(n.) A bitter white crystalline alkaloid found in opium, possessing strong narcotic properties, and much used as an anodyne; -- called also morphia, and morphina.
Example Sentences:
(1) Intrathecal injection of zopiclone potentiated morphine antinociception, while the intracerebroventricular injection of zopiclone failed to enhance morphine antinociception and the intracerebroventricular injection of flumazepil to antagonize the intraperitoneal-zopiclone-induced increase in morphine antinociception.
(2) As a consequence, similar response curves were obtained for urine specimens containing morphine or barbiturates.
(3) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(4) The results clearly show that the acute hyperthermia of unrestrained rats induced by either peripheral or central injections of morphine is not caused by activation of the pituitary-adrenal axis.
(5) We studied the effect of low-dose intrathecal morphine (0.00-0.20 mg) on pain relief and the incidence of side effects after cholecystectomy in 139 patients divided into eight groups according to intrathecal morphine dose: groups 1 (0.00 mg), 2 (0.04 mg), 3 (0.06 mg), 4 (0.08 mg), 5 (0.10 mg), 6 (0.12 mg), 7 (0.15 mg), and 8 (0.20 mg).
(6) In contrast, methysergide, ketanserin and 6-OHDA abolished the antisecretory effect of morphine.
(7) The analgesic activity of morphine was assessed by the hot-plate technique in the offspring of female CFE rats that had received morphine twice daily on days 5 to 12 of pregnancy.
(8) A marked analgesic effect was found after application of morphine hydrochloride patch containing Azone and N-methyl-2-pyrrolidone.
(9) From the results presented it appears that morphine produces a reciprocal change in the activity evoked in extensor and flexor reflex pathways.
(10) These marked steroid-induced changes in MS responsiveness could not be explained by altered pharmacokinetic disposition of morphine.
(11) Sixty-three patients were randomly divided into six groups by the following intrathecal morphine injection: group 1 (0 mg), group 2 (0.025 mg), group 3 (0.05 mg), group 4 (0.075 mg), group 5 (0.1 mg), and group 6 (0.125 mg).
(12) Additional studies on the blood to brain transport of human 125I-IL-1 alpha showed no modification by dexamethasone, morphine, indomethacin or alpha-melanocyte stimulating hormone.
(13) At both 24 h and 1 week, the inflamed paw showed pronounced supersensitivity to the antinociceptive action of morphine against noxious pressure.
(14) These results are discussed in relation to previous reports suggesting a common addiction liability for both morphine and alcohol in inbred strains of animals.
(15) An altered response to morphine was obtained; the effect of morphine on copulatory behavior was diminished while morphine's effect on exploratory activity was potentiated.
(16) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(17) Morphine administered intracerebroventricularly had little effect on sexual responding, even at doses which produced other side effects.
(18) Morphine-induced vasoconstriction was antagonized by high concentrations of of naloxone or mepyramine and may be due to release of histamine by a naloxone-sensitive mechanism.
(19) In particular, the first tetrapeptide had twice the activity of morphine, while the potency of the dipeptides was less than one twentieth that of morphine.
(20) Morphine addition to the PGE1-stimulated minces did not prevent or reverse stimulation of [3H]cAMP accumulation in any of the three experimental groups.
Opium
Definition:
(n.) The inspissated juice of the Papaver somniferum, or white poppy.
Example Sentences:
(1) The only entirely original stage work from this period was the spectacular one-man show Needles And Opium in 1991, which intermingled stories of love and addiction from the lives of Jean Cocteau and Miles Davis with an account of the meltdown of one of Lepage's own long-term relationships.
(2) Social changes going on in the society were reflected in choice of substance forms by younger people as compared to their elders (e.g., cigarettes vs pipes or cigars, heroin vs opium, manufactured vs village-produced alcohol).
(3) American frustrations burst into the open in October 2009 when serving and retired officials told the New York Times Karzai was a key player in Afghanistan's illegal opium trade, which helps fund the Taliban insurgency, while on the CIA payroll.
(4) A transformation of the corrupt economy could take up to two decades, and opium production is likely to climb beyond 2013's worrying levels before it falls again, said Jean-Luc Lemahieu, outgoing head of the UN office on drugs and crime in Afghanistan .
(5) Athletic elitism, the glorification of the human body, has succeeded religion as Marx's opium of the people.
(6) Cannabis and opium use has been in Nepal for centuries and in the past they did not pose much of a problem.
(7) In Henley, he encountered with interest the bookshop-owning lesbians who had taken opium with Cocteau, and a prim, elderly lady who had, in her youth, urinated regularly upon pioneering sexologist Havelock Ellis.
(8) But the ACMD research clearly found that the majority of people were not “parked” on opium substitution treatment for long periods of time, with only 10-15% receiving treatment for more than five years.
(9) With lots of water and fertile land, Sangin is perfect for growing the poppies currently being harvested for their opium sap.
(10) Subjects with a positive family history of opium use had an earlier age of onset than the subjects without a family history of opium use.
(11) Two ethnic groups in Laos were compared: the Hmong (or Meo), a tribal group with access to opium in their homes; and the Lao, a peasant people with more limited access, usually in opium dens.
(12) The time-course of changes in vegetative tests was studied in 47 men suffering from stage II opium dependence.
(13) Fifty-six addicted "world travelers" were studied at a treatment facility for opium addicts in Laos.
(14) Cash crops have diversified and replaced the former opium fields; the economy is moving away from a subsistence and cash economy to a mostly cash economy.
(15) They may well also be driving the Taliban effort in Helmand, since control of the opium-rich province would hand a major political advantage to whichever leader achieved it.
(16) Naltrexone blocked opioid-induced euphoria and decreased the craving for opium, but it did not inhibit drug usage.
(17) These studies contribute to the evidence that different cytochrome P-450-dependent mono-oxygenase systems are involved in the O- and N-dealkylation of opium alkaloids.
(18) Opium poppy latex contains a group of laticifer-specific, low-molecular-weight polypeptides called major latex proteins (MLPs).
(19) Communities raising opium poppy as a cash crop had highest crude rates of addiction (7.0-9.8 addicts per 100 people).
(20) The British prosecuted two opium wars in the cause of freedom to export and sell the produce of the East India Company's Bengal factories.