(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Rancour
Definition:
Example Sentences:
(1) Trump’s nomination has been described as a hostile takeover and there was hostility aplenty: a festival of bigotry, rancour and racially charged hatred.
(2) This sporting occasion did begin in remembrance of one of the most remarkable campaigns for justice, against a scandalous police cover-up, but it ended largely in rancour, and complaints about a referee, Mark Halsey.
(3) "What I would say from last night is there's no bad blood, there's no rancour, no bitterness."
(4) As the meeting degenerated into rancour, Greek banks stood on the brink of collapse after a flood of cash withdrawals on Thursday, raising the prospect of capital controls and temporary bank closures.
(5) The next round of intermediate negotiations, due to start in Bonn on 31 May , look set to take place in a poisonous atmosphere of bitterness and rancour.
(6) It comes amid rising rancour between rich and poor countries.
(7) It's necessary to outline the succession of injustices that Watson has suffered, the abominable luck and ongoing battles, to begin to appreciate his near total absence of rancour.
(8) Meanwhile, Scottish Labour is eating itself, the former leader departing amid rancour .
(9) After much online rancour, Pelevina agreed she would not stand in the elections, but wrote on Facebook that Yashin was a “simple liar, petty and vengeful, and simply an indecent person”.
(10) She says this entirely equably, without boast or rancour.
(11) Republican rancour over the budget deal boiled over again on Thursday, after Senator John McCain attacked a last-minute amendment to spend $2.8bn on infrastructure work on the Ohio river, which connects the political backyards of party leaders in the Senate and the House.
(12) After a year in office, Rouhani has evidently put an end to Ahmadinejad’s years of rancour.
(13) Less than four months later, amid rancour, rifts and reams of gleeful commentary in the mainstream Italian media, the euphoria of that stunning breakthrough appears largely to have evaporated.
(14) is as charming a slab of rancour as one could wish for, simultaneously puffed-up with righteous anger and utterly crushed by disappointment.
(15) Chelsea had done nothing wrong, but the rancour was inevitable.
(16) The talks on Greece have left a legacy of rancour not only between Greece and the union but also between different groupings within the EU, straining the Franco-German relationship in particular.
(17) Chalmers, the moderator of the General Assembly, said he had "repelled by the name-calling and rancour we have seen in recent weeks.
(18) It's a moment without rancour, without bitterness: a great sigh of relief at the inevitable acknowledgement of the obvious… it's time to go our separate ways.
(19) The rancour that has run through the summit between developed and developing nations broke out again when the Africa group of countries and others accused the UN chair of the conference of trying to "kill" the Kyoto protocol.
(20) In a domestic debate that mirrors the rancour and resentments that have broken out across the EU as leaders bicker endlessly over who should pay to rescue the euro, richer German states now complain about constantly having to help out poorer states via the national federal subsidies system.