(n.) A small South American rodent (Coelogenys paca), having blackish brown fur, with four parallel rows of white spots along its sides; the spotted cavy. It is nearly allied to the agouti and the Guinea pig.
Example Sentences:
(1) In a survey of CT-scanner utilization, data from all machines operating in the PACA Region in 1986, showed that the mean activity was 6,080 examinations per machine.
(2) Thus, PacA and PacB are two essential bacteriophage proteins required for recognition and cleavage of the P1 packaging site.
(3) To test this hypothesis, membranes of MIA PaCa-2 cells, a human dedifferentiated pancreatic cancer cell line, were incubated without hormone (control) or with 0.1 microM EGF or somatostatin analogue RC-160 for 1 hr at 4 degrees C to phosphorylate the 60-kDa protein.
(4) Upon analysis of the morphologic characteristics of the protoscoleces derived from the cysts, the sizes of rostellar hooks from the material from the paca were found to be well within the ranges reported in previous studies.
(5) A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2).
(6) In vitro studies revealed that the relatively resistant cell line, WD PaCa (or well-differentiated pancreatic adenocarcinoma of the Syrian hamster), actually had higher ADR cellular levels than the sensitive cell line, PD PaCa (or poorly differentiated pancreatic adenocarcinoma of the Syrian hamster).
(7) 5,575, 1986]; one transcript predicts an amino acid sequence identical to that predicted by our MIA PaCa-2 cDNA clone; the other transcript predicts a similar protein containing a three amino acid residue insertion.
(8) In this investigation, the human pancreatic undifferentiated cell line, MIA PaCa-2, was compared with PANC-1 cells (a human ductal cell line previously characterized), isolated rat and human ducts, acinar cells, and nonpancreatic cell lines.
(9) Approximately 75% of the amino acids identified in both MIA PaCa CSF-1 and murine CSF-1 were found to be common to both.
(10) The established cell line (MIA PaCa-2) has a doubling time of 40 h. The cells are large with abundant cytoplasm, exhibit a high degree of aneuploidy and have a tendency to grow on top of other cells.
(11) With this assay, androgen receptors were detected in five fresh human pancreatic adenocarcinoma specimens (three male), two pancreatic cancer cell lines (Mia PaCa 2 and Ger), one xenograft tumor which responded to androgens, five specimens of normal adult pancreas (two male), and a pool of fetal pancreatic tissue.
(12) It is suggested that the antileishmanial action of PIHCA and other PACA nanoparticles results from the activation of respiratory burst in macrophages.
(13) Human cell lines resistant to L-asparaginase or albizziin were isolated by multistep selection of HT1080 fibrosarcoma and MIA PaCa-2 pancreatic carcinoma cells.
(14) Maximal response to CCK8 occurred at the 10(-9) M dose for each cell line: MIA PaCa-2, 40% (P less than 0.025); PANC-1, 85% (P less than 0.001); RWP-2, 68% (P less than 0.001) and CAPAN-2, 52% (P less than 0.001).
(15) Two human pancreatic adenocarcinoma cell lines (PANC 1 and MIA PACA 2) were examined for expression of growth factors that could potentially play a role either in growth regulation of the tumor cells, or in cells that comprise the stromal elements of tumors.
(16) The administration of etoposide prior to FP resulted in synergistic cytotoxicity in L1210, HCT-8, Mia PaCa, MCF-7, and T47-D cells while the reverse sequence resulted in additive or antagonistic cytotoxicity in L1210, HCT-8, and Mia PaCa cells.
(17) The production of plasminogen activator by Mia PaCa-2 cells is totally inhibited by actinomycin D and cycloheximide.
(18) Four of the patients with polycystic hydatid disease observed by us reported that they were aware of the presence of liver disease in the pacas hunted for food.
(19) MIA PaCa-2 and AsPC-1, and a gall bladder carcinoma cell line, G-415.
(20) Gel permeation chromatography of a mixture of the PACA and actinide elements have shown these substances to be strong chelating agents similar to EDTA or DTPA.
Rodent
Definition:
(v. t.) Gnawing; biting; corroding; (Med.) applied to a destructive variety of cancer or ulcer.
(v. t.) Gnawing.
(v. t.) Of or pertaining to the Rodentia.
(n.) One of the Rodentia.
Example Sentences:
(1) Intoxicating concentrations of ethanol also inhibit excitatory synaptic transmission mediated by N-methyl-D-aspartate receptors in hippocampal slices from adult rodents.
(2) This is the first clear example of activation of the K-ras gene by ethylating agents in a rodent lung tumor system.
(3) The relatively high incidence of nephroblastoma in the Nb rat using transplacentally administered ENU appears to represent a suitable basis for developing a rodent model of human nephroblastoma or Wilms' tumor.
(4) Male Sprague Dawley rats either trained (T, N = 9) for 11 wk on a rodent treadmill, remained sedentary, and were fed ad libitum (S, N = 8) or remained sedentary and were food restricted (pair fed, PF, N = 8) so that final body weights were similar to T. After training, T had significantly higher red gastrocnemius muscle citrate synthase activity compared with S and PF.
(5) This model of protective immunity in a Brugia-susceptible small rodent may provide a useful system for identification of molecularly defined filarial-protective immunogens.
(6) The receptor pattern observed in tumors does not support the hypothesis previously raised in the case of chemically induced colonic tumors in rodents.
(7) It is concluded that these rodent studies do not implicate any specific inhalational anesthetic agent in fetal toxicity, and that the effects of additional factors, such as stress, must be considered.
(8) In the course of routinely performed subchronic toxicity studies with laboratory rodents, functional neurotoxicity, i.e.
(9) Particularly striking is the distribution of CpG dinucleotides within human and rodent APRT genes.
(10) There was less of an increase following a blood meal infected with the rodent malaria parasite, Plasmodium berghei.
(11) An analysis of 54 protein sequences from humans and rodents (mice or rats), with the chicken as an outgroup, indicates that, from the common ancestor of primates and rodents, 35 of the proteins have evolved faster in the lineage to mouse or rat (rodent lineage) whereas only 12 proteins have evolved faster in the lineage to humans (human lineage).
(12) The differences in immunoreactivity between rodent and human amyloid plaques are consistent with other findings showing that cellular genes, not infectious purified prions, encode PrP.
(13) These products, as well as several synthetic intermediates, were evaluated for antifilarial activity against Molinema dessetae either in vivo in its natural host, the rodent Proechimys oris, or in vitro by a new test using cultures of the infective larvae.
(14) An increased neuronal activity was obtained by exercising the rats in a commercial rodent treadmill a couple of hours per day for 14 days.
(15) In a series of experiments we found that 1) growth rates of hamsters offered the Lyric diet alone or in conjunction with the standard rodent diet exceeded those of hamsters offered only the standard rodent diet.
(16) A model system of exfoliated normal human cervicovaginal squamous cells, exfoliated rodent tumor cells, and acellular, viscous, mucuslike material was used to investigate cell deposition on smear preparations made with three different instruments: plastic spatulas, wooden spatulas, and brush-tipped collectors.
(17) With repeated administrations, rodents become increasingly sensitive to the stimulant properties of amphetamine, a phenomenon termed sensitization.
(18) Although the overall rate of thymidine incorporation was lower than that for rodent cells, human hepatocytes were sensitive to lower concentrations of these growth factors, and the degree of stimulation was similar.
(19) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(20) Since PEG-1000 treatment of HPRT- Chinese hamster cells in the absence of human cells yielded no HPRT+ cells, it is concluded that the element responsible for the restoration of rodent HPRT was contributed by the human cells and not by the agent employed to promote fusion.