(a.) Hurtful; harmful; baneful; pernicious; injurious; destructive; unwholesome; insalubrious; as, noxious air, food, or climate; pernicious; corrupting to morals; as, noxious practices or examples.
(a.) Guilty; criminal.
Example Sentences:
(1) At both 24 h and 1 week, the inflamed paw showed pronounced supersensitivity to the antinociceptive action of morphine against noxious pressure.
(2) "It looks as if the noxious mix of rightwing Australian populism, as represented by Crosby and his lobbying firm, and English saloon bar reactionaries, as embodied by [Nigel] Farage and Ukip, may succeed in preventing this government from proceeding with standardised cigarette packs, despite their popularity with the public," said Deborah Arnott, chief executive of the health charity Action on Smoking and Health.
(3) Noxious conditioning stimulation of a tooth led to a temporary decrease of the threshold for the jaw-opening reflex elicited from a contralateral or adjacent tooth; only conditioning stimulation at an intensity producing a marked arousal reaction was effective in this respect.
(4) Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital.
(5) Furthermore the noxious stimuli were completely ineffective from 10-15 min following the lidocaine injection while the non-noxious stimuli maintained their efficacy.
(6) Experiments using normal human subjects were performed to determine the effect of a putative analgesic, transcutaneous electrical nerve stimulation (TENS), on the perception of noxious thermal stimuli and also to examine critically the general applicability of signal detection theory (SDT) to the evaluation of analgesic agents.
(7) Rats inoculated in the tail-base with killed Mycobacterium butyricum developed an arthritic swelling and inflammation of the limbs accompanied by a hyperalgesia to noxious pressure applied thereto.
(8) Complete transection of the thoracic spinal cord eliminated both thermally elicited responses and orienting responses to noxious and tactile mechanical stimulation of the hindlimbs.
(9) This situation has contributed to exposure of sandblasters to hazardous levels of respirable free silica, and is reviewed here to prevent a continuation of the incompatibility of these and other standards for respiratory protection with the actual exposures to various noxious inhalants in the workplace.
(10) Effects of noxious electrical tooth stimulations and intraarterial administration of bradykinin or inhalation of volatile anesthetics on substance P content in the diencephalon-mesencephalon, pons-medulla and the spinal cord were examined in the rat.
(11) Surface airway epithelium is frequently injured by noxious inhaled agents, epithelial wound repair may be an important process by which the epithelial barrier integrity is maintained.
(12) Cough and bronchoconstriction are airway reflexes that protect the lung from inspired noxious agents.
(13) Pb also appeared to unmask an afterdischarge in some neurons following noxious mechanical stimulation.
(14) Neurons were first classified as on-cells if they fired faster during noxious pinch or as off-cells if they fired slower.
(15) These data indicate the antinociception from PAG stimulation is not equally distributed throughout the body, and that the intensity of the noxious stimulus influences the threshold for SPA.
(16) Profound inhibitions of the second phase were also produced by tactile segmental stimulation and noxious stimuli applied to widespread areas of the body (diffuse noxious inhibitory controls).
(17) It hasn't been reported that the neurons in somatosensory area I (SI) may respond to the noxious stimulation.
(18) Stimuli used to activate the cells orthodromically were graded innocuous and noxious mechanical stimuli, including sinusoidal vibration and thermal pulses.
(19) This cannot be explained by metabolic activation of the halogenated hydrocarbons but could be due to a noxious effect on the mitotoc spindle.
(20) Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats.
Pernicious
Definition:
(a.) Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked.
(a.) Quick; swift (to burn).
Example Sentences:
(1) To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects.
(2) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(3) Antibodies to parietal cells were found in 5 cases and 4 patients with pernicious anemia were detected.
(4) Reticulocytes of patients with pernicious anaemia on treatment and with haemolytic anaemia were shown to have higher folate levels than their corresponding mature cells.
(5) Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen.
(6) In pernicious anaemia the amount of enzyme is reduced and on this hypothesis the regulatory function impaired.
(7) Six patients without nervous system involvement had normal EEGs, 10 patients with spinal cord or peripheral nervous system involvement had normal or minimally abnormal EEGs, 17 of 19 patients with evidence of mental dysfunction had abnormal EEGs with the most consistent finding being an excess of theta slowing, and 19 patients with pernicious anemia and other neurologic diseases showed EEG findings reflecting the complicating disease process.
(8) This article details the pernicious odontostomatological effects provoked by antitumorous and immunosuppressive medication.
(9) This week, the resilience of Italy’s most pernicious problem – the mafia – was exposed once again when it was announced that Corleone’s town council was being dissolved by the order of Rome because it had been infiltrated by organised crime.
(10) Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms.
(11) Thus, the processing of progastrin adjacent to the active site of gastrin is more restrictively controlled than N-terminal processing during G-cell hypersecretion associated with pernicious anemia.
(12) The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin.
(13) They were found to have pernicious anemia (PA) and normal adrenal functions.
(14) The EEG was also a good indicator for detecting and confirming other intracranial disease processes unrelated to pernicious anemia.
(15) The endocrine tumours corresponded to the gastric carcinoids found in patients with long-lasting hypergastrinaemia due to pernicious anaemia or with a gastrinoma as part of the MEN I syndrome.
(16) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(17) 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed.
(18) Sixteen control subjects, 13 patients with pernicious anaemia, and four who had had total gastrectomy were studied.
(19) And so while it’s particularly pernicious that some parents pay for months, sometimes years, of tutoring to get their child through an exam that they might well otherwise fail, I know it’s because they are desperate to secure for their child any extra benefit going in a country that is becoming ever more unequal.
(20) This policy, which prevents many travellers and overseas residents from benefitting from one of the most effective prophylactic treatments on the market today, thereby indirectly causing a number of pernicious cases of malaria, is based on the unfounded, unproved premise that wide use of this drug would foster the development of méfloquine-resistance or on side-effects, which are in fact rarely of any consequence and always curable.