(n.) The soft spongy substance in the center of the stems of many plants and trees, especially those of the dicotyledonous or exogenous classes. It consists of cellular tissue.
(n.) The spongy interior substance of a feather.
(n.) The spinal cord; the marrow.
(n.) Hence: The which contains the strength of life; the vital or essential part; concentrated force; vigor; strength; importance; as, the speech lacked pith.
(v. t.) To destroy the central nervous system of (an animal, as a frog), as by passing a stout wire or needle up and down the vertebral canal.
Example Sentences:
(1) Finally, fosinopril had no effect on the pressor or chronotropic effects of norepinephrine (NE) or 1,1-dimethyl-4-phenylpiperinium (DMPP) or electrical stimulation of the sympathetic ganglia of pithed rats.
(2) Relatively weaker GUS activity was also detected in pith parenchyma.
(3) Both d- and l-amphetamine were also compared for their pressor and tachycardic activity in pithed rats.
(4) Intravenous administration of T-2 to pithed rats did not alter blood pressure or heart rate at a time when, in conscious rats, both blood pressure and heart rate were increased.
(5) Monoiodo-Ang II was found to be a potent, full agonist in in vivo bioassays and a more potent (2.5-fold) pressor agent than the native hormone Ang II in the pithed rat.
(6) APP 201-533 [3-amino-6-methyl-5-phenyl-2(1H)-pyridinone] was investigated in vivo in anesthetized and unanesthetized dogs and pithed open-chest cats and in vitro in guinea pig atria and papillary muscles, skinned muscle fibers from pig hearts, and rat myocardium.
(7) The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of the cardioaccelerator (10 V; 1 ms; 0.5, 1, 3, 6 Hz) and vagus (10 V; 1 ms; 3, 6, 9 Hz) nerves respectively.
(8) Pith cells can shift from the C- to the C+ state by a process known as habituation.
(9) The pressor actions of ET3 and arginine vasopressin (AVP) were compared with one another in pithed rats in the presence of the calcium channel activator BAY K 8644 or the calcium channel antagonist nifedipine i.a.
(10) Both human endothelin 1 (ET1) and rat endothelin 3 (ET3) produced dose-dependent pressor effects in the pithed rat.
(11) Viprostol did not antagonize the tachycardia induced by stimulation of the discrete segments at C7-T1 (cardio-accelerator) of the spinal cord in pithed SHR, suggesting that viprostol did not activate the presynaptic alpha-adrenoceptors.
(12) In pithed rats, the vasopressor response to dihydroergotoxine was reduced competitively by yohimbine, and non-competitively by nifedipine, but not by prazosin or methysergide, showing that the vasoconstriction is mediated by alpha 2-adrenoceptors.
(13) The antagonistic effects of a new inositol phosphate derivative, D-myoinositol-1,2,6-trisphosphate (PP56), on pressor responses to preganglionic sympathetic nerve stimulation and exogenously administered phenylephrine or neuropeptide Y (NPY) were investigated in vivo in the pithed rat.
(14) We conclude that in contrast to the increase in diastolic pressure elicited by B-HT 920, calcium channels are not involved in the cirazoline-induced pressor responses in the pithed cat.
(15) Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat.
(16) Habituated cells derived from inducible pith cells give rise to normal plants whose leaf and pith tissues require cytokinin for growth in culture.
(17) The endovenous perfusion of the splenic material in acidified and alkalinized forms caused significant increases of the mean blood pressure in normal, vagotomized and pithed rats, showing that, in contradiction to previous reports, changes in pH did not affect its hypertensive activity.
(18) The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v.
(19) In pithed rats, only pindolol produced a definite fall of blood pressure.
(20) The bradycardia was reduced but not blocked by pre-treatment with guanethidine, yohimbine, propranolol or pithing.
Supreme
Definition:
(a.) Highest in authority; holding the highest place in authority, government, or power.
(a.) Highest; greatest; most excellent or most extreme; utmost; greatist possible (sometimes in a bad sense); as, supreme love; supreme glory; supreme magnanimity; supreme folly.
(a.) Situated at the highest part or point.
Example Sentences:
(1) Earlier this week the supreme court in London ruled against a mother and daughter from Northern Ireland who had wanted to establish the right to have a free abortion in an English NHS hospital.
(2) Can somebody who is not a billionaire, who stands for working families, actually win an election into which billionaires are pouring millions of dollars?” Naming prominent and controversial rightwing donors, he said: “It is not just Hillary, it is the Koch brothers, it is Sheldon Adelson.” Stephanopoulos seized the moment, asking: “Are you lumping her in with them?” Choosing to refer to the 2010 supreme court decision that removed limits on corporate political donations, rather than address the question directly, Sanders replied: “What I am saying is that I get very frightened about the future of American democracy when this becomes a battle between billionaires.
(3) To organise society as an individualistic war of one against another was barbaric, while the other models, slavishly following the rules of one religion or one supreme leader, denied freedom.
(4) However, the law minister indicated he would allow the supreme court to approve a draft of the letter.
(5) He can appoint Garland to the supreme court, and even push through the other 58 federal judicial nominees that are pending.
(6) America's same-sex couples, and the politicians who have barred gay marriage in 30 states, are looking to the supreme court to hand down a definitive judgment on where the constitution stands on an issue its framers are unlikely to have imagined would ever be considered.
(7) Part II reviews Supreme Court cases and state law regarding abortion counseling, critizing both the Court's narrow view of counseling and the states' failure to use the legislative process to create laws which benefit maternal health.
(8) Tension heightened last week after Davis continued to refuse licenses to couples; on Friday, she filed a request to the supreme court to stay the lower court’s decision.
(9) Egypt has been without a sitting lower house of parliament since summer 2012, when it was dissolved by the country's supreme court .
(10) Same-sex marriage: supreme court's swing votes hang in the balance – live Read more The court heard legal arguments for two and a half hours, in a landmark challenge to state bans on same-sex marriage that is expected to yield a decision in June.
(11) In the Proposition 8 legal action, the supreme court could decide: • There is a constitutional right, under the equal protection clauses, for gay couples to wed, in which case the laws in 30 states prohibiting same-sex marriages are overturned.
(12) The difficulty has been increased with the recent Supreme Court decision which it ruled the Alien Tort Claims Act does not apply outside of the country and dismissed a case against Royal Dutch Shell.
(13) The current president of the supreme court, Lord Phillips, who steps down at the end of September, welcomed his successor, praising his "wealth of judicial experience" and "ability to lead a collegiate court".
(14) The advocates had attempted to get a decision by filing lawsuits directly with the supreme court rather than through an appeal of a lower court decision.
(15) Though there will be an open competition, the job is expected to go to Lord Dyson, who will step down from the supreme court to become master of the rolls.
(16) Her lawyer, Winston Cochran, said he would mount last-minute appeals and potentially take the case to the supreme court.
(17) Last September, propelled by the success of the Irish referendum and the US supreme court decision, the idea that Australian parliamentarians should, as a matter of conscience, reconsider marriage equality was gathering powerful force.
(18) They also said there was no clear common law right to vote in the UK.The supreme court will publish a full ruling later.
(19) Critics of Rouhani’s policy of rapprochement with the international community inside Iran can turn to the supreme leader and say there wasn’t really much need for that softer tone because now we have more bargaining chips in our hands.
(20) Nonetheless, the NSA persuaded Erwin Griswold, the former dean of Harvard law school, the then solicitor general of the United States, to knowingly lie to the United States supreme court that it was still a secret.