(n.) An established principle or proposition; a condensed proposition of important practical truth; an axiom of practical wisdom; an adage; a proverb; an aphorism.
(n.) The longest note formerly used, equal to two longs, or four breves; a large.
Example Sentences:
(1) We maximize an objective function that includes both total production rate and product concentration.
(2) Further, the maximal increase in force of contraction was measured using papillary muscle strips from some of these patients.
(3) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(4) Maximal yields of lipid and aflatoxin were obtained with 30% glucose, whereas mold growth, expressed as dry weight, was maximal when the medium contained 10% glucose.
(5) Maximal aberration yields were observed for 2,4-diaminotoluene, 2,6-diaminotoluene and cytosine beta-D-arabinofuranoside from 17 to 21 h, eugenol from 15 to 21 h, cadmium sulfate from 15 to 24 h and 2-aminobiphenyl, from 17 to 24 h. For adriamycin at 1 microM, the % aberrant cells remained elevated throughout the period from 9 to 29 h, while small increases at 0.1 microM ADR were found only at 13 and at 25 h. For most chemicals the maximal aberration yield occurred at a different time for each concentration tested.
(6) Maximal covalent binding of [4,5-14C]ronidazole to DNA also required four-electron reduction, consistent with previous studies of the covalent binding of this agent to immobilized sulfhydryl groups [Kedderis et al.
(7) The Cao-dependent Na+ efflux was half-maximally activated by [Ca2+]o = 2.0 mM in LiSW and 7.2 mM in Tris-SW; at saturating [Ca2+]o, [Ca2+]i, and [Na+]i the maximal (calculated) Cao-dependent Na+ efflux was approximately 75 pmol#cm2.s.
(8) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(9) Combining maximally effective concentrations of each of these stimulating agents produces an additive increase in both the level of 32P incorporation into tyrosine hydroxylase and the degree of activation of the enzyme.
(10) Using serial section electron microscopic reconstructions as a reference, we have chosen as our standard procedure a method that maximizes both the preservation of the cytoskeleton and the proportion of cells staining, while minimizing the degree of nonspecific staining.
(11) Basal and maximally insulin-stimulated rates of 3-O-methylglucose transport in adipocytes from obese and obese NIDDM subjects were reduced to 50% of the values in cells from normal subjects (P less than 0.05).
(12) We assumed that the sensory messages received at a given level are transformed by a stochastic process, called Alopex, in a way which maximizes responses in central feature analyzers.
(13) Both gp175 and gp250 showed the greatest increase in fucosylation at 10(-5) M, which was also the dose at which RA induced laminin maximally, while the fucosylation of gp400 was greatest at 10(-8) M RA and declined at higher concentrations.
(14) However, those studies used partial maximal expiratory flow volume (PMEFV) curves to assess lung function.
(15) Hyperosmolar buffer slightly increased the sensitivity and maximal response to methacholine as well as the cholinergic twitch to electric field stimulation.
(16) Cytosolic-to-mitochondrial ratios from maximal initial rates after correction for mitochondrial breakage were increased above controls in diabetic hearts for nucleoside diphosphokinase and aspartate aminotransferase.
(17) The drug-picrate chromophores maximally absorb within the first minute of reaction (21 s for phenacemide, 45 s for cephalothin), after which the absorbances decrease.
(18) Glucagon can raise intracellular cyclic AMP about 30-fold; a half-maximal effect is obtained with 1.5 nM hormone.
(19) Keeping calcium concentration constant in the medium (0.36 microM), ornithine transport was maximal at 5.0 microM L-arginine and decreased at higher concentrations of arginine.
(20) Immediately prior to and at maximal workloads, carbon monoxide shifted into extravascular spaces and returned to the vascular space within five minutes after exercise stopped.
Principle
Definition:
(n.) Beginning; commencement.
(n.) A source, or origin; that from which anything proceeds; fundamental substance or energy; primordial substance; ultimate element, or cause.
(n.) An original faculty or endowment.
(n.) A fundamental truth; a comprehensive law or doctrine, from which others are derived, or on which others are founded; a general truth; an elementary proposition; a maxim; an axiom; a postulate.
(n.) A settled rule of action; a governing law of conduct; an opinion or belief which exercises a directing influence on the life and behavior; a rule (usually, a right rule) of conduct consistently directing one's actions; as, a person of no principle.
(n.) Any original inherent constituent which characterizes a substance, or gives it its essential properties, and which can usually be separated by analysis; -- applied especially to drugs, plant extracts, etc.
(v. t.) To equip with principles; to establish, or fix, in certain principles; to impress with any tenet, or rule of conduct, good or ill.
Example Sentences:
(1) Stress is laid on certain principles of diagnostic research in the event of extra-suprarenal pheochromocytomas.
(2) However, as the same task confronts the Lib Dems, do we not now have a priceless opportunity to bring the two parties together to undertake a fundamental rethink of the way social democratic principles and policies can be made relevant to modern society.
(3) To a supporter at the last election like me – someone who spoke alongside Nick Clegg at the curtain-raiser event for the party conference during the height of Labour's onslaught on civil liberties, and was assured privately by two leaders that the party was onside about civil liberties – this breach of trust and denial of principle is astonishing.
(4) The White House denied there had been an agreement, but said it was open in principle to such negotations.
(5) Using the MTT assay and analyzing the data using the median-effect principle, we showed that synergistic cytotoxic interactions exist between CDDP and VM in their liposomal form.
(6) The heretofore "permanently and totally disabled versus able-bodied" principle in welfare reforms is being abbandoned.
(7) The binding follows the principle of isotope dilution in the physiologic range of vitamin B12 present in human serum.
(8) The principle of the liquid and solid two-phase radioimmunoassay and its application to measuring the concentrations of triiodothyronine and thyroxine of human serum in a single sample at the same time are described in this paper.
(9) Spectrophotometric tests for the presence of a lysozyme-like principle in the serum also revealed similar trends with a significant loss of enzyme activity in 2,4,5-T-treated insects.
(10) All these strains produced an enterotoxic principle, antigenically related to cholera coli family of enterotoxins, as detected by latex agglutination and immuno-dot-blot tests.
(11) The basic principle of the resonant tool, its adaptation for surgery, the experimental results of its use in animals, and clinical experience are reported.
(12) It seems tragic, then, that so little of these principles transfer over to the container in which the work is done.
(13) This conception of the city as an expression of both regal power and social order, guided by cosmological principles and the pursuit of yin-yang equilibrium, was unlike anything in the western tradition.
(14) The general principles of bypass surgery as they affect the cerebral circulation are reviewed.
(15) The interest of this view resides in the resulting general principle of classification and interpretation of all forms of disease, giving rise to an "existenialistic pathology".
(16) Eight of the UK's biggest supermarkets have signed up to a set of principles following concerns that they were "failing to operate within the spirit of the law" over special offers and promotions for food and drink, the Office of Fair Trading has said.
(17) Although the general guiding principle of pharmacotherapy for anxiety disorders--the lowest effective dose for the shortest possible time--remains, this rule should not interfere with the judicious use of medications as long as the benefits justify it.
(18) In older stages, the cervical joints rotate according to geometric and lever arm principles.
(19) Spain’s constitutional court responded by unanimously ruling that the legislation had ignored and infringed the rules of the 1978 constitution , adding that the “principle of democracy cannot be considered to be separate from the unconditional primacy of the constitution”.
(20) The principles and practice of aneasthesia for patients having coronary bypass grafts are discussed.