(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Vicious
Definition:
(a.) Characterized by vice or defects; defective; faulty; imperfect.
(a.) Addicted to vice; corrupt in principles or conduct; depraved; wicked; as, vicious children; vicious examples; vicious conduct.
(a.) Not correct or pure; corrupt; as, vicious language; vicious idioms.
(a.) Not well tamed or broken; given to bad tricks; unruly; refractory; as, a vicious horse.
(a.) Bitter; spiteful; malignant.
Example Sentences:
(1) Los Angeles were relentless in their vicious pursuit of a game-tying goal on Wednesday, bidding to send Game 4 into overtime.
(2) But when in mid-October two of the artists received death threats, the menaces were widely reported and rekindled debate, prompting vicious, anti-Muslim comments on Danish talk shows.
(3) When he attacked New York, his vicious crusade was as much against skyscrapers as it was against western values and the US.
(4) A vicious feud playing out within Uzbekistan's ruling family took a new twist on Monday , when prosecutors announced that the clan's most flamboyant member faces charges of involvement in mafia-style corruption.
(5) This was evident just this week when, as an example, a young woman in San Francisco was viciously killed by a five-time deported Mexican with a long criminal record, who was forced back into the United States because they didn’t want him in Mexico.
(6) Each of these reactions can increase the perception of chest pain, contributing to a vicious cycle that exacerbates both the chest pain and the anxiety.
(7) This vicious circle should be broken rather by finding optimal conditions than by a middle course determined by experimental requirements, economical frames and general notions about what may be good for the animal.
(8) In spite of the relatively large sample and the given number of variables the problem of the vicious circle might occur.
(9) Recent data are cited for the proposition that these changes constitute a closed pathogenetic concatenation creating a vicious circle.
(10) When there is upheaval within China’s own borders – riots, protests, vicious political power struggles – hardly a sniff of it will be found in the pages of the country’s heavily-controlled press.
(11) According to the International Crisis Group , tensions within and between the two major political parties, competing claims to the presidency between northern and Niger Delta politicians and along religious lines, along with inadequate preparations by the electoral commission and apparent bias by security agencies, suggest the country is heading toward a volatile and vicious electoral contest.
(12) A vicious circle with the increased resistance as the key factor can be identified.
(13) This vicious cycle could be interrupted by segmental epidural anesthesia with procaine as well as by blockade of sympathoexcitation at the central nervous level with clonidine in anesthetized dogs.
(14) This is in stark comparison to the gruesome, vicious suffering that he inflicted on his two victims – and the lifetime of suffering he has caused their family.” Wood was executed for shooting to death Debra Dietz, his former girlfriend, and her father, Eugene Dietz, in Tucson in 1989.
(15) Spicer, who so viciously attacked the press on Saturday, had to hurriedly walk back the comments of his boss when Trump, during an interview with the Washington Post before the inauguration, promised “insurance for everybody”.
(16) Using mathematical models of the population dynamics of T helper cells, HIV and other pathogens we address three facets of the interactions between HIV and other pathogens: enhanced HIV replication due to immune stimulation by other pathogens; modified immune control of other pathogens due to immunosuppression by HIV; and the vicious circle formed by positive feedback between these two effects.
(17) Since the initially peaceful demonstrations against his regime began more than three years ago, he has proved himself, by turns, foolish, craven and vicious.
(18) He said US prisons were tough and safe enough to handle the most vicious al-Qaida terrorist suspects now held at Guantánamo.
(19) When Cruise announced last October that he was suing Bauer, his lawyer, Bert Fields, described the claim that the actor had deserted his daughter as a “vicious lie”.
(20) Meanwhile, people in poor countries are already battling its vicious storms.