(1) Both types of microsphere overcame the initial rapid release of cDDP (burst effect), and PLAGA-coated albumin microspheres also showed a lag phase of approximately 30 min before cDDP release began.
(2) PLAGA-coated albumin microspheres released most of their payload through diffusion, and the coating eventually cracked after 7 days' incubation in saline supplemented with 0.1% Tween at 37 degrees C, enabling the release of any cDDP remaining.
(3) Effects of platinum, pre-released from PLAGA-coated albumin microspheres on the in vitro growth of L1210 cells were comparable with those of standard formulations (dissolved) of cDDP.
(4) Liver-to-kidney platinum level ratios were 28 times higher after 4 h and 19 times higher after 24 h with PLAGA-cDDP microspheres than with free cDDP.
(5) Protein-linked 1-hydroxyethylphosphonate was previously described as the dead-end product after reaction of the analogue with the intermediary acetyl-enzyme form of the catalytic cycle [W. Plaga et al.
(6) PLAGA-cDDP microspheres may, therefore, be a useful and effective addition to current techniques of loco-regional chemotherapy for disseminated hepatic tumors.
(7) These findings indicate a sparing effect on normal tissues when cDDP is targeted to the liver by formulation in PLAGA.
(8) These studies show that formulation of cDDP in PLAGA-based microspheres prevents the rapid burst effect of cDDP seen in previous preparations and offers an improved system of administration for hepatic artery infusion or adjuvant therapy, enabling better clinical handling and the promise of a higher ratio of tumour tissue to normal tissue.
(9) We used a poly-lactide-co-glycolide polymer (PLAGA 50:50) to formulate cisplatin (cDDP) into microspheres designed for intravascular administration.
(10) In a CC531 colon carcinoma liver micrometastases model, cytotoxicity of microsphere-released cDDP was confirmed in vivo by equal inhibition of tumor growth by PLAGA-cDDP and free cDDP over a period of 26 days.
(11) Kidney platinum levels were 7 times lower when PLAGA-cDDP was used.
(12) PLAGA-coated albumin microspheres and microspheres consisting of PLAGA only.
(13) Material released from non-drug-loaded PLAGA microspheres had no effect on L1210 cell growth, suggesting the absence of cytotoxic compounds in the matrix.
(14) Liver-to-blood platinum ratios at these times were 38 times and 36 times higher using PLAGA-cDDP.
Plaza
Definition:
(n.) A public square in a city or town.
Example Sentences:
(1) The following year, JFK was killed in Dealey Plaza, becoming the lost father to a grieving nation.
(2) The 1,127 killed at Rana Plaza in the Dhaka suburb of Savar are among at least 1,800 Bangladesh garment-industry workers killed in fires or building collapses since 2005.
(3) "Anniversaries should be to celebrate good things, not something like Rana Plaza."
(4) After years of foot dragging, three global agreements have emerged in an attempt to improve matters since the Rana Plaza tragedy in April.
(5) WEEKEND GETAWAY Côte d'Azur TO CELEBRATE THAT DEAL The spring tasting menu at Alain Ducasse's restaurant at the Plaza Athénée will set you back €360 ($520).
(6) Last year retailers sourcing garments from Bangladesh faced similar calls to quit the country following the collapse of the Rana Plaza building.
(7) Women also make up the majority of the 5,000 people – disabled survivors and families of victims – who are still owed compensation by the brands that used Rana Plaza.
(8) This week, another UK event will focus on those left in poverty by Rana Plaza.
(9) A day after making a personal appeal to the US and Cuban leaders to end their half-century of estrangement , Francis issued his plea to Colombia’s warring factions from Revolution Plaza at the end of his Sunday mass.
(10) Clothing retailers River Island and Matalan have signed up to a factory safety deal in Bangladesh after pressure from campaigners in the wake of the Rana Plaza factory collapse, which killed more than 1,000 factory workers.
(11) Many debate where the blame lies for tragedies such as Rana Plaza, and argue over who has the responsibility to prevent them in the future.
(12) Women whose children and grandchildren had disappeared organized themselves as Grandmothers of Plaza de Mayo to search for their missing loved ones.
(13) At about 10.30pm last night we received multiple calls about shots being fired from inside the plaza,” police chief John Mina told reporters.
(14) This is why it’s so important to name those responsible and not leave it as if this is an a-historic massacre.” Zedconte, 26, works as a consultant in Guadalajara Protest reach Plaza de la Liberacion in Guadalajara Protestors sit around an improvised podium where student victims and missing names where remembered.
(15) Facebook Twitter Pinterest Shahorbanu, whose son Siddique was killed in the Rana Plaza collapse.
(16) On Saturday afternoons there is outdoor dancing at nearby Plaza de Danzón.
(17) The independent Plaza Art Cinema is a favourite of Luc and Jean-Pierre Dardenne.
(18) She said Trump made advances on her, including groping her under the table during a dinner the following night at the Plaza Hotel.
(19) Two years after Rana Plaza, have conditions approved in Bangladesh’s factories?
(20) Prior to Rana Plaza there had already been a string of disasters in Bangladesh’s garment industry, culminating in the Tazreen factory fire that killed 112 people six months earlier.