(a.) Hurtful; harmful; baneful; pernicious; injurious; destructive; unwholesome; insalubrious; as, noxious air, food, or climate; pernicious; corrupting to morals; as, noxious practices or examples.
(a.) Guilty; criminal.
Example Sentences:
(1) At both 24 h and 1 week, the inflamed paw showed pronounced supersensitivity to the antinociceptive action of morphine against noxious pressure.
(2) "It looks as if the noxious mix of rightwing Australian populism, as represented by Crosby and his lobbying firm, and English saloon bar reactionaries, as embodied by [Nigel] Farage and Ukip, may succeed in preventing this government from proceeding with standardised cigarette packs, despite their popularity with the public," said Deborah Arnott, chief executive of the health charity Action on Smoking and Health.
(3) Noxious conditioning stimulation of a tooth led to a temporary decrease of the threshold for the jaw-opening reflex elicited from a contralateral or adjacent tooth; only conditioning stimulation at an intensity producing a marked arousal reaction was effective in this respect.
(4) Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital.
(5) Furthermore the noxious stimuli were completely ineffective from 10-15 min following the lidocaine injection while the non-noxious stimuli maintained their efficacy.
(6) Experiments using normal human subjects were performed to determine the effect of a putative analgesic, transcutaneous electrical nerve stimulation (TENS), on the perception of noxious thermal stimuli and also to examine critically the general applicability of signal detection theory (SDT) to the evaluation of analgesic agents.
(7) Rats inoculated in the tail-base with killed Mycobacterium butyricum developed an arthritic swelling and inflammation of the limbs accompanied by a hyperalgesia to noxious pressure applied thereto.
(8) Complete transection of the thoracic spinal cord eliminated both thermally elicited responses and orienting responses to noxious and tactile mechanical stimulation of the hindlimbs.
(9) This situation has contributed to exposure of sandblasters to hazardous levels of respirable free silica, and is reviewed here to prevent a continuation of the incompatibility of these and other standards for respiratory protection with the actual exposures to various noxious inhalants in the workplace.
(10) Effects of noxious electrical tooth stimulations and intraarterial administration of bradykinin or inhalation of volatile anesthetics on substance P content in the diencephalon-mesencephalon, pons-medulla and the spinal cord were examined in the rat.
(11) Surface airway epithelium is frequently injured by noxious inhaled agents, epithelial wound repair may be an important process by which the epithelial barrier integrity is maintained.
(12) Cough and bronchoconstriction are airway reflexes that protect the lung from inspired noxious agents.
(13) Pb also appeared to unmask an afterdischarge in some neurons following noxious mechanical stimulation.
(14) Neurons were first classified as on-cells if they fired faster during noxious pinch or as off-cells if they fired slower.
(15) These data indicate the antinociception from PAG stimulation is not equally distributed throughout the body, and that the intensity of the noxious stimulus influences the threshold for SPA.
(16) Profound inhibitions of the second phase were also produced by tactile segmental stimulation and noxious stimuli applied to widespread areas of the body (diffuse noxious inhibitory controls).
(17) It hasn't been reported that the neurons in somatosensory area I (SI) may respond to the noxious stimulation.
(18) Stimuli used to activate the cells orthodromically were graded innocuous and noxious mechanical stimuli, including sinusoidal vibration and thermal pulses.
(19) This cannot be explained by metabolic activation of the halogenated hydrocarbons but could be due to a noxious effect on the mitotoc spindle.
(20) Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats.
Virulent
Definition:
(a.) Extremely poisonous or venomous; very active in doing injury.
(a.) Very bitter in enmity; actuated by a desire to injure; malignant; as, a virulent invective.
Example Sentences:
(1) The combined analysis of pathogenesis and genetics associated with the salmonella virulence plasmids may identify new systems of bacterial virulence and the genetic basis for this virulence.
(2) Escherichia enterotoxigenic strains, Yersinia enterocolitica and Salmonella typhimurium virulent strains, Campylobacter jejuni clinical isolates possess more pronounced capacity for adhesion to enteric cells of Peyer's plaques than to other types of epithelial cells, which may be of importance in the pathogenesis of these infections.
(3) The results are consistent with our previous suggestion that lethality for virulent SFV infection results from a lethal threshold of damage to neurons in the CNS and that attenuating mutations may reduce neuronal damage below this threshold level.
(4) The results point out the importance of detecting specific virulence factors before incriminating water as a source of human diarrhea.
(5) We put forward the hypothesis that the agglutinability in acriflavine, together with the PAGE profile type II, may be associated with particular structures responsible for virulence.
(6) One mutant, BS260, was completely noninvasive on HeLa cells and mapped to a region on the 220-kb virulence plasmid in which we had previously localized several avirulent temperature-regulated operon fusions (A.E.
(7) The proteins of two HEV isolates, one apathogenic (HEV-A) and one virulent (HEV-V), resembled each other in most respects.
(8) The geometric mean titers of anti-Shigella antibodies to virulence plasmid-associated antigens in milk received before infection were eightfold higher in infants who remained well than in those in whom diarrhea developed.
(9) Presented are the clinical, pathologic, and virulence features of sudden death due to Group A beta-hemolytic streptococcus.
(10) Some of these strains have been used by investigators to study gonococcal virulence.
(11) With the faster rate of proliferation there was a corresponding increase in virulence.
(12) On average, clinical isolates were not more virulent than fecal isolates.
(13) Since the four determining coefficients may change over evolutionary time-scales, the mathematical results together with a natural selection argument proves that virulence gamma 2 attenuates.
(14) It also devalues the courage of real whistleblowers who have used proper channels to hold our government accountable.” McCain added: “It is a sad, yet perhaps fitting commentary on President Obama’s failed national security policies that he would commute the sentence of an individual that endangered the lives of American troops, diplomats, and intelligence sources by leaking hundreds of thousands of sensitive government documents to WikiLeaks, a virulently anti-American organisation that was a tool of Russia’s recent interference in our elections.” WikiLeaks last year published emails hacked from the accounts of the Democratic National Committee and John Podesta, chairman of Hillary Clinton’s election campaign.
(15) Understanding the molecular biology of a virulence factor also provides information about potential targets for future therapies and preventive modalities.
(16) This ability may be associated with virulence, because an attenuated strain of L. pneumophila fails to multiply within this protozoan, whereas a virulent strain increases 10,000-fold in number when coincubated with T. pyriformis.
(17) Combinations of factors were generally more predictive for defining virulent clones, particularly in infants defined as being at normal risk of developing septicaemia.
(18) Strain IIBNV6, however, complemented with all virulent strains tested.
(19) Measurable activity on day 7 depended on infectious virus dose, virus virulence, and non-H-2 genetic background of the host.
(20) A related mechanism is proposed for the control of the virulence of animal viruses.