(a.) Designated or distinguished by, or as by, a mark; hence; noticeable; conspicuous; as, a marked card; a marked coin; a marked instance.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(3) Following in vitro C activation in NHS by delta IgG, the 40 KD C4d component increased markedly.
(4) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
(5) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(6) Increased dietary protein intake led to increased MDA per nephron, increased urinary excretion of MDA, and increased MDA per milligram protein in subtotally nephrectomized animals, and markedly increased the glutathione redox ratio.
(7) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(8) Surprisingly, the clonal elimination of V beta 6+ cells is preceded by marked expansion of these cells.
(9) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(10) of PLA2 caused marked degranulation of mast cells in the rat mesentery which was facilitated by addition of calcium ion (10 mM) but antagonized by pretreating with three antiinflammatory agents.
(11) report the complications registered, in particular: lead's displacing 6.2%, run away 0.7%, marked hyperthermya 0.0%, haemorrage 0.4%, wound dehiscence 0.3%, asectic necrosis by decubitus 5%, septic necrosis 0.3%, perforation of the heart 0.2%, pulmonary embolism 0.1%.
(12) Marked enhancement of IFN-gamma production by T cells was seen in the presence of as little as 0.3% thymic DC.
(13) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(14) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(15) A marked overlap of input from the two eyes is an unusual feature for a diprotodont marsupial and has previously been seen only in the feathertail glider.
(16) The erythrocyte sedimentation rate is almost always markedly elevated.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(20) The introduction of intravenous, high-dose thrombolytic therapy during a brief period has markedly reduced mortality of patients with acute myocardial infarction.
Notorious
Definition:
(a.) Generally known and talked of by the public; universally believed to be true; manifest to the world; evident; -- usually in an unfavorable sense; as, a notorious thief; a notorious crime or vice.
Example Sentences:
(1) There will be no statutory inquiry or independent review into the notorious clash between police and miners at Orgreave on 18 June 1984 , the home secretary, Amber Rudd, has announced.
(2) To become president of Afghanistan , Ashraf Ghani Ahmadzai changed his wardrobe and modified his name, gave up coffee, embraced a man he once denounced as a “known killer” and even toyed with anger management classes to tame a notorious temper.
(3) In his notorious 1835 Minute on Education , Lord Macaulay articulated the classic reason for teaching English, but only to a small minority of Indians: “We must do our best to form a class who may be interpreters between us and the millions whom we govern; a class of persons, Indians in blood and colour, but English in taste, in opinions, in morals and in intellect.” The language was taught to a few to serve as intermediaries between the rulers and the ruled.
(4) In June, a notorious elephant poacher led a gang of bandits in an attack on the Okapi wildlife reserve in DRC, killing seven people.
(5) Even as the Obama administration moves to deal with some of Guantánamo's most notorious captives, it faces tough challenges to closing the facility.
(6) The council offered him a tea urn | Frances Ryan Read more Government attempts to decrease the disproportionately high levels of unemployment among disabled people have had little impact, the report notes, while notorious “fit-for-work” tests were riven with flaws.
(7) The Colorado-based tycoon is notoriously secretive and at one point looked as if he was going to mount a rival bid for the US satellite TV company.
(8) It would also be likely to lend scope to ill-conceived prosecutions jeopardising ordinary free speech rights, such as the notorious Twitter Joke Trial .
(9) I will not be alone in watching closely to see what difference – if any – it makes to have a (highly competent) woman at the helm of an organisation which remains, with its notorious “canteen culture”, still a boys’ club in so many ways.
(10) Experts and activists have said the murder bore all the hallmarks of Egypt’s notorious secret service, but Egyptian officials have consistently put forward alternative theories, including that Regeni was killed by a criminal gang and that his death was an isolated incident.
(11) Many of the issues that arise in the Oxfordshire case also arose in some form in the other notorious child abuse cases of the modern era.
(12) It is bad enough that the minimum wage required by law is hardly generous, yet there we were again last week confronted with reports of delivery company Hermes exploiting workers , HM Revenue & Customs widening its investigation into the notorious wages shirker Sports Direct and a challenge to Uber’s employment practices.
(13) But defenders of Ihat recall the notorious case of Baha Mousa , an Iraqi who died in British detention, and note that the MoD has paid out £22m in compensation to victims of alleged abuse in Iraq.
(14) Although it is the world's biggest CO2 emitter and notorious for building the equivalent of a 400MW coal-fired power station every three days, it is also erecting 36 wind turbines a day and building a robust new electricity grid to send this power thousands of miles across the country from the deserts of the west to the cities of the east.
(15) ‘You help us and we’ll take care of you’: a windfall of abuse hits minorities in the Windy City – and Lee Harris Facebook Twitter Pinterest The notoriously abusive Chicago police officer Jon Burge (top) was released on Friday.
(16) Her most notorious performance came during the Falklands war of 1982 when she made little or no effort to disguise her distaste for American diplomatic support of Britain.
(17) In a 59-page report published on Friday, the force revealed that eight of its officers attended Savile's notorious "Friday Morning Club" to socialise with the former DJ at his home in Leeds, including four who attended regularly over a number of years.
(18) The epidemiological approach to occupational accidents and diseases adopted in Brazil is inadequate for many reasons, among them being: 1) the fact that only employers may notify work accidents, thus permitting notorious undernotification of these occupational hazards; 2) the available information does not permit a better understanding of the causal relationship between work accidents and diseases; 3) the official policy exists only for purposes of insurance compensation.
(19) It was one of the most notorious miscarriages of justice in British legal history.
(20) Estimates of panda numbers in the wild vary enormously due to the difficulty of collecting data about the notoriously shy animal, which lives in dense, high-altitude vegetation: the last survey required more than 35,000 volunteers.