(n.) Originally, an elf's child; a changeling left by fairies or goblins; hence, a deformed or foolish child; a simpleton; an idiot.
Example Sentences:
(1) Big OAF was converted to little OAF by equilibration in 1 M NaCl or 2 M urea.
(2) Outside, there’s no sign of life except one bearded oaf on a chopper and a kid at the back door, holding a picture of Hot Fuss-era Brandon Flowers , praying for a brief encounter.
(3) The effect of interleukin-1 beta, the major component of osteoclast-activating factor (OAF), on bone formation by fetal rat osteoblast-rich cells was investigated.
(4) Recent studies show that osteoclast activating factor (OAF) is homologous to IL-1B.
(5) The resorption response to OAF also resembles that of PTH in having a steep dose response curve and being only transiently inhibited by calcitonin and partially inhibited by increasing medium phosphate concentration.
(6) Spleen cells treated with mitogens produce a potent bone-resorbing factor called osteoclast-activating factor (OAF).
(7) In contrast, supernatant fluids from concanavalin A (Con-A)-activated murine spleen cell cultures (murine osteoclast-activating factor; OAF) consistently and significantly induced a 3- to 5-fold stimulation of bone resorption in this system.
(8) OAF production is probably related to the nature of hydrocarbons in the air.
(9) Calcium release was significantly increased for all agents between 12 and 24 h. It is concluded that bone resorption by 1,25(OH)2D3, OAF, and PGE2 is mediated primarily by increased activity of existing osteoclasts similar to PTH activation.
(10) The presence of bactericidal compounds (open air factor = OAF) could be demonstrated on several days and quantitated in relative units of OAF concentration.
(11) The current studies were designed to produce monoclonal antibodies against OAF for use in the subsequent design of immunoassays for OAF in clinical samples.
(12) In this study we examined the relationship between the lymphocyte and monocyte in OAF production.
(13) The lymphokine osteoclast-activating factor (OAF) was purified to homogeneity.
(14) These results indicate that prostaglandin synthesis is necessary for OAF production.
(15) Are there really "nine sleeps 'til new Who" you gurgling oaf?
(16) Bones from mi mice showed a generalized resorption defect with decreased spontaneous or control resorption and failure to respond to parathyroid hormone (PTH), prostaglandin E2, 1,25 dihydroxy vitamin D3, vitamin A, or osteoclast activating factor (OAF) from human peripheral leukocytes or mouse spleen cells.
(17) OAF release was stimulated by pokeweed mitogen and concanavalin A as well as by phytohemagglutinin.
(18) When PGE1 and PGE2 (0.1 microM) were added exogenously to the enriched lymphocyte population, OAF release occurred after stimulation with PHA.
(19) We have further characterized osteoclast activating factor (OAF) using a bioassay for bone resorption which utilizes the release of previously incorporated (45)Ca from fetal rat long bones in organ culture.
(20) The demonstration of increased osteoclast activating factor (OAF) derived from the cultured myeloma cells from each case suggests that the secretion of OAF and immunoglobulin are unrelated.
Simpleton
Definition:
(n.) A person of weak intellect; a silly person.
Example Sentences:
(1) Reading your post I couldn't help but think tonight's simpletons had undergone a similar experience."
(2) But these simpletons are absolutely determined to find their seat.
(3) There’s a really big willingness to help here in Germany and a mind-boggling number of people that are doing lots for refugees, who are not racist, and I think it’s their voice that should be dominant rather than a handful of simpletons who think they should stir up hatred.” This article was amended on 7 August 2015 to correct the name of the news programme on which Reschke made her comments
(4) Maybe because I am a simpleton and sometimes can only process what I can see – the actual sky, rather than invisible cyberspace in which data blips through fibre-optic cables.
(5) George W. Bush was a Texan simpleton who took more time playing golf on his computer than deciding on executions while governor.
(6) Responses to Doyle’s tweet included one from another Twitter user who asked : “What has a Muslim woman in Croydon, got to do with the horrific events in Belgium, you simpleton?” Another, referring to the far-right extremist Anders Behring Breivik, asked : “Did anyone accost you on the streets of Croydon after the Brevik shooting in Norway?
(7) Which is also to say, for younger visitors, that the exhibition could even be seen to reduce Diana to the big-spending simpleton who was castigated in Anthony O’Hear’s revisionist essay of 1998, as shallow and self-obsessed.
(8) He is by no means the simpleton played by Peter Sellers in Being There, but, like Gardiner, every utterance, however gnomic, is now thought to contain a greater truth.
(9) And Navracsics’ hastily put together statement from yesterday seems to only repeat the same category error, a simpleton bureaucrat mantra trying to dodge the absurdity of the EU apparently having no responsibility to give any support to the EU’s own youth orchestra.
(10) These use the character of Lennie, the gentle simpleton who doesn't know his own strength from Steinbeck's 1937 novel Of Mice and Men, as a benchmark, with the court writing: "Texas citizens might agree that Steinbeck's Lennie should, by virtue of his lack of reasoning ability and adaptive skills, be exempt" .
(11) "I was a simpleton last Saturday evening at Melbourne Park."
(12) My husband is pointing out, veeerrryy slowly, as if to a simpleton, that this would involve us trebling our current mortgage.
(13) A dverts for insurance comparison websites have long treated the British public like a shower of infantilised simpletons.
(14) Top Gear's Jeremy Clarkson rapped over "special needs" joke This time it's media regulator Ofcom tut-tutting after Clarkson describes the Ferrari F430 Speciale as "a bit wrong ... that smiling front end ... it looked like a simpleton ... [it] should have been called the 430 Speciale Needs".
(15) I liked the idea of an island with a vocation – all islands should have one, surely – and Tico took great pleasure in instructing me in the difference between primary and secondary Atlantic rainforest (simpleton that I am, I thought all forest was good, but Tico tut-tutted every time we passed a coconut palm), and even more pleasure in skipping up the 990m Pico do Papagaio while I lumbered behind.