(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Rancor
Definition:
(n.) The deepest malignity or spite; deep-seated enmity or malice; inveterate hatred.
Example Sentences:
(1) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(2) The developments come at a time of deep tension in Bangladesh , a nation struggling to overcome extreme poverty and rancorous politics.
(3) No one else need bother to paint them as a ramshackle and rancorous rabble marooned in the past and without a plausible account of the future.
(4) Arguments about this case, and the broader debate about the best way to tackle exploitative treatment of women in the sex industry, are unexpectedly rancorous.
(5) Trump approves of working with autocrats, at least, and would probably make fast friends with the galaxy’s less reputable leaders – especially those who share his interests, eg crimelord Jabba the Hutt, who lives in an ostentatious palace , loves parties , demeans women and feeds a literal Rancor .
(6) A sense of victimhood festers among even relatively advantaged white men, as the rancorously popular candidacy of Donald Trump confirms.
(7) This peaceful university town is 7,000 miles from the violence of the Middle East, but a proposal to become sister cities with a Palestinian community has stirred such rancor that the city council is trying to negotiate a truce among its own residents.
(8) While the contest has at times been rancorous, there is now a degree of bonhomie among the contenders – an esprit de corps that arises from having shared stages, green rooms and cars non-stop for nearly four months.
(9) Under Pinter's direction, Bates brilliantly brought out Butley's blend of rancorous wit and emotional immaturity; and it was to be the start of a long and fruitful assocation with Gray that included the lead roles in Otherwise Engaged (1975), for which Bates won an Evening Standard Best Actor award, Stage Struck (1979) and Melon (1987).
(10) That we demand a contest as satisfyingly unwholesome and rancorous as Cain and Abel, not something as nauseatingly wholesome and harmonious as Abel and Cole?
(11) Even in the most partisan and rancorous of times in Washington, there was enough respect for the two-party system and voters to avoid such an arrogant and autocratic move.
(12) Negotiations between the two sides have gone nowhere for five months and have become particularly rancorous in the past month as bailout and debt repayment deadlines came and went, with Athens missing a €1.5bn repayment to the IMF.
(13) Keegan haunts Ashley Mike Ashley, the Newcastle United owner, looks like he has learned the lessons of Kevin Keegan's rancorous 13-month battle for compensation after he was constructively dismissed as Newcastle manager in September 2008.
(14) That spirit of forgiveness is what we need more and more in this rancorous modern world.” The opposition leader, Bill Shorten, said the fresh calls for changes to the Racial Discrimination Act were a “ distasteful” attempt to use the French attack “to make domestic political points in Australia”.
(15) With Washington gripped by a growing sense that it may be too late to avert a crisis, the president has said he will give the increasingly rancorous negotiations until the end of next week to reach agreement on the terms for raising the US's $14.3 trillion (£8.9tn) debt ceiling.
(16) Photograph: Reuters The debate about restoring affordability to our cities is often rancorous and out of date.
(17) The legislation had an agonisingly tortuous passage through a rancorous and partisan Congress, but eventually it made it onto the statute book.
(18) John Gielgud highlighted Hamlet’s lyrical introspection, Laurence Olivier his athletic virility, Nicol Williamson his rancorous disgust, Mark Rylance his tormented isolation, David Tennant his mercurial humour.
(19) Thus, the usual forms of working time organization, with their arbitrary divisions, the monotony, repetitiveness and other restricting factors (stress), not only do not contribute to self-realization, but create rancor, boredom and drama.
(20) Barrett offers conciliation after a year and a half of unprecedented partisan rancor and disruptive political turmoil.