(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Reach
Definition:
(v. i.) To retch.
(n.) An effort to vomit.
(v. t.) To extend; to stretch; to thrust out; to put forth, as a limb, a member, something held, or the like.
(v. t.) Hence, to deliver by stretching out a member, especially the hand; to give with the hand; to pass to another; to hand over; as, to reach one a book.
(v. t.) To attain or obtain by stretching forth the hand; to extend some part of the body, or something held by one, so as to touch, strike, grasp, or the like; as, to reach an object with the hand, or with a spear.
(v. t.) To strike, hit, or touch with a missile; as, to reach an object with an arrow, a bullet, or a shell.
(v. t.) Hence, to extend an action, effort, or influence to; to penetrate to; to pierce, or cut, as far as.
(v. t.) To extend to; to stretch out as far as; to touch by virtue of extent; as, his land reaches the river.
(v. t.) To arrive at; to come to; to get as far as.
(v. t.) To arrive at by effort of any kind; to attain to; to gain; to be advanced to.
(v. t.) To understand; to comprehend.
(v. t.) To overreach; to deceive.
(v. i.) To stretch out the hand.
(v. i.) To strain after something; to make efforts.
(v. i.) To extend in dimension, time, amount, action, influence, etc., so as to touch, attain to, or be equal to, something.
(v. i.) To sail on the wind, as from one point of tacking to another, or with the wind nearly abeam.
(n.) The act of stretching or extending; extension; power of reaching or touching with the person, or a limb, or something held or thrown; as, the fruit is beyond my reach; to be within reach of cannon shot.
(n.) The power of stretching out or extending action, influence, or the like; power of attainment or management; extent of force or capacity.
(n.) An extended portion of land or water; a stretch; a straight portion of a stream or river, as from one turn to another; a level stretch, as between locks in a canal; an arm of the sea extending up into the land.
(n.) An artifice to obtain an advantage.
(n.) The pole or rod which connects the hind axle with the forward bolster of a wagon.
Example Sentences:
(1) Philip Shaw, chief economist at broker Investec, expects CPI to hit 5.1%, just shy of the 5.2% reached in September 2008, as the utility hikes alone add 0.4% to inflation.
(2) The final number of fibers--140,000-165,000--is reached by the sixth week after birth.
(3) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(4) Here we show that this induction of AP-2 mRNA is at the level of transcription and is transient, reaching a peak 48-72 hr after the addition of RA and declining thereafter, even in the continuous presence of RA.
(5) The peak molecular weight never reached that of a complete 2:1 complex.
(6) After vascular injury, smooth muscle cells proliferate, reaching a maximum rate at day 2.
(7) Since the start of this week, markets have been more cautious, with bond yields in Spain reaching their highest levels in four months on Tuesday amid concern about the scale of the austerity measures being imposed by the government and fears that the country might need a bailout.
(8) Both development of EDTA-resistant fibrinogen binding and fibrinogen association with the cytoskeleton were time dependent and reached maxima 45 to 60 minutes after fibrinogen binding to stimulated platelets.
(9) Foetal serum TSH concentration declined significantly between 20 and 21 days of gestation, reached a low level at delivery, and remained low for several days after birth.
(10) The highest antishock effect of dopamine is reached when cardiac output fraction addressed to thoracic region vitals is supported by dopamine on the 43-45% level.
(11) Earlier this month, Khamenei insisted that all sanctions be lifted immediately on a deal being reached, a condition that the US State Department dismissed.
(12) This indicates that [Ca2+]i may reach greater than 10 microM during an RCC.
(13) Keep it in the ground campaign Though they draw on completely different archives, leaked documents, and interviews with ex-employees, they reach the same damning conclusion: Exxon knew all that there was to know about climate change decades ago, and instead of alerting the rest of us denied the science and obstructed the politics of global warming.
(14) The move to an alliance model is not only to achieve greater scale and reach, although growing from 15 partner organisations to 50 members is not to be sniffed at.
(15) It is possible that the elements provide common precursor proteins that reach the secretory intermediate lobe cells through their dendritic branches.
(16) More evil than Clocky , the alarm clock that rolls away when you reach out to silence it, or the Puzzle Alarm , which makes you complete a simple puzzle before it'll go quiet, the Money Shredding Alarm Clock methodically destroys your cash unless you rouse yourself.
(17) A failure to reach a solution would potentially leave 200,000 homes without affordable cover, leaving owners unable to sell their properties and potentially exposing them to financial hardship.
(18) These O2-exposed cells were resistant to 4HNE, requiring 2.6 times as long in 80 microM 4HNE to reach 30% survival as compared to density-matched normoxia control.
(19) But the amount of time spent above SPA has differed substantially between men and women due to women both living longer, and reaching state pension age earlier.
(20) He said the 8.13am train from the French capital to London reached Calais before suffering “network problems”.