(1) Both types of microsphere overcame the initial rapid release of cDDP (burst effect), and PLAGA-coated albumin microspheres also showed a lag phase of approximately 30 min before cDDP release began.
(2) PLAGA-coated albumin microspheres released most of their payload through diffusion, and the coating eventually cracked after 7 days' incubation in saline supplemented with 0.1% Tween at 37 degrees C, enabling the release of any cDDP remaining.
(3) Effects of platinum, pre-released from PLAGA-coated albumin microspheres on the in vitro growth of L1210 cells were comparable with those of standard formulations (dissolved) of cDDP.
(4) Liver-to-kidney platinum level ratios were 28 times higher after 4 h and 19 times higher after 24 h with PLAGA-cDDP microspheres than with free cDDP.
(5) Protein-linked 1-hydroxyethylphosphonate was previously described as the dead-end product after reaction of the analogue with the intermediary acetyl-enzyme form of the catalytic cycle [W. Plaga et al.
(6) PLAGA-cDDP microspheres may, therefore, be a useful and effective addition to current techniques of loco-regional chemotherapy for disseminated hepatic tumors.
(7) These findings indicate a sparing effect on normal tissues when cDDP is targeted to the liver by formulation in PLAGA.
(8) These studies show that formulation of cDDP in PLAGA-based microspheres prevents the rapid burst effect of cDDP seen in previous preparations and offers an improved system of administration for hepatic artery infusion or adjuvant therapy, enabling better clinical handling and the promise of a higher ratio of tumour tissue to normal tissue.
(9) We used a poly-lactide-co-glycolide polymer (PLAGA 50:50) to formulate cisplatin (cDDP) into microspheres designed for intravascular administration.
(10) In a CC531 colon carcinoma liver micrometastases model, cytotoxicity of microsphere-released cDDP was confirmed in vivo by equal inhibition of tumor growth by PLAGA-cDDP and free cDDP over a period of 26 days.
(11) Kidney platinum levels were 7 times lower when PLAGA-cDDP was used.
(12) PLAGA-coated albumin microspheres and microspheres consisting of PLAGA only.
(13) Material released from non-drug-loaded PLAGA microspheres had no effect on L1210 cell growth, suggesting the absence of cytotoxic compounds in the matrix.
(14) Liver-to-blood platinum ratios at these times were 38 times and 36 times higher using PLAGA-cDDP.
Stripe
Definition:
(n.) A line, or long, narrow division of anything of a different color or structure from the ground; hence, any linear variation of color or structure; as, a stripe, or streak, of red on a green ground; a raised stripe.
(n.) A pattern produced by arranging the warp threads in sets of alternating colors, or in sets presenting some other contrast of appearance.
(n.) A strip, or long, narrow piece attached to something of a different color; as, a red or blue stripe sewed upon a garment.
(n.) A stroke or blow made with a whip, rod, scourge, or the like, such as usually leaves a mark.
(n.) A long, narrow discoloration of the skin made by the blow of a lash, rod, or the like.
(n.) Color indicating a party or faction; hence, distinguishing characteristic; sign; likeness; sort; as, persons of the same political stripe.
(n.) The chevron on the coat of a noncommissioned officer.
(v. t.) To make stripes upon; to form with lines of different colors or textures; to variegate with stripes.
(v. t.) To strike; to lash.
Example Sentences:
(1) Platinum deer mice are conspicuously pale, with light ears and tail stripe.
(2) And of course, as the articles are shared far and wide across the apparently much-hated web, they become gospel to those who read them and unfortunately become quasi-religious texts to musicians of all stripes who blame the internet for everything that is wrong with their careers.
(3) The striped expression of the Drosophila segmentation gene fushi tarazu in alternate parasegments of the early embryo is controlled by the 740 bp zebra element.
(4) Mutant plants are characterized by reduced height, defective yellow striping on leaves, and aborted kernels on ears.
(5) Tiny, tiny... rodents – some soft and grey, some brown with black stripes, in paintings, posters, wallcharts, thumb-tacked magazine clippings and poorly executed crayon drawings, hurling themselves fatally in their thousands over the cliff of their island home; or crudely taxidermied and mounted, eyes glazed and little paws frozen stiff – on every available surface.
(6) Although the drugs did not cause a desegregation of the eye-specific stripes, treated retinal axon arbors covered about half the area covered by untreated arbors or arbors treated with inactive analogs of the drugs.
(7) In the outer stripe only those proximal straight tubules (P3 segments) farthest from the vascular bundles were damaged.
(8) Many of Long’s pieces are fragile and fleeting: a stripe of un-mown grass in an otherwise close cropped lawn at the Henry Moore foundation , a misty circle in Scotland that lasted only until the day warmed up, a stripe of green grass left by plucking daisies, or paintings in wet mud that dry out and crumble.
(9) The two major proteins found in plants infected with rice stripe virus (RSV), coat protein and a major nonstructural protein (major NS), were purified and their partial amino acid sequences were determined.
(10) Urea production from arginine was studied in vitro in the kidney of normal rats in tubule suspensions of the four different renal zones (cortex, outer and inner stripe of outer medulla, and inner medulla), and in individual microdissected nephron segments.
(11) In monocularly enucleated monkeys, patches are larger and darker above and below the ocular dominance stripes of the remaining eye than in the alternate stripes.
(12) (2) The interstitium of the cortex and of the outer stripe of the outer medulla is significantly widened in most cases of ARF.
(13) With it sank my suitcase of clothes and my striped prisoner uniform, including my hat, coat, shirt and a knife.
(14) Linkage crosses and X-autosome translocations were used to assign short antenna to the right arm of chromosome 3 about 45 map units proximal to stripe (st+), and melanotic was located on chromosome 2 near the centromere.
(15) We have mapped the entire system of OD stripes in the New World monkey Cebus, by means of cytochrome oxidase histochemistry after monocular enucleation.
(16) These are localized in the outer stripe of the renal medulla and are functionally coupled to adenylyl cyclase inhibitor (Gi) G-proteins.
(17) The level of COXII protein is also specifically reduced in the striped plants relative to that of control plants.
(18) Potentiation of heart muscle stripes of the right ventricle was investigated in normal rats (NT-group) and in rats stressed by swimming (HT-group).
(19) The data of 29 subjects totaling more than 21,000 stripe detection events showed that coated photochromic prescription lenses performed better by day and poorer by night compared to uncoated white crown prescription lenses, and that a multiple-layer coated, tinted lens (Neo Multicoat) performed at least as well, day or night, as did the uncoated white crown lens.
(20) With an ambient potassium concentration of 2.5 mM, collecting tubules obtained from the inner stripe of the outer medulla of KD animals absorbed significantly less total CO2 than control tubules.