(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Negligence
Definition:
(n.) The quality or state of being negligent; lack of due diligence or care; omission of duty; habitual neglect; heedlessness.
(n.) An act or instance of negligence or carelessness.
(n.) The omission of the care usual under the circumstances, being convertible with the Roman culpa. A specialist is bound to higher skill and diligence in his specialty than one who is not a specialist, and liability for negligence varies acordingly.
Example Sentences:
(1) Since all human cadaveric tissue is fixed whilst on the skeleton, we may assume that shrinkage of the muscles in such specimens is negligible.
(2) In group C there was a negligible increase of LVSWI despite a marked rise in PCWP.
(3) From this, it was suggested that a negligible amount of oestradiol was released from these compounds and that the oestradiol moiety was useful as a carrier for the nitrogen mustard moiety.
(4) However, the phosphorylation of a 73 kDa double band, which is negligible in the absence of added NaC1, is stimulated by this salt.
(5) Although T cells exposed to antigen in B-depleted LN of mu sm and irradiated mice gave negligible T proliferative responses in vitro, low but significant levels of primed T helper function were detected in a sensitive T helper assay in vivo.
(6) Factors of negligible importance prognostically were: complete sterilization at mammary and axillary level after radiotherapy, persistence of florid cancer tissue at mammary level and histiocytosis of the axillary lymph nodes.
(7) In addition, the trends in the three sets of data for the catalytic subunit indicate that ionic bonds are involved in binding PALA to the active site, and that non-productive binding by L-Asp is negligible under these experimental conditions.
(8) We feel that the above technique is simple and definitive with negligible complications.
(9) Activity peaked during the period corresponding to evening twilight and was negligible during the morning twilight period; in contrast, death feigning peaked during the morning twilight period.
(10) The adverse effects were negligible--one patient had light urticarial rash and pruritus.
(11) In contrast, corticosterone, testosterone, progesterone and oestradiol showed negligible ability to displace [3H]1 alpha,25-(OH)2D3 from its receptor.
(12) Despite its negligible amount, the DIssE RNA in virions appears to serve as the template for the synthesis of DIssE RNA in infected cells.
(13) Facial pain is a very constant phenomenon which does not- or only to a negligible degree--change over an agelong course.
(14) An abrupt decrease of the liver glycogen was found as well as a negligible rise of the blood sugar.
(15) In conclusion, respiratory morbidity is not negligible.
(16) The influence of sample preparation for electrophoresis was found to be negligible.
(17) "This age group feeds Radio 4's core audience and it would in my judgment be negligent not to [look at this]," Liddiment added.
(18) As far as the cardiovascular systems of the fetus and neonate are concerned the effects in the dosage used are negligible.
(19) Desaturation by 4 M MgCl2 indicated that the amount of endogenously bound hormone was negligible in our membrane preparations.
(20) With monoclonal antibody AA1, immunostaining was entirely specific for mast cell granules, and there was negligible background staining in a range of tissues including lung, tonsil, colon, gastric mucosa, skin, and pituitary.