(v.) That which stands in the way, or opposes; anything that hinders progress; a hindrance; an obstruction, physical or moral.
Example Sentences:
(1) Since the first is balked by the obstacle of deficit reduction, emphasis has turned to the second.
(2) If women psychiatrists are to fill some of the positions in Departments of Psychiatry, which will fall vacant over the next decade, much more attention must be paid to eliminating or diminishing the multiple obstacles for women who chose a career in academic psychiatry.
(3) Counselors who serve pregnant US teens face a number of obstacles in communicating adoption as a positive alternative.
(4) A major obstacle to the characterization of the latter two mechanisms has been the lack of suitable model systems expressing only a single nucleoside transport activity.
(5) These observations suggest that refractive anomalies such as anisometropia that limit high frequency spatial resolution and binocular integration can present a major obstacle to the postnatal development of binocular vision.
(6) The initiation of clinical trials on islet transplantation as a possible therapeutic approach for human diabetes had been blocked by 2 major obstacles.
(7) Venous ectasias and varices which can be encountered, associated with DVA constitute an acquired feature in relation to a venous outlet obstacle.
(8) Despite these obstacles, new technologies, coupled with educational efforts, should allow the computer to emerge as a crucial aid to clinicians in the decade ahead.
(9) Yet experience has disclosed an obstacle to understanding the relationship between cervical cancer and OC use--cervical cancer may be caused by the human papilloma virus transmitted by sexual intercourse.
(10) In this paper something is given of their evolution, diversity, aims and activities; and of the important role they now play in many instances, as well as some of the obstacles to collaboration, co-ordination and integration at different levels of operation--internationally, nationally and locally.
(11) It is no obstacle to perform pre- and postoperative radio- and chemotherapy.
(12) Obstacles to successful treatment include an erratic schedule, mistrust of authority, and uncooperative or aggressive behavior.
(13) One of the main obstacles for the introduction of PCR method to identify HIV1 proviral DNA in routine diagnostic laboratories is the use of radiolabelled oligodeoxynucleotide probes.
(14) Digital culture has hardly helped, adding revenge porn, trolls and stranger-shaming to the list of uncomfortable modern obstacles.
(15) She feared her chances of being offered a place would be diminished by a Brexit vote, and the practical considerations like a visa and funding would be more of an obstacle.
(16) It goes without saying that this won't be easy to achieve, and there are many obstacles to be overcome.
(17) Armstrong recognised no obstacle to his ambitions – not morality, not the law.
(18) Where foreign policy and defence are concerned, Britain’s desire to be taken very seriously is the chief obstacle to it being taken more seriously.
(19) The presence of calcifications within the thyroid cartilage is the major obstacle to US imaging of the larynx and is directly related to age; indeed, only 40% of subjects can be examined at the age of 70.
(20) Facebook Twitter Pinterest Britain needs to talk about the R-word: racism It is also a wakeup call to those who recognise racism only when it is played out like a scene from Django Unchained , those who think that racism has to be some vulgar incident perpetrated only by the backward, ignorant and poorly educated, those who believe that racism has to be an act, rather than a complicated and intangible framework that sets up obstacles.
Unfavorable
Definition:
(a.) Not favorable; not propitious; adverse; contrary; discouraging.
Example Sentences:
(1) Recently reported unfavorable clinical results (i.e., a high incidence of pain) have led to the discontinuation of one trial of porous polyethylene.
(2) By treatment of mice with anticancer agent CY or gamma ray irradiation, unfavorable side effects usually occurred to impair hematopoietic organs, causing bone marrow disorder.
(3) From the previously observed results of preferential interactions for salting-out salts with proteins, it was shown that the free energy of the protein is increased by addition of the salts and this unfavorable free energy is smaller for the proteins bound to the columns because of their smaller surface area exposed to solvent; i.e., the bound form of the proteins is thermodynamically more stable.
(4) Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6-12 months, and where relapse cannot be prevented.
(5) Since liver metastases are the most common unfavorable outcome of colon cancer, ongoing trials using liver-directed treatment (perfusion, irradiation) should be followed with interest.
(6) Extracorporeal shockwave lithothripsy was very helpful in facilitating extraction of stones in unfavorable locations or located above the severe stricture.
(7) A positive deltaS compensates for an unfavorable positive deltaH so that the overall reaction is exergonic.
(8) The results show that conversion of Glu-208 to Gln greatly enhanced substrate binding, implying that Glu-208 interacts unfavorably with the substrate's ground state, preventing its optimal fit to the active site.
(9) Our data suggest that prostaglandin gel cervical ripening and induction of labor and delivery by 42 weeks' gestation may be the most appropriate management for patients with well-established gestational age and an unfavorable cervical examination.
(10) When patients with and without ST shift on Holter monitor ECG were compared, an unfavorable outcome was found in 48% versus 20% (p less than 0.005), multivessel disease in 76% versus 54% (p less than 0.01) and left main coronary stenosis in 18% versus 4% (p less than 0.05).
(11) Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB.
(12) Myocardial transformation, along with its energy economizing effect, failed to compensate for unfavorable energetic consequences of structural dilatation and therefore the reduced ventricular efficiency is assumed to be another deleterious factor in the dilated failing heart.
(13) So far we believe that loss of hearing caused during these operations is mainly due to the unfavorable location of the cochlear blood supply through the meatus.
(14) Hypodiploidy is therefore an unfavorable karyotypic feature in childhood ALL.
(15) Hormone therapy was not indicated in these cases as it could lead to unfavorable results: decreased indices of definitive growth resulting from the formation of antibodies to the growth hormone.
(16) The course of gonarthrosis was unfavorable in that a majority of the cases became worse over the years and some also developed pain at rest.
(17) The favorable effects of up to 25% toasted soybean meal and 3% licorice root extract on the levels of the four enzymes, without unfavorable changes in clinical parameters, might account in part for the chemopreventive activities of these additives.
(18) The following signs in the preoperative radiographs were predictive of unfavorable outcome: small head fragment, comminution of the calcar femorale, and varus angulation of the head.
(19) When Rappaport's classification was used, division of unfavorable histologies into histiocytic and non-histiocytic groups provided only marginal significance in MVA.
(20) The outcome was unfavorable and the response to anticonvulsant drugs was poor.