(n.) A miniature representation of a thing, with the several parts in due proportion; sometimes, a facsimile of the same size.
(n.) Something intended to serve, or that may serve, as a pattern of something to be made; a material representation or embodiment of an ideal; sometimes, a drawing; a plan; as, the clay model of a sculpture; the inventor's model of a machine.
(n.) Anything which serves, or may serve, as an example for imitation; as, a government formed on the model of the American constitution; a model of eloquence, virtue, or behavior.
(n.) That by which a thing is to be measured; standard.
(n.) Any copy, or resemblance, more or less exact.
(n.) A person who poses as a pattern to an artist.
(a.) Suitable to be taken as a model or pattern; as, a model house; a model husband.
(v. t.) To plan or form after a pattern; to form in model; to form a model or pattern for; to shape; to mold; to fashion; as, to model a house or a government; to model an edifice according to the plan delineated.
(v. i.) To make a copy or a pattern; to design or imitate forms; as, to model in wax.
Example Sentences:
(1) These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
(2) Therefore, these findings may extend the use of platelets as neuronal models.
(3) Models able to describe the events of cellular growth and division and the dynamics of cell populations are useful for the understanding of functional control mechanisms and for the theoretical support for automated analysis of flow cytometric data and of cell volume distributions.
(4) The testing of other models and their failure to describe the kinetic observations are discussed.
(5) The extreme quenching of the dioxetane chemiluminescence by both microsomes and phosphatidylcholine, as a model phospholipid, implies that despite the low quantum yield (approx.
(6) The results of our microscopic model confirm that the continuum hypothesis used in our previous macroscopic model is reasonable.
(7) To examine the central nervous system regulation of duodenal bicarbonate secretion, an animal model was developed that allowed cerebroventricular and intravenous injections as well as collection of duodenal perfusates in awake, freely moving rats.
(8) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(9) Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remodeling.
(10) Because of the dearth of epidemiological clues as to causation, studies with experimental animal models assume greater importance.
(11) The models are applied to estimate the demand for tobacco products in Finland.
(12) The effects of in vivo administration of native prostaglandin E2 (PGE) on the cycling status of the granulocyte-monocyte progenitor cell (CFU-GM) were examined in a mouse model.
(13) Mutational mosaicism was used as a developmental model to analyze 1,500 sporadic and 179 familial cases of retinoblastoma from the world literature.
(14) Time-series analysis and multiple-regression modeling procedures were used to characterize changes in the overall incidence rate over the study period and to describe the contribution of additional measures to the dynamics of the incidence rates.
(15) The disassembly of the synthetase complex is consistent with the structural model of a heterotypic multienzyme complex and suggests that the complex formation is due to the specific intermolecular interactions among the synthetases.
(16) Brown's model, which goes far further than those from any other senior Labour figure, and the modest new income tax powers for Holyrood devised when he was prime minister, edge the party much closer to the quasi-federal plans championed by the Liberal Democrats.
(17) It is concluded that in the mouse model the ability of buspirone to reduce the aversive response to a brightly illuminated area may reflect an anxiolytic action, that the dorsal raphe nucleus may be an important locus of action, and that the effects of buspirone may reflect an interaction at 5-hydroxytryptamine receptors.
(18) An experimental autoimmune model of nerve growth factor (NGF) deprivation has been used to assess the role of NGF in the development of various cell types in the nervous system.
(19) The data for the eubacterial ribosomes are in full agreement with the model of the 50S protein topography derived from immunological data.
(20) We present a mathematical model that is suitable to reconcile this apparent contradiction in the interpretation of the epidemiological data: the observed parallel time series for the spread of AIDS in groups with different risk of infection can be realized by computer simulation, if one assumes that the outbreak of full-blown AIDS only occurs if HIV and a certain infectious coagent (cofactor) CO are present.
Progenitor
Definition:
(n.) An ancestor in the direct line; a forefather.
Example Sentences:
(1) The effects of in vivo administration of native prostaglandin E2 (PGE) on the cycling status of the granulocyte-monocyte progenitor cell (CFU-GM) were examined in a mouse model.
(2) In healthy persons the supernatant of lymphocytes preincubated with PHA and ALG was found to show a stimulating effect to clonogenic properties of marrow progenitors, the mentioned effect being not in proportion to the concentration value.
(3) We therefore think that the detailed examination of CALLA(-) non-T non-B ALL cells using myeloid specific antibodies is helpful in clarifying the characteristics of myeloid precursors and the common bipotential stem cell of lymphoid and myeloid progenitors.
(4) The high levels of circulating progenitor cells in ALL and CLL patients clearly distinguish them from other cytopenic hematological malignancies, in which decreased progenitor cell levels have been demonstrated previously (acute myeloid leukemia, hairy cell leukemia).
(5) Studies on proliferation and differentiation of granulocyte-monocyte progenitor cells in Chediak-Higashi syndrome (CHS) were done on a 1-month-old patient, using the soft-agar bone marrow culture technique.
(6) Certain mouse and human hematopoietic progenitor cells also contain an aldehyde dehydrogenase that catalyzes the detoxification of aldophosphamide, but the specific identity of this enzyme remains to be established.
(7) Mouse spleen cells rich in erythroid progenitors were washed free of endogenous Epo and then incubated in the absence of Epo.
(8) The bone marrow differentials and numbers of granulocyte-macrophage progenitors (CFC-GM) were determined after irradiation with 1.5 Gy.
(9) However, the studies on 0-2A progenitor cells were carried out in bulk cultures of optic nerve, and so it was possible that other cell-cell interactions were required for differentiation in culture.
(10) In culture, GY30 cells sustain the production of granulocyte-macrophage progenitor cells (GM-CFU) but fail to support the survival of pluripotential stem cells (CFU-S).
(11) The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation.
(12) No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor.
(13) This is exemplified in lymphoma cells (chronic lymphocytic leukemia of B or T type, Sezary Syndrome, immunocytoma) that resemble mature and immunocompetent T and B cells, in T cell acute lymphoblastic leukemia (T-ALL) (equivalent to thymus cells) and in non-T ALL (corresponding to lymphoid progenitor cells in the bone marrow).
(14) We studied MDS-associated inhibitory activity, which inhibited colony formation in vitro of granulocyte-macrophage progenitors (CFU-GM).
(15) In contrast, populations containing BFUe yielded a striking (sixfold for CFUe; 23-fold for e-clusters) expansion of late progenitors in the presence of Epo.
(16) The stem cell loss immediately following 55Fe injection is in our interpretation caused by rapid differentiation along the erythroid pathway in a response that involves all progenitor populations.
(17) We report here that human IL-6 and IL-3 act synergistically in support of the proliferation of progenitors for human blast cell colonies and that IL-1 alpha reveals no synergism with IL-3 when tested against purified human marrow progenitors.
(18) In addition, we have examined the ability of these fibroblasts and their conditioned medium (CM) to induce differentiation of human hemopoietic progenitor cells.
(19) AF and its deacetylated form inhibited the development of macrophage and granulocytic colonies from progenitor cells in human bone marrow even at concentrations less than or equal to 10(-9)M. The disease suppressive activity of AF could result in part from the reduction of cell numbers in arthritic lesions and our findings provide a mechanism for this possibility.
(20) Spontaneously hypertensive rats (SH) with an increased number of red blood cells (RBC), microcytosis, and normal hemoglobin (Hb) concentration were used to study the effect of different manipulations of the erythron on erythropoietin production and on erythroid progenitor proliferation by bone marrow cells in order to gain insight regarding the regulation of erythropoiesis.