(n.) The soft spongy substance in the center of the stems of many plants and trees, especially those of the dicotyledonous or exogenous classes. It consists of cellular tissue.
(n.) The spongy interior substance of a feather.
(n.) The spinal cord; the marrow.
(n.) Hence: The which contains the strength of life; the vital or essential part; concentrated force; vigor; strength; importance; as, the speech lacked pith.
(v. t.) To destroy the central nervous system of (an animal, as a frog), as by passing a stout wire or needle up and down the vertebral canal.
Example Sentences:
(1) Finally, fosinopril had no effect on the pressor or chronotropic effects of norepinephrine (NE) or 1,1-dimethyl-4-phenylpiperinium (DMPP) or electrical stimulation of the sympathetic ganglia of pithed rats.
(2) Relatively weaker GUS activity was also detected in pith parenchyma.
(3) Both d- and l-amphetamine were also compared for their pressor and tachycardic activity in pithed rats.
(4) Intravenous administration of T-2 to pithed rats did not alter blood pressure or heart rate at a time when, in conscious rats, both blood pressure and heart rate were increased.
(5) Monoiodo-Ang II was found to be a potent, full agonist in in vivo bioassays and a more potent (2.5-fold) pressor agent than the native hormone Ang II in the pithed rat.
(6) APP 201-533 [3-amino-6-methyl-5-phenyl-2(1H)-pyridinone] was investigated in vivo in anesthetized and unanesthetized dogs and pithed open-chest cats and in vitro in guinea pig atria and papillary muscles, skinned muscle fibers from pig hearts, and rat myocardium.
(7) The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of the cardioaccelerator (10 V; 1 ms; 0.5, 1, 3, 6 Hz) and vagus (10 V; 1 ms; 3, 6, 9 Hz) nerves respectively.
(8) Pith cells can shift from the C- to the C+ state by a process known as habituation.
(9) The pressor actions of ET3 and arginine vasopressin (AVP) were compared with one another in pithed rats in the presence of the calcium channel activator BAY K 8644 or the calcium channel antagonist nifedipine i.a.
(10) Both human endothelin 1 (ET1) and rat endothelin 3 (ET3) produced dose-dependent pressor effects in the pithed rat.
(11) Viprostol did not antagonize the tachycardia induced by stimulation of the discrete segments at C7-T1 (cardio-accelerator) of the spinal cord in pithed SHR, suggesting that viprostol did not activate the presynaptic alpha-adrenoceptors.
(12) In pithed rats, the vasopressor response to dihydroergotoxine was reduced competitively by yohimbine, and non-competitively by nifedipine, but not by prazosin or methysergide, showing that the vasoconstriction is mediated by alpha 2-adrenoceptors.
(13) The antagonistic effects of a new inositol phosphate derivative, D-myoinositol-1,2,6-trisphosphate (PP56), on pressor responses to preganglionic sympathetic nerve stimulation and exogenously administered phenylephrine or neuropeptide Y (NPY) were investigated in vivo in the pithed rat.
(14) We conclude that in contrast to the increase in diastolic pressure elicited by B-HT 920, calcium channels are not involved in the cirazoline-induced pressor responses in the pithed cat.
(15) Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat.
(16) Habituated cells derived from inducible pith cells give rise to normal plants whose leaf and pith tissues require cytokinin for growth in culture.
(17) The endovenous perfusion of the splenic material in acidified and alkalinized forms caused significant increases of the mean blood pressure in normal, vagotomized and pithed rats, showing that, in contradiction to previous reports, changes in pH did not affect its hypertensive activity.
(18) The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v.
(19) In pithed rats, only pindolol produced a definite fall of blood pressure.
(20) The bradycardia was reduced but not blocked by pre-treatment with guanethidine, yohimbine, propranolol or pithing.
Pithy
Definition:
(superl.) Consisting wholly, or in part, of pith; abounding in pith; as, a pithy stem; a pithy fruit.
(superl.) Having nervous energy; forceful; cogent.
Example Sentences:
(1) And while Altmejd presents sexual scenes of cartoonish horror and disgust, Lucas's art has embraced lavatorial humour, abjection, self-denigration, the pithy sculptural one-liner and the obscene gesture.
(2) This headline is a closely packed, multifaceted, pithy, rousing, basically perfect example of how strikes are presented in the tabloids, and have been for years.
(3) In fact, her pithy insults are deployed so regularly that colleagues on the spending watchdog have come up with the idea of playing “Margaret Hodge bingo”, scoring points when one of her putdowns pops out.
(4) The reshuffle had inspired some pithy one-liners and the PM was determined to deploy them all.
(5) Someone who bought tickets for a tennis event at the O2 sent me this pithy tweet: “4 tickets.
(6) There are plenty of 30-page documents and pithy slogans – but, as far as I can discover, nothing in between.
(7) It was a pithy line that feeds into the schtick about a bloated Brussels filled with born bureaucrats.
(8) The hawkish senator also defined his foreign policy: “A clenched fist and an open hand, you choose.” But the extent to which such pithy quips will help bolster Graham’s campaign – the senator is currently polling at 0.5% – remains questionable.
(9) But he has left Labour vulnerable over Brexit because the policy is so nuanced it cannot easily be boiled down to a pithy remark .
(10) Shortly after the YouTube sensation that was Jeremy Paxman's October interview with Russell Brand , Paxman wrote a pithy column about his disillusion with Westminster politics.
(11) Johnson, whose pithy interventions have caused embarrassment for all the major parties since the election campaign kicked off, opened the debate by stressing the gulf between the two major parties’ tax and spending plans.
(12) Sated by three years of Special One pyrotechnics, the British press might be ready to be charmed by Ramos' brand of quietly pithy humour.
(13) Obama: While the president generally struggled to get his "zingers" across, over-larding them with too much detail, he did get in a pithy dig about Romney's vague budget proposals which he claimed didn't add up.
(14) Jimmy Fallon, the host of the 2017 Golden Globes, has made a career of creating pithy viral moments that transcend television and resonate on the internet, but at this year’s ceremony the host was outdone by a bizarre recurring slip-up.
(15) In the months since their formation, the eight members of Pussy Riot have perfected their own form of protest: their songs are pithy, angry missives, largely directed at Putin, and they remain beguilingly anonymous – the band wear neon balaclavas to conceal their identities and perform flash gigs in unexpected places: on public transport, for example, and, once, on a prison roof.
(16) Instead, finance ministers signed up to a pithy list of bullet points, pledging to unleash all the policy weapons at their disposal against the crisis.
(17) The club was the brainchild of New Jersey shoe salesman Barney Josephson: a pithy antidote to the snooty, often racist elitism of other New York nightspots.
(18) But threnodies are not an argument, and memories are definitely not facts (Hobsbawm's pithy condemnation of oral history, delivered at a conference where I was due to speak, was terrifying).
(19) From a leader not known for her trenchant words or pithy sound bites her strong stance of the past few days has come as a surprise.
(20) You might expect he’d specialise in pithy one-liners, but in fact Delaney spins longer yarns onstage, all powered by a spirit of relentless cynicism.