(1) To study the role of the PENK gene in opioid related processes, an antisense sequence of PENK gene was subcloned into pSVL SV 40 late promoter expression vector and stably transfected into NG 108-15 cells, which contain opioid receptors.
(2) From steady-state kinetics half-life estimates of 9.6 h for PPenk mRNA and 14.7 h for Penk peptide were obtained.
(3) The Penk Combat Exposure scale did not separate the groups.
(4) "I was half expecting to see him on Songs of Praise," Penk added.
(5) Clinical observations and empirical evidence suggest that, among Vietnam combat veterans, Blacks are more maladjusted than Whites (e.g., Parsons, 1985; Penk et al., 1985).
(6) Penk, who now owns the Oldham-based local radio station 96.2 Revolution, said he was "appalled" at the "sheer scale of this unfair cross-promotion".
(7) "In these hard times it is difficult enough for the large, quasi-national commercial radio brands to compete with such unfair 'free' publicity," said Penk.
(8) The Penk Combat Intensity scale, which was correlated highly with the Keane scale, differentiated the PTSD-positive patients from both the normals and the PTSD-negative patients, but with less differentiating power (omega 2'S = .07 and .08).
(9) Facebook Twitter Pinterest The former Capital and Virgin Radio DJ Steve Penk has written to the BBC Trust to complain about the "excessive" and "gratuitous" cross-promotion of Chris Evans's new Radio 2 breakfast show on television.
(10) An increase in PENK mRNA levels has been also observed in cultures treated with 8-Br-cAMP, phorbol 12-myristate-13-acetate (TPA), or dexamethasone.
(11) Thus, activation of Penk gene expression upon neurotransmitter challenge is suggested to be due to an enhanced transcriptional activity of the gene mediated by de novo synthesized protein (-like) factors.
(12) We suggest that both the increased PENK message and the unchanged levels of free Met-enkephalin may be the result of compensatory mechanisms induced by translational inhibition by antisense, although the underlying processes remain to be determined.
(13) Penk was also critical of what he called the "placement" of Evans on BBC TV shows including Friday Night with Jonathan Ross, the One Show and the Andrew Marr Show.
(14) Unilateral adrenal denervation resulted in a rapid decrease in PPenk mRNA levels of 54% after 2 days, and by 11 days 90% of Penk mRNA had disappeared.
(15) Penk claimed the Evans trail broke the BBC Trust's own policy on cross-promotion.
(16) However, incubation of the cultures with the opioid agonist etorphine or the antagonist naltrexone did not alter PENK gene expression, suggesting that there is not feedback control of opioids on PENK biosynthesis in these cells.
(17) In this study we identified the potential sites of synthesis by localizing the mRNA coding for PENK in the rat pituitary gland using in situ hybridization histochemistry.
(18) Depolarization with potassium chloride (KCl) or veratridine increases the expression of PENK mRNA in a time-dependent fashion, with a maximal increase of sixfold.
(19) The proenkephalin A (PENK) gene codes for several opioid peptides, including Met-enkephalin, an endogenous ligand of opioid receptors.
(20) After an initial lag phase (with no major alterations) Penk mRNA increased markedly between 6 and 12 h followed by a slower, steady increase up to 48 h. The nicotinic receptor antagonist tubocurarine (4 x 10(-7) M) and the Ca2+ channel blocker D600 (10(-5) M) prevent the subsequent rise of Penk mRNA levels after challenge with nicotine, when given within the lag phase (0-6 h), suggesting the need of continuous receptor occupation and Ca2+ entry for induction of gene expression.
Perk
Definition:
(v. t.) To make trim or smart; to straighten up; to erect; to make a jaunty or saucy display of; as, to perk the ears; to perk up one's head.
(v. i.) To exalt one's self; to bear one's self loftily.
(a.) Smart; trim; spruce; jaunty; vain.
(v. i.) To peer; to look inquisitively.
Example Sentences:
(1) Furthermore, between matches, players can test all their new perks and weapons via an easily accessible firing range – instead of having to try them out in a match.
(2) He had earlier seen little support for his push to cut EU pay and perks.
(3) A number of companies, including B&Q, Tesco and Morrisons have raised basic pay only to cut perks and premium payments for weekend, holiday or late working.
(4) The company previously attracted heavy criticism with plans to eliminate the morning perk of free tea and toast handed out to staff across 230 stores.
(5) We’re not asking for perks, just for recognition on how hard we really do work, and not taking a pay cut is part of this.
(6) July 8, 2014 Richard Perks (@RichardP_Mintel) Has M&S been switching space from furniture to clothing to make the clothing figures look better?
(7) However, BA believes it has tempered willingness to strike by the threat to withdraw travel perks and by running a robust contingency schedule during 22 days for strikes during March, May and June.
(8) VIPs, VVIPs or even VVVIPs – almost all government officials – can receive perks ranging from free housing in listed villas with staff paid by the government, bodyguards who act as personal assistants, free flights, unobstructed passage through airports or train stations as well as a significant degree of de facto legal impunity.
(9) Yet, the current proposal appears aimed at ludicrously legislating the economic cycle and creating ever higher fixed salaries and perks for those leading the largest banks.
(10) BA has offered to reinstate staff travel perks but without the seniority clauses that give long-serving cabin crew priority over junior colleagues.
(11) The authors previously reported morning-to-evening changes in ophthalmic measurements at 3 months and at 1-year after radial keratotomy in a self-selected group of patients in the Prospective Evaluation of Radial Keratotomy (PERK) study.
(12) They did, however, let the dog diner sit on the banquette to eat his lunch – quite possibly a first – and swiftly perked up when the owner came out to greet him.
(13) There are 30 new weapons, including a new class of marksman rifles; Perks now have a points system, allowing you to buy several weaker options or opt for one or two really meaty specials.
(14) She apparently thought she could “conscientiously object” and keep the perks of the job she conscientiously objects to performing at the same time.
(15) Always a good cook, she had a Damascene moment one day when, looking for a way to perk up a slightly flat pasta dish, she gave it a squeeze of lemon.
(16) Should pensioners forfeit perks or Labour impose a higher corporation tax?
(17) More highly myopic patients in the PERK population (-4.50 to -8.00 diopters [D]) demonstrated corneas that are 0.08 to 0.10 mm steeper than the less myopic population (-2.00 to -3.12 D).
(18) A proposed deal was reached in May, but one which included sanctions against crew who had been on strike and deprived low-paid staff of travel perks.
(19) These days the Radiohead frontman tries to calm himself down – and perk up his spirits – with yoga and meditation.
(20) The business's values, which include "putting the happiness of partners at the centre of everything we do", have not always been fashionable but the formula of rewarding staff – on top of the bonus staff will receive discounts and perks ranging from subsidised holidays to sailing clubs and theatre outings worth £120m this year – went from strength to strength during the recession.