(a.) Producing only one kind of germs, or young; developing only in one way.
Example Sentences:
(1) Pairwise correlation between an affected parent and child is zero: The disease is monogenic (no major expression gene).
(2) The contribution of genes to the etiology of coronary heart disease (CHD) is highly significant even when monogenic hyperlipidemias are excluded.
(3) 10.6% of the children were found to have chromosomal abnormality, 26.5%--multifactorial pathology and 62.9% of children were affected by monogenic diseases.
(4) This article describes computer-based information-and-diagnostic system dealing with child hereditary diseases which makes in possible to organize automated consultative service on a wide range of monogene and chromosome syndromes.
(5) Here, it is shown that genetic variation in such 'molecular groupings' has clinical relevance, for example (1) in reproductive counselling for thalassaemia; (2) in heterozygosity where the affected enzymes are normally homopolymeric; (3) in clinical severity of 'monogenic' disease (e.g.
(6) No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.
(7) Conditions such as these may be exclusively monogenic, polygenic or environmental, but in most cases both genetic and environmental factors are involved.
(8) These data show that both the null and the normal genotypes have similar amounts of the enzyme protein, but the enzyme occurs mostly as insoluble or poorly soluble polymers in nulls, and the monogenic inheritance reported for the null alleles of the glu locus is likely to be for a factor encoded by another locus which affects directly or indirectly the solubility of the enzyme by increasing its polymerization into large quaternary structures.
(9) To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families.
(10) The molecular basis of this monogenic disease is the defective functioning of the cellular receptor for LDL that recognizes apo B. Lipoprotein(a) [Lp(a)] is a circulating lipoprotein that is structurally related to LDL, as it also contains apo B.
(11) These results indicate that timolol metabolism is partly under monogenic control of the debrisoquine-type.
(12) Six patients (four women and two men) with mild to moderate hypercholesterolemia, but with no clinical evidence of the disease being monogenic familial hypercholesterolaemia and who, over the previous 3 months on a rigidly controlled hypolipidaemic diet therapy, showed no reduction in plasma cholesterol levels, were recruited into a study to assess the metabolic effects of Pirozadil, a new nicotinic acid derivative.
(13) The method, which allows the determination of the mutations in both parental and fetal DNA on the same day, should have wide application to the carrier detection and prenatal diagnosis of monogenic diseases with heterogeneous molecular defects.
(14) The transport system is under monogenic control and is inducible.
(15) Parent-offspring occurrence of an accessory triradius and absence of the c triradius suggested monogenic control.
(16) In humans, the level of TPMT activity is inherited in a monogenic fashion.
(17) The recent techniques of polymerase chain reaction may allow DNA analyses in some cases: sexing or diagnosis of monogenic diseases.
(18) The possibility of pleiotropic monogenic control of the hereditary polyposis and primary colon cancer is checked up and confirmed.
(19) cdc16-116 is a monogenic recessive mutation unlinked to any previously known cdc gene of S. pombe.
(20) These advances will have an impact on fetal diagnosis of monogenic disorders for a number of reasons, the most important being the ability to use chorionic villus DNA taken in the first trimester to make a fetal diagnosis, no matter how tissue-specific the gene defect.
Polygenic
Definition:
(a.) Of or relating to polygeny; polygenetic.
Example Sentences:
(1) When power-transformed scores are used to eliminate skewness, there is evidence for one distribution and it is not possible to distinguish single gene from multifactorial (polygenic or cultural) inheritance.
(2) The polygenic control of diabetogenesis in NOD mice, in which a recessive gene linked to the major histocompatibility complex is but one of several controlling loci, suggests that similar polygenic interactions underlie this type of diabetes in humans.
(3) Inheritance of insulin-dependent diabetes mellitus (IDDM) is polygenic, and at least one of the genes conferring susceptibility to diabetes is tightly linked to the MHC.
(4) The M16 line of mice, selected for rapid postweaning gain, exhibits polygenically controlled obesity and hyperphagia.
(5) The maximum lifespan potential is a constitutional feature of speciation and must be subject to polygenic controls acting both in the domain of development and in the domain of the maintenance of macromolecular integrity.
(6) The pattern of familial clusters and the recurrence risk related to the number of affected relatives and to the severity of the disorder in the index patients support the theory of polygenic inheritance, a multifactorial-threshold aetiological model.
(7) The results showed that the low rate of bacterial clearance was recessive, that the rate of clearance was under polygenic control, and that an H-2-linked gene(s) plays a major role.
(8) The results are discussed in terms of 3 models: Lerner's concept of genetical homeostasis, additive and overdominance polygenic models.
(9) The writers agree with Mr Jiang sanduo's opinion that schizophrenic is a polygenic disease with a major dominant gene.
(10) Conditions such as these may be exclusively monogenic, polygenic or environmental, but in most cases both genetic and environmental factors are involved.
(11) The cultural model, the polygenic model, and the pseudopolygenic model share the common feature that all factors which are transmitted from parent to offspring may be represented by one parameter without any loss of information.
(12) The breeding genetic distance measure of a single locus (Carlson & Welch, 1977) is extended to polygenic traits.
(13) Polygenic variation can be maintained by a balance between mutation and stabilizing selection.
(14) Subsequent variance components analysis suggested that unmeasured polygenic loci and unmeasured shared environmental factors together account for at least an additional 36.7% of the variability in normalized fasting plasma glucose, with genes alone accounting for at least 27.3%.
(15) The posited codominant alleles represent the first single-locus component in the polygenic complexes creating susceptibility to seizures and epitomizes the small additive effects classically attributed to such genes.
(16) A new test of goodness of fit for the polygenic threshold model is proposed.
(17) Some of the abnormalities are due to detectable chromosome anomalies, while the majority of fetal abnormalities arise as a result of the interaction of polygenes and environmental factors.
(18) A general linear model of combined polygenic-cultural inheritance is described.
(19) At present, the strongest evidence is for a polygenic effect, not the effect of a single gene or gene locus.
(20) With non significant changes in triglycerides and HDL-C. We conclude that PP can be used as a complement of diet in the management of polygenic hypercholesterolemia.