(n.) The soft spongy substance in the center of the stems of many plants and trees, especially those of the dicotyledonous or exogenous classes. It consists of cellular tissue.
(n.) The spongy interior substance of a feather.
(n.) The spinal cord; the marrow.
(n.) Hence: The which contains the strength of life; the vital or essential part; concentrated force; vigor; strength; importance; as, the speech lacked pith.
(v. t.) To destroy the central nervous system of (an animal, as a frog), as by passing a stout wire or needle up and down the vertebral canal.
Example Sentences:
(1) Finally, fosinopril had no effect on the pressor or chronotropic effects of norepinephrine (NE) or 1,1-dimethyl-4-phenylpiperinium (DMPP) or electrical stimulation of the sympathetic ganglia of pithed rats.
(2) Relatively weaker GUS activity was also detected in pith parenchyma.
(3) Both d- and l-amphetamine were also compared for their pressor and tachycardic activity in pithed rats.
(4) Intravenous administration of T-2 to pithed rats did not alter blood pressure or heart rate at a time when, in conscious rats, both blood pressure and heart rate were increased.
(5) Monoiodo-Ang II was found to be a potent, full agonist in in vivo bioassays and a more potent (2.5-fold) pressor agent than the native hormone Ang II in the pithed rat.
(6) APP 201-533 [3-amino-6-methyl-5-phenyl-2(1H)-pyridinone] was investigated in vivo in anesthetized and unanesthetized dogs and pithed open-chest cats and in vitro in guinea pig atria and papillary muscles, skinned muscle fibers from pig hearts, and rat myocardium.
(7) The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of the cardioaccelerator (10 V; 1 ms; 0.5, 1, 3, 6 Hz) and vagus (10 V; 1 ms; 3, 6, 9 Hz) nerves respectively.
(8) Pith cells can shift from the C- to the C+ state by a process known as habituation.
(9) The pressor actions of ET3 and arginine vasopressin (AVP) were compared with one another in pithed rats in the presence of the calcium channel activator BAY K 8644 or the calcium channel antagonist nifedipine i.a.
(10) Both human endothelin 1 (ET1) and rat endothelin 3 (ET3) produced dose-dependent pressor effects in the pithed rat.
(11) Viprostol did not antagonize the tachycardia induced by stimulation of the discrete segments at C7-T1 (cardio-accelerator) of the spinal cord in pithed SHR, suggesting that viprostol did not activate the presynaptic alpha-adrenoceptors.
(12) In pithed rats, the vasopressor response to dihydroergotoxine was reduced competitively by yohimbine, and non-competitively by nifedipine, but not by prazosin or methysergide, showing that the vasoconstriction is mediated by alpha 2-adrenoceptors.
(13) The antagonistic effects of a new inositol phosphate derivative, D-myoinositol-1,2,6-trisphosphate (PP56), on pressor responses to preganglionic sympathetic nerve stimulation and exogenously administered phenylephrine or neuropeptide Y (NPY) were investigated in vivo in the pithed rat.
(14) We conclude that in contrast to the increase in diastolic pressure elicited by B-HT 920, calcium channels are not involved in the cirazoline-induced pressor responses in the pithed cat.
(15) Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat.
(16) Habituated cells derived from inducible pith cells give rise to normal plants whose leaf and pith tissues require cytokinin for growth in culture.
(17) The endovenous perfusion of the splenic material in acidified and alkalinized forms caused significant increases of the mean blood pressure in normal, vagotomized and pithed rats, showing that, in contradiction to previous reports, changes in pH did not affect its hypertensive activity.
(18) The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v.
(19) In pithed rats, only pindolol produced a definite fall of blood pressure.
(20) The bradycardia was reduced but not blocked by pre-treatment with guanethidine, yohimbine, propranolol or pithing.
Pity
Definition:
(n.) Piety.
(n.) A feeling for the sufferings or distresses of another or others; sympathy with the grief or misery of another; compassion; fellow-feeling; commiseration.
(n.) A reason or cause of pity, grief, or regret; a thing to be regretted.
(v. t.) To feel pity or compassion for; to have sympathy with; to compassionate; to commiserate; to have tender feelings toward (any one), awakened by a knowledge of suffering.
(v. t.) To move to pity; -- used impersonally.
(v. i.) To be compassionate; to show pity.
Example Sentences:
(1) The voters don’t do gratitude, self-pitying politicians are wont to moan.
(2) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(3) "); hopeless self-pity ("Nobody said anything to me about Billy ... all day long") and rage ("You want to put a bench in the park in Billy's name?
(4) Indeed, mainstream economics is a pitifully thin distillation of historical wisdom on the topics that it addresses.
(5) Would you really feel any pity if one of those dots stopped moving forever?” It is there to remind him that the dots are worth fighting for.
(6) Last year, Amnesty International described the world’s response as “pitiful” and earlier this week, the UN special rapporteur on the human rights of migrants called on the EU to deliver a proper resettlement programme.
(7) April's family had to endure the "spectacle of your hypocritical sympathy for their loss and of your tears", the judge told Bridger, saying any tears were motivated purely by self-pity.
(8) And this is the mainspring of so many of his stories, novellas, and his one novel, Beware of Pity : the clash between propriety and desire.
(9) It’s actually a pity that there’s now a break because I wanted to continue playing games,” said the Italian.
(10) In his final fight, against the journeyman boxer Kevin McBride, he was a pitiful figure - slumped in a corner, legs splayed, unable or unwilling to stand himself up.
(11) Other negative emotions – self-pity, guilt, apathy, pessimism, narcissism – make it a deeply unattractive illness to be around, one that requires unusual levels of understanding and tolerance from family and friends.
(12) He said it was a “pity” that the UK prime minister “wasn’t able to express the British position at the press conference with Donald Trump standing next to her”.
(13) As the turbulent commercial radio sector enters another new phase, Park wants to sweep away the thinking that has left too many of his colleagues wallowing in self-pity, and turn his fire on a familiar target.
(14) Broadly defined, this sort of behaviour involves procrastination, stubbornness, resentment, sullenness, obstructionism, self-pity and a tendency to create chaotic situations.
(15) It is a pity we did not take our chances,” the Ukraine coach, Mykhailo Fomenko, said.
(16) "This depressing morning has now got me questioning my pitiful existence," sobs James Dodge.
(17) Foreign dignitaries were invited to attend for the first time and it is a pity that from Europe only Javier Solana chose to take the offer up.
(18) Men convicted of rape are often pitied in the media and, like Evans, quickly vault back to positions of fame .
(19) But after the strange denials that this old, sick man is dying I want to talk not with pity but of his power.
(20) Staff here dread the welfare reform bill, waiting for debts, arrears, evictions and pitiful hardship to wash up on their doorstep.