(n.) A source, or origin; that from which anything proceeds; fundamental substance or energy; primordial substance; ultimate element, or cause.
(n.) An original faculty or endowment.
(n.) A fundamental truth; a comprehensive law or doctrine, from which others are derived, or on which others are founded; a general truth; an elementary proposition; a maxim; an axiom; a postulate.
(n.) A settled rule of action; a governing law of conduct; an opinion or belief which exercises a directing influence on the life and behavior; a rule (usually, a right rule) of conduct consistently directing one's actions; as, a person of no principle.
(n.) Any original inherent constituent which characterizes a substance, or gives it its essential properties, and which can usually be separated by analysis; -- applied especially to drugs, plant extracts, etc.
(v. t.) To equip with principles; to establish, or fix, in certain principles; to impress with any tenet, or rule of conduct, good or ill.
Example Sentences:
(1) Stress is laid on certain principles of diagnostic research in the event of extra-suprarenal pheochromocytomas.
(2) However, as the same task confronts the Lib Dems, do we not now have a priceless opportunity to bring the two parties together to undertake a fundamental rethink of the way social democratic principles and policies can be made relevant to modern society.
(3) To a supporter at the last election like me – someone who spoke alongside Nick Clegg at the curtain-raiser event for the party conference during the height of Labour's onslaught on civil liberties, and was assured privately by two leaders that the party was onside about civil liberties – this breach of trust and denial of principle is astonishing.
(4) The White House denied there had been an agreement, but said it was open in principle to such negotations.
(5) Using the MTT assay and analyzing the data using the median-effect principle, we showed that synergistic cytotoxic interactions exist between CDDP and VM in their liposomal form.
(6) The heretofore "permanently and totally disabled versus able-bodied" principle in welfare reforms is being abbandoned.
(7) The binding follows the principle of isotope dilution in the physiologic range of vitamin B12 present in human serum.
(8) The principle of the liquid and solid two-phase radioimmunoassay and its application to measuring the concentrations of triiodothyronine and thyroxine of human serum in a single sample at the same time are described in this paper.
(9) Spectrophotometric tests for the presence of a lysozyme-like principle in the serum also revealed similar trends with a significant loss of enzyme activity in 2,4,5-T-treated insects.
(10) All these strains produced an enterotoxic principle, antigenically related to cholera coli family of enterotoxins, as detected by latex agglutination and immuno-dot-blot tests.
(11) The basic principle of the resonant tool, its adaptation for surgery, the experimental results of its use in animals, and clinical experience are reported.
(12) It seems tragic, then, that so little of these principles transfer over to the container in which the work is done.
(13) This conception of the city as an expression of both regal power and social order, guided by cosmological principles and the pursuit of yin-yang equilibrium, was unlike anything in the western tradition.
(14) The general principles of bypass surgery as they affect the cerebral circulation are reviewed.
(15) The interest of this view resides in the resulting general principle of classification and interpretation of all forms of disease, giving rise to an "existenialistic pathology".
(16) Eight of the UK's biggest supermarkets have signed up to a set of principles following concerns that they were "failing to operate within the spirit of the law" over special offers and promotions for food and drink, the Office of Fair Trading has said.
(17) Although the general guiding principle of pharmacotherapy for anxiety disorders--the lowest effective dose for the shortest possible time--remains, this rule should not interfere with the judicious use of medications as long as the benefits justify it.
(18) In older stages, the cervical joints rotate according to geometric and lever arm principles.
(19) Spain’s constitutional court responded by unanimously ruling that the legislation had ignored and infringed the rules of the 1978 constitution , adding that the “principle of democracy cannot be considered to be separate from the unconditional primacy of the constitution”.
(20) The principles and practice of aneasthesia for patients having coronary bypass grafts are discussed.
Rationale
Definition:
(a.) An explanation or exposition of the principles of some opinion, action, hypothesis, phenomenon, or the like; also, the principles themselves.
Example Sentences:
(1) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
(2) The nature of the putative autoantigen in Graves' ophthalmopathy (Go) remains an enigma but the sequence similarity between thyroglobulin (Tg) and acetylcholinesterase (ACHE) provides a rationale for epitopes which are common to the thyroid gland and the eye orbit.
(3) The rationale for using the high-risk-group research design in the search for the aetiology of schizophrenia is described.
(4) Pathophysiologic mechanisms and rationale for treatment are discussed.
(5) The rationale for this assumption seems logical because using all of the available accommodation is not sustainable without discomfort.
(6) The rationale for the use of exercise as part of the treatment program in type II diabetes is much clearer and regular exercise may be prescribed as an adjunct to caloric restriction for weight reduction and as a means of improving insulin sensitivity in the obese, insulin-resistant individual.
(7) The rationale for diagnosis and therapy is discussed.
(8) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(9) The rationale for using videofluoroscopy for rehabilitation, the implementation of videofluoroscopy for rehabilitation, and indications for using specific rehabilitation techniques during videofluoroscopy will be discussed.
(10) The rationale for pursuing the development and use of germ-line selection and modification techniques is examined in this essay.
(11) An experimental murine malarial model was devised using the highly synchronous species Plasmodium vinckei petteri to test this rationale.
(12) The wide variety of neurobehavioral effects produced by chemicals found in the environment argues for a rationale of tailoring test selection in many situations, particularly those where the range of expected effects has been fairly well established for the chemical under study.
(13) The homology thus revealed not only lends strong support to mechanisms of autoimmunity that invoke the theory of molecular mimicry of viral proteins, but also suggests a rationale for the skeletal muscle target of polymyositis.
(14) The relationship of these findings to the rationale of such procedures as segmental resection in the surgical treatment of breast cancer is discussed.
(15) The rationale of the method is outlined with emphasis on the management of traumatic oedema.
(16) Concluding the two-page survey were open-ended questions addressing the respondent's indications, contraindications, and rationale for using or not using fluoroscopy.
(17) This advantage may provide a rationale for further evaluation of this agent in patients with more widespread ventricular dysfunction.
(18) The evolution of and rationale for the combined surgical approach to coexistent carotid and coronary artery disease is discussed and the literature reviewed.
(19) Whether there is an additional cost-benefit rationale for handwashing with an antimicrobial agent remains to be studied.
(20) The first reviews the problems of heat stress evaluation: it describes the comprehensive approach adopted by ISO standards and in particular the rationale of the Required Sweat Rate index, and presents the work done during the ECSC interlaboratory study, which extends the application of this index to intermittent or fluctuating conditions of exposure.