(adv.) Wicked in the extreme; abominable; iniquitous; atrociously villainous; execrable; detestably vile.
Example Sentences:
(1) The author of the new bill, Mike Rogers, the Republican chair of the House intelligence committee , has said it is aimed at tracking the nefarious activities of hackers, terrorists and foreign states, especially China.
(2) But remember: record companies can be callous and nefarious beasts."
(3) "If there is evidence that a particular American is involved in terrorism or other nefarious activity, then intelligence and law enforcement agencies should absolutely investigate that person aggressively, by showing that evidence to a judge and getting a warrant.
(4) For decades she’s been portrayed as a Lady Macbeth involved in nefarious plots, branded as “a congenital liar” and accused of covering up her husband’s misconduct, from Arkansas to Monica Lewinsky.
(5) In the fevered Daily Mail version, this fact suggests a nefarious and hyperactive court, up to mischief and rejoicing in 'overruling' national authorities, better to promote the interests of sex offenders and the homicidal.
(6) The talks came as the RAF dropped "precision" weapons on the Central Organisation for Electronic Research, described by the Ministry of Defence as "a cover for the regime's nefarious activities".
(7) Muscular dysfunction has a nefarious effect on subsequent facial growth.
(8) Thor: The Dark World sees Chris Hemsworth's Asgardian prince forced to team up with Tom Hiddleston's crafty Loki to take down an even greater threat, Christopher Eccleston's nefarious Malekith.
(9) A few minutes’ walks away, are the Catacumbas del Beaterio , part of a network of tunnels used for nefarious and religious purposes: short tours began last year.
(10) The optional measure was designed to “provide DHS greater clarity and visibility to possible nefarious activity and connections by providing an additional tool set which analysts and investigators may use”.
(11) Pushkov claimed Moscow and the EU were looking to solve the gas dispute between Russia and Ukraine but were being stymied by Washington's nefarious plans.
(12) Meanwhile, Donald Trump appeared to accuse Obama of harbouring a nefarious secret agenda on national security, linking the president to the mass shooting.
(13) Look, he’s the clear frontrunner, he’s been in six debates already, answered more questions from the media than any other candidate on the stage combined.” The Fox News press release that irked Trump and led to his withdrawal read: “We learned from a secret back channel that the Ayatollah and Putin both intend to treat Donald Trump unfairly when they meet with him if he becomes president – a nefarious source tells us that Trump has his own secret plan to replace the Cabinet with his Twitter followers to see if he should even go to those meetings.” Trump derided it as “a wise guy press release .
(14) Until recently Bitcoin had been a largely obscure currency used by the tech-savvy , libertarians wishing to thumb their noses at central bankers and people involved in more nefarious activities such as online gambling (often illegal in the US) or drug deals .
(15) Time was one would head to that area whenever a nefarious local had gone missing because, in time, the body would wash up in the River Lee.
(16) It also warned that “the conviction and detention of an individual for being in a declared area where no evidence has been provided of a nefarious intent could be arbitrary for the purposes of international human rights law”.
(17) Naturally, such features can be used for nefarious ends too, but Taaki says that's the price to be paid for freedom.
(18) While I’m not interested in a specific individual, I’m interested in the emergent behaviour of the crowd.” Facebook Twitter Pinterest City-simulation company Simudyne creates computerised models ‘with pretty pictures’ to aid disaster-response planning But what about more nefarious bodies who are interested in specific individuals?
(19) Via nefarious means I've watched two episodes of Lilyhammer , BBC4's brand new "not very good thing with subtitles we're hoping to keep The Killing audience enraptured with", where a New York mob boss (Steven Van Zandt) goes into hiding in Norway with hilarious results.
(20) We all know about the military uses of drones (bomb lots of people, surveillance), and how drones can be used for nefarious purposes (theft, voyeurism), but there are actually some pretty cool uses for drones too.
Pernicious
Definition:
(a.) Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked.
(a.) Quick; swift (to burn).
Example Sentences:
(1) To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects.
(2) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(3) Antibodies to parietal cells were found in 5 cases and 4 patients with pernicious anemia were detected.
(4) Reticulocytes of patients with pernicious anaemia on treatment and with haemolytic anaemia were shown to have higher folate levels than their corresponding mature cells.
(5) Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen.
(6) In pernicious anaemia the amount of enzyme is reduced and on this hypothesis the regulatory function impaired.
(7) Six patients without nervous system involvement had normal EEGs, 10 patients with spinal cord or peripheral nervous system involvement had normal or minimally abnormal EEGs, 17 of 19 patients with evidence of mental dysfunction had abnormal EEGs with the most consistent finding being an excess of theta slowing, and 19 patients with pernicious anemia and other neurologic diseases showed EEG findings reflecting the complicating disease process.
(8) This article details the pernicious odontostomatological effects provoked by antitumorous and immunosuppressive medication.
(9) This week, the resilience of Italy’s most pernicious problem – the mafia – was exposed once again when it was announced that Corleone’s town council was being dissolved by the order of Rome because it had been infiltrated by organised crime.
(10) Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms.
(11) Thus, the processing of progastrin adjacent to the active site of gastrin is more restrictively controlled than N-terminal processing during G-cell hypersecretion associated with pernicious anemia.
(12) The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin.
(13) They were found to have pernicious anemia (PA) and normal adrenal functions.
(14) The EEG was also a good indicator for detecting and confirming other intracranial disease processes unrelated to pernicious anemia.
(15) The endocrine tumours corresponded to the gastric carcinoids found in patients with long-lasting hypergastrinaemia due to pernicious anaemia or with a gastrinoma as part of the MEN I syndrome.
(16) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(17) 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed.
(18) Sixteen control subjects, 13 patients with pernicious anaemia, and four who had had total gastrectomy were studied.
(19) And so while it’s particularly pernicious that some parents pay for months, sometimes years, of tutoring to get their child through an exam that they might well otherwise fail, I know it’s because they are desperate to secure for their child any extra benefit going in a country that is becoming ever more unequal.
(20) This policy, which prevents many travellers and overseas residents from benefitting from one of the most effective prophylactic treatments on the market today, thereby indirectly causing a number of pernicious cases of malaria, is based on the unfounded, unproved premise that wide use of this drug would foster the development of méfloquine-resistance or on side-effects, which are in fact rarely of any consequence and always curable.