(a.) Pertinaciously adhering to an opinion, purpose, or course; persistent; not yielding to reason, arguments, or other means; stubborn; pertinacious; -- usually implying unreasonableness.
(a.) Not yielding; not easily subdued or removed; as, obstinate fever; obstinate obstructions.
Example Sentences:
(1) The patient was a forty-five-year-old female who had been troubled by obstinate Raynaud's phenomenon for ten years before the definite diagnosis of pulmonary hypertension was made.
(2) The whole proves his introversion, ambivalence, hypersensitivity, obstinancy, anxieties, behavioral anomalies, a life rich in fantasies and his underestimation of his own literary work.
(3) Soon my piano lessons had turned into me, an obstinate 11-year old, demanding that my neighbour teach me ever-more intricate DOS commands.
(4) Peritoneal pseudomyxoma has several main features: it is insidious, recurrent, obstinate and severe.
(5) Adamant avoidance of division of primary clinical responsibility among cooperating specialists and clinician obstinancy when dealing with third parties can help prevent suicides.
(6) When an obstinate irritable colon is present, a diagnostics of neuroses is indicated.
(7) Twenty-two cases 23 eyes with obstinate stromal keratitis treated by combination of traditional Chinese and Western medicines are reported in this paper.
(8) Scores of people, including comedian Mark Thomas and wilderness hiker Cameron McNeish, have become joint owners of an acre of land previously owned by Michael Forbes, the quarryman and salmon netsman who has become Trump's most famous and obstinate opponent.
(9) The results show the possibility that recombinant human interleukin-1 alpha could be of help for treating obstinate infections not successfully treated with antimicrobial agents alone.
(10) "[The officials] have become obstinate – they are seeking just different ways to mistreat my mother and us as her children," he said.
(11) During the first weeks of the rheumatoid arthritis the following symptoms are found: articular syndromes, more frequently in form of obstinate polyarthralgias, mono-oligoarthritis, accompanied by morning rigidity and accelerated BSR as well as impairment of the general condition.
(12) In a study for the recognition of the urodynamics of the detrusor after administration of the anticholinergic drug Mictonorm 14 patients with obstinate urge symptoms were examined.
(13) But these factors become important when patients, particularly debilitated patients, are infected acutely or chronically with some of the more obstinate bacteria.
(14) Back by the obstinately uninflated elephant, Simon Vose clambered in to his van and set off on another callout for his house maintenance business.
(15) These results show the possibility that KW-2228 could be of use in treating obstinate infections not successfully treated with an antimicrobial agent alone.
(16) Instead, the focus has been on the objective question: could an obstinate and prejudiced person have honestly based the comment made by the defendant on the facts on which the defendant commented?
(17) But with a very strong El Niño driving record global temperatures and a huge patch of hot water, known as “the Blob” , hanging obstinately in the north-western Pacific, things look far worse again for 2016.
(18) Such querulous, opinionated persons are obstinate "bellyachers" who "stick to their guns" and imaginary legal positions to the extent of being a general nuisance.
(19) Three years later, he provoked intense controversy with the publication of Haig: The Educated Soldier, which was sharply at odds with the popular view that the first world war had been the supreme example of "mud, blood and futility", with British generals depicted as callous, obstinate and incompetent.
(20) The knowledge of these diseases is a prerequisite to the causal and lasting treatment of patients affected by the obstinate and occasionally even painful symptom of the burning tongue.
Refractory
Definition:
(a.) Obstinate in disobedience; contumacious; stubborn; unmanageable; as, a refractory child; a refractory beast.
(a.) Resisting ordinary treatment; difficult of fusion, reduction, or the like; -- said especially of metals and the like, which do not readily yield to heat, or to the hammer; as, a refractory ore.
(n.) A refractory person.
(n.) Refractoriness.
(n.) OPottery) A piece of ware covered with a vaporable flux and placed in a kiln, to communicate a glaze to the other articles.
Example Sentences:
(1) During electrophysiologic study, the effect of propafenone on the effective refractory period of the accessory pathway was determined, as well as its effect during orthodromic atrioventricular (AV) reentrant tachycardia and atrial fibrillation.
(2) Some evidence has shown that platelet crossmatching is useful in multitransfused patients with hypoplastic bone marrows who are refractory to platelet therapy through alloimmunization.
(3) The purpose of this study was to determine the effect of pretreatment with indomethacin on the refractory period to hypertonic saline-induced bronchoconstriction.
(4) This quantitative characterization of the properties of conduction and refractoriness of both the accessory pathway and ventriculoatrial conduction system and the relation between these characteristics and the accessory pathway location in ART patients provides additional insight into the prerequisites for the initiation and maintenance of this rhythm disturbance.
(5) Lisinopril increases cardiac output, and decreases pulmonary capillary wedge pressure and mean arterial pressure in patients with congestive heart failure refractory to conventional treatment with digitalis and diuretics.
(6) Extracorporeal photopheresis (ExP) was administered every other week in an outpatient setting to four patients with chronic refractory psoriasis vulgaris without arthropathy.
(7) Populations of B. globosus and B. nasutus from Dar es Salaam were refractory.
(8) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(9) We present in this preliminary report the early results of therapy for refractory leukemia with an intensive preparative regimen for bone marrow transplantation including etoposide, cytosine arabinoside, cyclophosphamide, and fractionated total body irradiation.
(10) Amiodarone was able to suppress the premature ventricular beats, depress conduction and prolong refractoriness in both, the AV node and accessory pathway to prevent recurrences of atrioventricular reentry.
(11) Once initiated, this refractory state continues to develop even after removal of the light source and is essentially complete within 30 min.
(12) At lower frequencies of stimulation the heart beat is increased to rates dependent on interaction between the time course of the hyperpolarization and the refractory period of the heart.
(13) The results indicate that the conditions which inhibit the initiation of development are present in the Malpighian tubules and not in the midgut of the refractory mosquitoes.
(14) Parenteral cyclophosphamide or corticosteroid pulses should be reserved for cases with vasculitis or refractoriness to conventional drugs.
(15) These data suggest that in terms of prolactin release, prolactin producing tumour cells are intrinsically refractory to hypo thalamic dopaminergic signals.
(16) Pirmenol increased the atrial effective refractory period, but had little effect on conduction in the atrioventricular node and His-Purkinje system.
(17) Estramustine phosphate may be given safely for a prolonged period and has a place in the treatment of advanced prostatic cancer refractory to hormonal therapy.
(18) One or more of the followin factors were present in the "high-risk" group: ventricular dysfunction--ejection fraction less than 0.4, preinfarction angina, evolving infarction, recent infarction (less than 2 weeks), and refractory ventricular tachyarrhythmia.
(19) Although video urodynamics is the state-of-the-art modality for evaluating complex or refractory neurogenic bladder, the practicing radiologist with an understanding of this condition can detect many radiographic changes in the lower urinary tract that suggest neurogenic dysfunction of various types.
(20) Tinidazole (not available in the United States) may be effective in curing refractory cases of metronidazole resistance.