(1) GH8----GH1' NOEs demonstrate the presence of both A- and Z-form GH8 resonances in slow exchange on the NMR time scale.
(2) Examination of the NOESY data at 50- and 100-ms mixing times indicated that the kinds of observed NOEs can originate if each of the ten nucleotidyl residues belongs to the B-DNA family, i.e., C2'-endo,anti.
(3) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(4) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(5) The integration of these facilities with simple molecular graphics display routines allows modifications to the molecular conformation (such as bond rotations) to be performed, and the effect of these modifications on the NOE effects can then be rapidly calculated and easily visualized.
(6) The other two hyperfine-shifted signals produced no detectable NOEs to other resonances in the spectrum and were tentatively assigned to the remaining cysteinyl ligand (Cys-63).
(7) Amide solvent accessibility, NOE spectroscopy (NOESY) and rotating-frame NOE spectroscopy (ROESY) data strongly support the conclusion that the 12-26 and 15-23 peptides adopt in aqueous solution, a set of turn-like structures located around the central region of their corresponding polypeptidic chains, the same region where a beta turn exists in the native protein.
(8) Initial conformations for energy minimization were selected with the aid of the measured intensities of local nuclear Overhauser effects (NOEs) and other 1H-NMR data.
(9) Changes in chemical shifts and NOEs for wild type with bound phosphate compared with free wild type indicate that phosphate binds in the active site and that only small conformational changes occur on binding.
(10) The conformations of the cyclic hexapeptides in DMSO-d6 solution were determined by a number of homo- and heteronuclear two-dimensional n.m.r.-techniques including 2D rotating frame NOE-spectroscopy.
(11) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(12) Although the assignment of this dodecadeoxynucleotide may be completed without deuteriation, several NOEs must be assigned indirectly because of degeneracies in the chemical shift of the purine H8 protons.
(13) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(14) An approximate analysis of the NOE data assuming a single correlation time for the entire molecule and ignoring cross-relaxation effects was used to evaluate various models that have been proposed for the conformation of valinomycin.
(15) In addition, a number of tertiary NOEs have been identified which indicate that the global fold of the apoprotein at least partially resembles the four-helix bundle of the holoprotein.
(16) The resulting pattern of NOE cross-relaxation peaks when combined with previous 1D NOE results [Dugad, L. B., La Mar, G. N., Banci, L., & Bertini, I.
(17) The pyridazine acetylmethyl groups give NOEs to the C(alpha)H groups of the beta-hydroxy-N-methylvaline residues, showing that the acetyl groups, for at least some of the time, stretch over the depsipeptide ring, occluding one face of the molecule.
(18) Nuclear runoff analysis of the late region has demonstrated that up to 95% of transcripts which are initiated in the early region in nonpermissive cells terminate within the late region upstream of the late polyadenylation site (C. C. Baker and J. Noe, J. Virol.
(19) Its structure was elucidated by IR, UV, FAB-MS, and various NMR spectra (including NOE, BBD, INEPT, SR, COSY, NOESY etc.
(20) Three methods of obtaining distance constraints from 2D NOE peak intensities are examined: one entails a conservative use of ISPA, one assumes the ISPA to be fairly accurate, and one utilizes an iterative relaxation matrix method called MARDIGRAS (matrix analysis of relaxation for discerning the geometry of an aqueous structure), developed in this laboratory.
Nose
Definition:
(n.) The prominent part of the face or anterior extremity of the head containing the nostrils and olfactory cavities; the olfactory organ. See Nostril, and Olfactory organ under Olfactory.
(n.) The power of smelling; hence, scent.
(n.) A projecting end or beak at the front of an object; a snout; a nozzle; a spout; as, the nose of a bellows; the nose of a teakettle.
(v. t.) To smell; to scent; hence, to track, or trace out.
(v. t.) To touch with the nose; to push the nose into or against; hence, to interfere with; to treat insolently.
(v. t.) To utter in a nasal manner; to pronounce with a nasal twang; as, to nose a prayer.
(v. i.) To smell; to sniff; to scent.
(v. i.) To pry officiously into what does not concern one.
Example Sentences:
(1) Jonker kept sticking his nose in the corner and not really cooperating, but then came a moment of stillness.
(2) All of this in the same tones of weary nonchalance you might use to stop the dog nosing around in the bin.
(3) These data suggest that basophilic cell function in the superficial mucous layer in the nose is of greater significance in the development of nasal symptoms in response to nasal allergy than either mucociliary activity or nasal mucosal hypersensitivity to histamine.
(4) Body weight (BW) and nose-tail length were less in the hypoxic exposed (H) rats than in control (C) animals growing in air.
(5) It’s the same story over and over.” Children’s author Philip Ardagh , who told the room he once worked as an “unprofessional librarian” in Lewisham, said: “Closing down a library is like filing off the end of a swordfish’s nose: pointless.” 'Speak up before there's nothing left': authors rally for National Libraries Day Read more “Today proves that support for public libraries comes from all walks of life and it’s not rocket science to work out why.
(6) Segmental function was diminished an average of 67.8% in "noses" and 46.6% in "bridges".
(7) Most symptoms come from the ciliated airways (nose, paranasal sinuses, and bronchs) and from the middle ear.
(8) Although they were born at different periods of the year, the calves in all three groups had similar bacterial loads in their noses and tracheas when they were 1 day old (P greater than 0.05).
(9) Generated droplets were dried in line and led to an inhalation chamber from which the dry aerosol was inhaled using a nose or mouth inhalation unit.
(10) A review of the literature reveals that the numerous procedures now available to repair the nose had already been devised by the middle of the nineteenth century in Germany and France as well as in England.
(11) An initial nasal allergen challenge was followed by a rechallenge of the nose with allergen 24 h later using a lavage technique.
(12) Sometimes the way the MP [military policeman] holds the head chokes me, and with all the nerves in the nose the tube passing the nose is like torture,” Dhiab said in a legal filing.
(13) Transposition of prolabium not required in the definitive lip repair into the floor of the nose permits subsequent columellar construction.
(14) The symptoms might be due to increased parasympathetic activity to the nose with the release of vaso-secretory active substances.
(15) Most infections have flu-like symptoms including fever, coughing, sore throat, runny nose, and aches and pains.
(16) The observation of high levels of xenobiotic metabolizing enzyme activity in the olfactory mucosa has produced speculation on the functional significance of these enzymes in the nose.
(17) The results of numerous microbiological investigations of sputa, nose and throat swabs before and during the long-term study are interpreted under certain aspects and questioning.
(18) But a eurosnob is generally someone who only watches European soccer and looks down his or her nose at MLS.
(19) Pretreatment of the lower airways with inhaled atropine did not affect the magnitude of the changes in Ru after inhalation of OA through the nose but significantly attenuated the response of the lower airways.
(20) A significant decrease was shown for the difference in upper and lower lip pressures between nose breathing and mouth breathing, whereas there was a significant increase in pressure when the subject extended the head 5 degrees during mouth breathing.