(n.) One who mediates; especially, one who interposes between parties at variance for the purpose of reconciling them; hence, an intercessor.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Negotiate
Definition:
(v. i.) To transact business; to carry on trade.
(v. i.) To treat with another respecting purchase and sale or some business affair; to bargain or trade; as, to negotiate with a man for the purchase of goods or a farm.
(v. i.) To hold intercourse respecting a treaty, league, or convention; to treat with, respecting peace or commerce; to conduct communications or conferences.
(v. i.) To intrigue; to scheme.
(v. t.) To carry on negotiations concerning; to procure or arrange for by negotiation; as, to negotiate peace, or an exchange.
(v. t.) To transfer for a valuable consideration under rules of commercial law; to sell; to pass.
Example Sentences:
(1) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(2) "They wanted to pass it almost like a secret negotiation," she said.
(3) Parents believed they should try to normalize their child's experiences, that interactions with health care professionals required negotiation and assertiveness, and that they needed some support person(s) outside of the family.
(4) On Friday, a spokesperson for China’s foreign ministry appeared to confirm those fears, telling reporters that the joint declaration, a deal negotiated by London and Beijing guaranteeing Hong Kong’s way of life for 50 years, “was a historical document that no longer had any practical significance”.
(5) Britain had been negotiating with the Saudis over the purchase from British Aerospace of dozens of Hawk and Tornado fighter aircraft.
(6) The young European idealist who helped Leon Brittan, the British EU commissioner, to negotiate Chinese entry to the World Trade Organisation, also found his Spanish lawyer wife in Brussels.
(7) A Palestinian delegation was to hold truce talks on Sunday in Cairo with senior US and Egyptian officials, but Israel has said it sees no point in sending its negotiators to the meeting, citing what it says are Hamas breaches of previous agreed truces.
(8) But still we have to fight for health benefits, we have to jump through loops … Why doesn’t the NFL offer free healthcare for life, especially for those suffering from brain injury?” The commissioner, however, was quick to remind Davis that benefits are agreed as part of the collective bargaining process held between the league and the players’ union, and said that they had been extended during the most recent round of negotiations.
(9) One of the things Yang has said he wants to investigate is: "This state we're in ... a moment when we have to negotiate our past while inventing our present."
(10) To a large extent, the failure has been a consequence of a cold war-style deadlock – Russia and Iran on one side, and the west and most of the Arab world on the other – over the fate of Bashar al-Assad , a negotiating gap kept open by force in the shape of massive Russian and Iranian military support to keep the Syrian regime in place.
(11) In an interview with the Guardian, James Hansen, the world's pre-eminent climate scientist, said any agreement likely to emerge from the negotiations would be so deeply flawed that it would be better to start again from scratch.
(12) But if May rushes headlong into a panicked triggering of article 50 without a clear idea of what she wants out of negotiations, she will have left us at the mercy of 27 countries who have heard little but table-thumping and empty threats from ministers.
(13) Yesterday a new French president was elected – he was elected with a strong mandate which he can take into a strong position in negotiations.
(14) Paradigm relies heavily on social science research and analysis to help companies identify and address the specific barriers and unconscious biases that might be affecting their diversity efforts: things like anonymizing resumes so that employers can’t tell a candidate’s gender or ethnicity, or modifying a salary negotiation process that places women and minorities at a disadvantage.
(15) Pfizer kept up its efforts to get AstraZeneca to the negotiating table over its £63bn approach as it reported revenue well below Wall Street expectations, underscoring its interest in pursuing its UK rival to promote new business growth.
(16) Krell is also trying to lure Mothercare to the negotiating table.
(17) He said the group was in negotiation with media regulator Ofcom, which will look at them on a case-by-case basis.
(18) The fact that we’re tracking towards the hottest year on record should send chills through anyone who says they care about climate change – especially negotiators at the UN climate talks here in Lima,” said Samantha Smith, who heads WWF’s climate and energy initiative.
(19) "We believe there's a much fairer solution and are hopeful that today's demonstration will bring things back to the negotiating table."
(20) A new round of negotiations over the future of Iran's nuclear programme got under way on Wednesday, bringing together the Iranian foreign minister, Mohammad Javad Zarif, the EU foreign policy chief, Catherine Ashton, and top diplomats from the US, UK, France, Germany, Russia and China.