(1) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(2) She added: “We will continue to act upon the overwhelming majority view of our shareholders.” The vote was the second year running Ryanair had suffered a rebellion on pay.
(3) T cells admixed in the germinal centers were overwhelmingly of the T-helper type.
(4) Unfortunately for the governor, he could win both states and still face the overwhelming likelihood of failure if he doesn't take Ohio, where the poll found Obama out front 51-43.
(5) In Britain, the European election is overwhelmingly seen through the prism of domestic politics.
(6) Photograph: Christopher Thomond for the Guardian Asked if Watson should seek to refresh his mandate after Corbyn’s overwhelming victory among members, McCluskey added: “Well, if Tom wants to try to refresh his mandate it would be interesting to see what happens.” Watson said it was time “to be proud of our party”, because the Conservatives were beatable and the prime minister, Theresa May, could call an election any time.
(7) The government acknowledged it had been overwhelmed by the devastation from the deadliest quake in Nepal in over 80 years.
(8) He made me laugh and cry, and his courage in writing about what he was going through was sometimes quite overwhelming.
(9) Although alpha 1-antiprotease (alpha 1-AP) binds and inactivates NE and is the major antielastase of the lower respiratory tract, antielastase defenses may be overwhelmed in CF, leading to progressive lung damage.
(10) And HAP has shown that the key finding that debt slows growth was driven overwhelmingly by the exclusion of four years of data from New Zealand.
(11) Cathepsin D-like acid proteinase existed overwhelmingly in the mucosal layer and was hardly detected in the gastric juice.
(12) Hence, reaction of chemical carcinogen with nuclear DNA is possible only when the cell is overwhelmed leading to cell death, or following a temporary breach of the nuclear membrane control points, but the DNA damage in the latter is totally reparable.
(13) The facts are clear: the overwhelming majority of EU citizens in Britain are contributors, not freeloaders.” But that was not the official position of any of the parties involved, so it went mostly unsaid.
(14) Of 54 patients with poor-grade aneurysms, ventriculostomy was placed in 47 (87.0%) and yielded high ICP's in the overwhelming majority, with the mean ICP being 40.2 cm H2O.
(15) There is overwhelming evidence, today, that such factors are involved in the manifestation of acute as well as chronic, non-specific as well as well as specific inflammation.
(16) Mobile phone networks, overwhelmed by demand, were down for hours, with authorities advising people to use email or text messages instead.
(17) The immunity was enacted by an overwhelming bipartisan vote, with the support of leading Democrats including Barack Obama, who had promised - when seeking his party's nomination - to filibuster any bill that contained retroactive telecom immunity.
(18) There’s an overwhelming sadness among kids like that who have been kept there for a very long time.
(19) Panic attacks would overwhelm her periodically and she experienced regular “ scanxiety ” – the feelings of dread that grip patients before new tests.
(20) In the meantime, Malaysia Airlines’ overwhelming focus will be the same as it has been from the outset – to provide the families with a comprehensive support programme.
Overwrought
Definition:
() of Overwork
(p. p. & a.) Wrought upon excessively; overworked; overexcited.
Example Sentences:
(1) With the students back, parliament in session and that Killers album slowly being revealed as an overwrought dud, what better time for the greatest minds of their generation to go down the pub and invent a new genre?
(2) No one assumes that New Zealand will have an impact in South Africa, yet insouciance is an asset when other sides are so overwrought.
(3) Lost in all of the cyber-Armageddon rhetoric is Sony’s own negligent security practices, which is maybe where some of Hollywood’s own overwrought ire should be pointed, rather than blaming journalists for reporting.
(4) The season premiere, which aired on Sunday, has everything its returning fans demand: shocks and quips and china sauce-boats, and overwrought manners and hats.
(5) One morning we had a text vote for whether or not to play Curtain Call by the Damned, in its full 18 minutes of overwrought gothic glory.
(6) Overwrought tell-all memoirs are liable to elicit this response even from those who are not directly affected.
(7) One of the older ones actually burst into tears, somewhat overwrought by the whole experience.
(8) I, for one, enjoyed the overwrought silliness of series two.
(9) He is overwrought and half-asleep, and so Forster risks giving him purple cravings for "big spaces where passion clasped peace, spaces no science can reach, but they existed for ever, full of woods some of them, and arched with majestic sky and a friend".
(10) The 34-year-old was as overwrought as any testosterone-maddened youngster but could still have contrived a triumph.
(11) It’s as if too many overwrought, mainly male, pub bores have been allowed to take over what is, never forget, a vote for the whole country’s future.
(12) Should he ever need alternative employment - and, after all, he might - Brown might consider a career writing poems in overwrought Hallmark greetings cards.
(13) The understandable but overwrought attacks on Saif Gaddafi that followed his embrace of his father, clan and regime in Tripoli at the start of the uprising, have made it extremely difficult to pursue a diplomatic track in Libya.
(14) All of which she squares up to with Boudiccan fortitude (overwrought grandma years).
(15) There is a danger for Franzen, that an author who is not a native user of the internet will be exposed in the way in which he writes about it, and there are a few false notes in Purity; an off use of the term “going viral”, a tin-eared reference to Jeff Bezos, and the overwrought phrase “moused and clicked” to describe the activity of industrious interns at their desks.
(16) Whether overwrought or merely unlucky, Liverpool could not capitalise on initial ebullience and fell behind nine minutes from the interval.
(17) In a number of later films, he is often seen trying to direct some overwrought superstar.
(18) It certainly paved the way for two acclaimed debut albums in the trip-hop vein – Portishead's dense and sometimes overwrought Dummy (1994) and Tricky's darkly mesmeric Maxinquaye from 1995 – as well as the more well-mannered beats of acts such as Morcheeba and Zero 7.
(19) For me, it’s just indulging my passion for overwrought choreography, pure performance and cheesy music.
(20) I felt odd: overtired, overwrought, unpleasantly like my brain had been removed and my skull stuffed with something like microwaved aluminium foil, dinted, charred and shorting with sparks.