(n.) Any disease of the human body; a distemper, disorder, or indisposition, proceeding from impaired, defective, or morbid organic functions; especially, a lingering or deep-seated disorder.
(n.) A moral or mental defect or disorder.
Example Sentences:
(1) It shares some characteristics with the maladie dermatophytique of Hadida and Schousboe.
(2) This treatment was given to 11 patients with Huntington's chorea (ChH), 4 with faciolingual dyskinesis (DFL), 3 with torticollis spasmodicus (TS), 3 with maladie des tics (MT) and 8 with dyskinesia following treatment with L-dopa (MP).
(3) The cries were the pain cries of 2 normal newborns, 1 infant with maladie du cri du chat, 1 with Down syndrome, 1 asphyxiated infant with brain damage, and one asphyxiated infant without brain damage.
(4) We are not claiming that this procedure is a cure for CHD; rather, it is a procedure that dramatically slows down the progress of this malady and allows the dog to lead a more normal lifestyle and avoids euthanasia.
(5) These and other maladies and temptations are a danger for every Christian and for any administrative organisation … and can strike at both the individual and the corporate level,” he said.
(6) It is a microcosm of the region’s maladies and the trauma they have wrought on civilian lives – there are people here who have been wounded in sectarian bloodletting, shelling, airstrikes, occupation and crackdowns by dictators.
(7) Acalculous cholecystitis is an unusual but serious variant of a common disorder in which treatable gallbladder disease may masquerade as a less treatable liver malady.
(8) Although high resolution CT is preferable for study of common maladies of the middle ear and optic capsule, MRI is currently the study of choice for evaluation of the internal auditory canal, cerebellopontine angle, and brainstem.
(9) 93% of the subjects suffered from diabetes mellitus as the basal malady, which was comparable to that in Western studies.
(10) In children with known associated severe medical maladies, diagnostic barium enema can serve to reaffirm the diagnosis prior to the hazardous operative intervention.
(11) No mention of how losing weight (and avoiding maladies) through such surgery could save the NHS millions and therefore be classed as relatively cost-effective.
(12) When humans encounter marine creatures a variety of maladies may occur, ranging from dermatitis to life-threatening trauma, allergy, envenomations, or intoxications.
(13) A very high percentage of farm flock poultry maladies can be diagnosed by gross lesions plus a few simple laboratory procedures, such as direct microscopy, Gram's stain, fecal flotation, and aerobic bacteriology.
(14) Nostalgia was the soldiers’ malady – a state of mind that made life in the here and now a debilitating process of yearning for that which had been lost: rose-tinted peace, happiness, loved ones.
(15) Using a double-blind crossover technique in patients suffering from maladies associated with gastrointestinal spasm, sustained-release 40 mg dicyclomine hydrochloride tablets (Merbentyl Dospan) have been compared with 20 mg plain dicyclomine hydrochloride tablets (Merbentyl).
(16) In the majority of cases the grafts were penetrating (105 out of 118 cases), and the overall analysis of the results is dependent on the following factors: -- Grafts performed as primary procedures in one eye or both eyes: if they develop maladie due greffon, it is usually the 'endothelial' form which appears between the first and third month; the prognosis is good (53-66 p. 100 cure with steroid therapy).
(17) This malady accounts for 20 to 30 per cent of all congenital cardiac defects and is representative of a cardiac lesion that increases pulmonary blood flow.
(18) Spirochetes were not isolated in Danbury or New Hartford, areas where this malady is rare.
(19) Nowhere are the symptoms of this malady more visible than in medicine.
(20) » Une résidente du village, Bella Kabatesi, 18 ans, dont les parents sont morts suite à une maladie lorsqu’elle avait quatre ans, a utilisé l’énergie solaire pour alimenter une veilleuse en mémoire du fondateur du village, désormais décédé.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.