(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Wickedness
Definition:
(n.) The quality or state of being wicked; departure from the rules of the divine or the moral law; evil disposition or practices; immorality; depravity; sinfulness.
(n.) A wicked thing or act; crime; sin; iniquity.
Example Sentences:
(1) But just as Oliver Stone has managed to make a boring sequel to Wall Street, despite the real Wall Street's enthralling and nigh-on-cinematic recent wickedness (the inner Freudian torment of boring Shia LaBoeuf's boring character is apparently more interesting to Stone – once the great purveyor of conspiracy theories – than the near-collapse of capitalism), so the makers of the upcoming films about Facebook have missed an obvious trick with their movies.
(2) Tony Abbott has recently delivered an explicit warning that the Daesh death cult is “coming for us”, however, Turnbull argued it was important not to get sucked into the Isis strategy “and ourselves become amplifiers of their wickedness and significance”.
(3) It is towards an anti-government fervour that recalls the militia movement of the 1990s, convinced that every Washington move – even a plan to expand healthcare – is motivated by wickedness and constitutes a step towards tyranny.
(4) Less welcome was Professor Griff's 1989 interview with the Washington Times where he condemned Jews as responsible for 'the majority of the wickedness that goes on across the globe'.
(5) Facebook Twitter Pinterest Video: Volkswagen chief executive Martin Winterkorn resigns, taking responsibility for the German carmaker’s rigging of US emissions tests Yet it would be simplistic to blame the wickedness of the industry and to suppose that the consumers involved were entirely innocent idealists, cruelly misled by unscrupulous marketeers.
(6) I know we are supposed to present them as extreme wickedness but they don’t appear like that to lots of Labour voters who thought this was mainstream Labour policy.
(7) There is a certain perverse charm to what appears to be Sepp’s final mission: exposing the weaknesses and wickedness of everyone who has profited from his regime down the decades.
(8) Maybe that’s because Laurie’s Roper has been enter taining us for so long with his cool, his wit, his urbanity and his sheer wickedness that we don’t want to let him go.
(9) They lament western wickedness with the reliability of professional mourners.
(10) Before tragedy strikes, we must all take the initiative and talk to these families, listen to their problems but, ultimately, we must take proactive steps to help them before "hate" and "wickedness" take a hold.
(11) We now know the banks' tricks involved not just dubious wizardry but a measure of wickedness too.
(12) Alice Morgan – said patricidal psychopath, played with delicious wickedness by Ruth Wilson – is one of TV's most unusual sidekicks.
(13) When I asked my friend the professor of gender studies about all this stuff some time ago (I know this sounds like the overture to a joke, but it isn't), I was semi-secretly hoping for a jeremiad on the wickedness of princess-mania, and tips on how she'd saved her daughters from it.Actually, she said, one of hers had that obsession too, for a bit – but that other obsessions came along to supplant them.
(14) This warning about the lure of wickedness reveals how Prince’s vision of the battle between good and evil was much darker than Burton’s take.
(15) When the full extent of his wickedness was revealed, we put him in a box marked "monster".
(16) Just as some were putting the wickedness of Savile and his ilk in a box marked “long ago”, Rochdale broke and the abuse of children in care was revealed.
(17) Under the amendment the same buildings, the same canteen, the same umbrella stands, the same courses, the same bitching about Orbán and his wickedness can continue, and students can get a qualification recognised in Europe .
(18) Stories such as the prime minister’s surprisingly resilient support for the charity, the lobbying of a Conservative party co-treasurer – James Lupton – and the embedding of two civil servants to help restructure the organisation somehow became examples of the wickedness that had taken root in the charity.
(19) What many people seem to want is to be confirmed in their view that all of this is down to the personal wickedness of a single individual; arrest Blair, clap him in irons at The Hague, and everything will return to a state of primal, unsullied innocence.
(20) The virtue of Israel and the wickedness of her enemies are recurring themes in his work."