(a.) Producing only one kind of germs, or young; developing only in one way.
Example Sentences:
(1) Pairwise correlation between an affected parent and child is zero: The disease is monogenic (no major expression gene).
(2) The contribution of genes to the etiology of coronary heart disease (CHD) is highly significant even when monogenic hyperlipidemias are excluded.
(3) 10.6% of the children were found to have chromosomal abnormality, 26.5%--multifactorial pathology and 62.9% of children were affected by monogenic diseases.
(4) This article describes computer-based information-and-diagnostic system dealing with child hereditary diseases which makes in possible to organize automated consultative service on a wide range of monogene and chromosome syndromes.
(5) Here, it is shown that genetic variation in such 'molecular groupings' has clinical relevance, for example (1) in reproductive counselling for thalassaemia; (2) in heterozygosity where the affected enzymes are normally homopolymeric; (3) in clinical severity of 'monogenic' disease (e.g.
(6) No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.
(7) Conditions such as these may be exclusively monogenic, polygenic or environmental, but in most cases both genetic and environmental factors are involved.
(8) These data show that both the null and the normal genotypes have similar amounts of the enzyme protein, but the enzyme occurs mostly as insoluble or poorly soluble polymers in nulls, and the monogenic inheritance reported for the null alleles of the glu locus is likely to be for a factor encoded by another locus which affects directly or indirectly the solubility of the enzyme by increasing its polymerization into large quaternary structures.
(9) To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families.
(10) The molecular basis of this monogenic disease is the defective functioning of the cellular receptor for LDL that recognizes apo B. Lipoprotein(a) [Lp(a)] is a circulating lipoprotein that is structurally related to LDL, as it also contains apo B.
(11) These results indicate that timolol metabolism is partly under monogenic control of the debrisoquine-type.
(12) Six patients (four women and two men) with mild to moderate hypercholesterolemia, but with no clinical evidence of the disease being monogenic familial hypercholesterolaemia and who, over the previous 3 months on a rigidly controlled hypolipidaemic diet therapy, showed no reduction in plasma cholesterol levels, were recruited into a study to assess the metabolic effects of Pirozadil, a new nicotinic acid derivative.
(13) The method, which allows the determination of the mutations in both parental and fetal DNA on the same day, should have wide application to the carrier detection and prenatal diagnosis of monogenic diseases with heterogeneous molecular defects.
(14) The transport system is under monogenic control and is inducible.
(15) Parent-offspring occurrence of an accessory triradius and absence of the c triradius suggested monogenic control.
(16) In humans, the level of TPMT activity is inherited in a monogenic fashion.
(17) The recent techniques of polymerase chain reaction may allow DNA analyses in some cases: sexing or diagnosis of monogenic diseases.
(18) The possibility of pleiotropic monogenic control of the hereditary polyposis and primary colon cancer is checked up and confirmed.
(19) cdc16-116 is a monogenic recessive mutation unlinked to any previously known cdc gene of S. pombe.
(20) These advances will have an impact on fetal diagnosis of monogenic disorders for a number of reasons, the most important being the ability to use chorionic villus DNA taken in the first trimester to make a fetal diagnosis, no matter how tissue-specific the gene defect.
Offspring
Definition:
(n.sing. & pl.) That which is produced; a child or children; a descendant or descendants, however remote from the stock.
(n.sing. & pl.) The act of production; generation.
(n.sing. & pl.) Origin; lineage; family.
Example Sentences:
(1) No reversions to wild-type levels were observed in 555 heterozygous offspring of crosses between homozygous Campines and normals.
(2) In neither case has a significant elevation in inherited genetic effects or cancer been detected in the offspring of exposed individuals.
(3) For that reason we determine basal serum pepsinogen I (PG I) levels in 25 ulcerous patients and 75% of their offspring and to a control group matched by age and sex.
(4) The analgesic activity of morphine was assessed by the hot-plate technique in the offspring of female CFE rats that had received morphine twice daily on days 5 to 12 of pregnancy.
(5) The mothers of 87 male and female adolescents accepted at a counseling agency described their offspring by completing the Institute of Juvenile Research Behavior Checklist.
(6) Neither light nor electron microscopy revealed significant morphologic alterations in the cochlear elements of the exposed offspring.
(7) The relationships of birth weight and maternal diabetes to the development of obesity were examined at 5-19 yr of age in the offspring of Pima Indian women.
(8) The data of first 1000 first-born, non-malformed, mature (greater than or equal to 2500 g) offspring of participants in the Hungarian "Optimal" Family Planning Programme were evaluated.
(9) Subcutaneous polymorphic sarcomas were induced in 8 out 27 offspring of syrian golden Hamsters after treatment of pregnant mother animals at day 15 of gestation with Adenovirus 12.
(10) Here we show that the subsequent survival and reproductive success of subordinate female red deer is depressed more by rearing sons than by rearing daughters, whereas the subsequent fitness of dominant females is unaffected by the sex of their present offspring.
(11) The residual values were positively correlated in parent-offspring pairs and among sibs, both those presumed to be living together and those presumed to be living apart.
(12) The five offspring are ancestors of all known carriers.
(13) We have studied the effect of ampicillin and cloxacillin treatment of mice in the final week of pregnancy on the development of the lymphatic system of their offsprings.
(14) It was caused at the frequency close to 100% in dysgenic offsprings reared above 25 degrees C, of which gonads were morphologically clearly different from those of usual GD sterility, whereas there was no indication of GD-3 sterility at temperatures below 24 degrees C. Temperature sensitive period of GD-3 sterility was estimated to the prepupal stage by shift-down experiment.
(15) The effects of repeated N2O exposures were investigated for offspring of mice exposed to air or N2O (5%, 15%, or 35%) for 4 hours per day on days 6 through 15 of pregnancy.
(16) Whether normal individuals with such a duplication carry increased risk of having offspring with an obesity syndrome is yet to be determined.
(17) Offspring of marmosets reached adult values of 14CO2 exhalation at 8 days postnatally when using [14CO2]-methacetin as substrate and at 30 days postnatally using [14C2H5]-phenacetin in the breath test.
(18) The sample consisted of 102 Japanese families, each including both parents and one of their offspring, and on average all subjects had relatively well-aligned permanent dentitions.
(19) At Day 56, serum IgM concentrations were significantly lower in the low zinc offspring.
(20) Such conditions may influence the personality of offspring of deaf-mute people.