I of a study whose purpose is two-fold, that is, to arrive at a classification of diseases under investigation according to their responsiveness to acupuncture therapy, and to discuss and identify the most effective loci for the diseases investigated.
(14) We studied bobbed loci at different magnification steps, analysing their behaviour through the reversion process and the way they carry out a second round of magnification.
(15) Karyotyping of the "wild-type" line and selected mutant clones showed that the loss of HLA specificities correlated with deletions which map the HLA-A and -B loci directly to the distal part of the 6p21.33 region and the class II genes to the region 6p21.33 (proximal) to 6p21.31 (distal) on the short arm of chromosome 6.
(16) The sum1 mutation affects expression of both a and alpha information at the HM loci.
(17) A total of 303 isolates of Bordetella bronchiseptica recovered from 11 host species were characterized by the electrophoretic mobilities of 15 metabolic enzymes, and 21 distinctive multilocus genotypes (electrophoretic types) were distinguished on the basis of allele profiles at the enzyme loci.
(18) Electrophysiological methods were used to determine changes in the neural representation of the binocular visual field at the paired midbrain optic tecta and in the tectal projection of pairs of corresponding retinal loci at various developmental points between these ages.
(19) To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders.
(20) Here we report evidence of at least four independently segregating loci in the mouse homologous to the M31 cDNA.
Lock
Definition:
(n.) A tuft of hair; a flock or small quantity of wool, hay, or other like substance; a tress or ringlet of hair.
(n.) Anything that fastens; specifically, a fastening, as for a door, a lid, a trunk, a drawer, and the like, in which a bolt is moved by a key so as to hold or to release the thing fastened.
(n.) A fastening together or interlacing; a closing of one thing upon another; a state of being fixed or immovable.
(n.) A place from which egress is prevented, as by a lock.
(n.) The barrier or works which confine the water of a stream or canal.
(n.) An inclosure in a canal with gates at each end, used in raising or lowering boats as they pass from one level to another; -- called also lift lock.
(n.) That part or apparatus of a firearm by which the charge is exploded; as, a matchlock, flintlock, percussion lock, etc.
(n.) A device for keeping a wheel from turning.
(n.) A grapple in wrestling.
(v. t.) To fasten with a lock, or as with a lock; to make fast; to prevent free movement of; as, to lock a door, a carriage wheel, a river, etc.
(v. t.) To prevent ingress or access to, or exit from, by fastening the lock or locks of; -- often with up; as, to lock or lock up, a house, jail, room, trunk. etc.
(v. t.) To fasten in or out, or to make secure by means of, or as with, locks; to confine, or to shut in or out -- often with up; as, to lock one's self in a room; to lock up the prisoners; to lock up one's silver; to lock intruders out of the house; to lock money into a vault; to lock a child in one's arms; to lock a secret in one's breast.
(v. t.) To link together; to clasp closely; as, to lock arms.
(v. t.) To furnish with locks; also, to raise or lower (a boat) in a lock.
(v. t.) To seize, as the sword arm of an antagonist, by turning the left arm around it, to disarm him.
(v. i.) To become fast, as by means of a lock or by interlacing; as, the door locks close.
Example Sentences:
(1) A bouncy function has now been incorporated into a knee of the semi-automatic knee lock design in a pilot laboratory trial involving six patients.
(2) The only other black woman I see in the building: washing dishes behind a door that was supposed to have been locked.
(3) In contrast, 1:1 phase locking characterized the electrical correlates of the duodenal activity front.
(4) When you hear the name Jesus, is the first image that comes to mind a dewy-eyed pretty boy with flowing locks?
(5) The commonly used line-to-line reaming technique was compared to an underreaming technique using both four-fifths and one-third porous-coated anatomic medullary locking (AML) implants.
(6) Andrew and his wife Amy belong to Generation Rent, an army of millions, all locked out of home ownership in Britain.
(7) While the Spielberg of popular myth is Mr Nice Guy, Lean was known as an obsessive, cantankerous tyrant who didn't much like actors and was only truly happy locked away in the editing suite.
(8) One top Republican official told the Guardian the party has for months been locked in secret talks with TV networks about how – or whether – it will fit all the candidates onstage for the primary debates.
(9) We develop an analogy between the steric hindrance among receptors detecting randomly placed haptens and the temporary locking of a Geiger counter that has detected a radioactive decay.
(10) On Wednesday, managing director Mike Devereux also flagged that the company's future in the country was not certain if government funding was not locked in over a long period.
(11) The violence led to the temporary suspension of the council's monthly meeting with some staff at one stage locked in rooms to ensure their safety.
(12) There have been reports of difficulties with the seating and locking of the vaporisers which can cause a leak and failure of vapour delivery.
(13) Such mutations lead to a major reduction in the rate of GTP hydrolysis by the complex of ras p21 and the GTPase activating protein (GAP) and lock the protein in a growth-promoting state.
(14) He was a fixture at Trump rallies, where he met chants of “Lock her up” against Hillary Clinton with a smile.
(15) No doubt New Labour ministers would regard such moves as protectionism, locked as they are in a discredited free-market mindset.
(16) So-called "structured" savings accounts promoted heavily by banks and building societies promise savers extra interest if they lock their money away for at least five years.
(17) Palmer sought to clarify his statements on Tuesday, and said they were aimed at the company he is currently locked in a dispute with, and not the broader Chinese population.
(18) Foveal exposures that did not produce an immediately visible lesion did not produce measurable changes in VEP response lock-in time.
(19) Scream Queens is the kind of show where you discover a secret locked room in the basement in one scene and then we find out exactly what is in the room three scenes later.
(20) In a group of the MS-DB units with stable background theta bursts the typical response consisting of entrainment of the phase-locked theta cycles was changed neither by physostigmine, nor by cholinergic-blocking drugs (scopolamine and atropine).