(n.) To make lax or loose; to make less close, firm, rigid, tense, or the like; to slacken; to loosen; to open; as, to relax a rope or cord; to relax the muscles or sinews.
(n.) To make less severe or rigorous; to abate the stringency of; to remit in respect to strenuousness, earnestness, or effort; as, to relax discipline; to relax one's attention or endeavors.
(n.) Hence, to relieve from attention or effort; to ease; to recreate; to divert; as, amusement relaxes the mind.
(n.) To relieve from constipation; to loosen; to open; as, an aperient relaxes the bowels.
(v. i.) To become lax, weak, or loose; as, to let one's grasp relax.
(v. i.) To abate in severity; to become less rigorous.
(v. i.) To remit attention or effort; to become less diligent; to unbend; as, to relax in study.
(n.) Relaxation.
(a.) Relaxed; lax; hence, remiss; careless.
Example Sentences:
(1) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(2) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(3) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(4) In in vitro preparations GABA (10(-7) - 10(-3) M) elicited a dose-dependent relaxation; a decrease in the spontaneous contractions was sometimes observed.
(5) Anaesthesia was achieved by a mixture of oxygen, nitrous oxide and fluothane without use of muscle relaxants.
(6) A more accurate fit of T1 data using a modified Lipari and Szabo approach indicates that internal fast motions dominate the T1 relaxation in glycogen.
(7) Endothelium-dependent relaxations to acetylcholine and endothelium-independent relaxations to nitric oxide were observed in rings from both strains during contraction with endothelin.
(8) Relaxation situations are marked by relaxation, usually after a meal.
(9) The rabbits were either breathing spontaneously or were ventilated by a phrenic nerve-controlled servorespirator without the use of muscle relaxants.
(10) For each RG patient, two sex, age, and initial diastolic blood pressure (DBP) matched controls were found, obtaining thus a control group (CG) consisting of 70 hypertensive patients who were not participating in any relaxation program.
(11) Under the condition in which ryanodine (10-100 microM) treatment was found to cause the SR to be nonfunctional, pinacidil relaxation DRC remained unaltered, suggesting a lack of a stimulatory effect of pinacidil on SR Ca++ accumulation.
(12) which suggest that ~60-90% of the cross-bridges attached in rigor are attached in relaxed fibers at an ionic strength of 20 mM and ~2-10% of this number of cross-bridges are attached in a relaxed fiber at an ionic strength of 170 mM.
(13) Trimazosin at the dose used and under the conditions of study did not reverse the peripheral pressor effect of angiotensin II or B-HT920 but at higher concentrations, unlike prazosin, it relaxed the K+ contracted thoracic aorta.
(14) The relaxations in response to a nonreceptor-mediated endothelium-dependent vasodilator, A23187, and an endothelium-independent vasodilator, sodium nitroprusside, were not different between normal and diabetic aortas.
(15) Nitric oxide (NO) is a major component of endothelium-derived relaxing factor (EDRF) the synthesis of which from L-arginine can be inhibited by NG-monomethyl-L-arginine (L-NMMA).
(16) Binding to HSA occurs primarily with the imidazolidine and thiazolidine groups of levamisole as it has been demonstrated by selective changes in the relaxation times and the chemical shifts of the protons attached to the carbon atoms.
(17) We conclude that gastric adaptive relaxation remains abnormal in patients with postvagotomy diarrhoea but not in those who are asymptomatic or who have other symptoms.
(18) Nitric oxide (NO) induced tetrodotoxin-resistant NANC relaxation, similar to that induced by electrical stimulation or acetylcholine (ACh).
(19) Treatment of bacterial cells with inhibitors of gyrase at high concentration leads to relaxation of DNA supercoils, presumably through interference with the supercoiling activity of gyrase.
(20) The kinetics of extracellular neutral proteinase synthesis by an isogenic stringent (IS58) and a relaxed (IS56) strain of B. subtilis were compared.
Unwind
Definition:
(v. t.) To wind off; to loose or separate, as what or convolved; to untwist; to untwine; as, to unwind thread; to unwind a ball of yarn.
(v. t.) To disentangle.
(v. i.) To be or become unwound; to be capable of being unwound or untwisted.
Example Sentences:
(1) Unlike cisplatin, bis(platinum) complex binding does not unwind supercoiled DNA.
(2) Of the 47 compounds that were positive or equivocal in the alkaline unwinding assay, only carbon tetrachloride and prednisolone were negative in the mouse lymphoma assay, while 12 of the 19 compounds that were negative in the alkaline unwinding assay were positive in the mouse lymphoma assay.
(3) As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing cylindrical inclusion (CI) protein from plum pox virus (PPV), which belongs to the potyvirus group of positive strand RNA viruses, is shown to be able to unwind RNA duplexes.
(4) This limited unwinding of heterologous duplex DNA, termed heterologous unwinding, was detected within 30 seconds and reached a steady state within a few minutes.
(5) Comparison of the superhelix densities obtained by both methods permits a calculation of an unwinding angle for ethidium.
(6) The exposure of the cells from mussel haemolymph and from mouse L1210 to a genotoxic compound such as dimethylsulfate results in DNA damage and consequently in a reduction of the unwinding time.
(7) As for unwinding, the rituals of it give a satisfying end to the shape of my day.
(8) Chromosome replication appears to initiate in E. coli when the dnaA boxes in oriC become filled with DnaA protein, which could simultaneously mediate both the unwinding of the origin for the start of polymerization and the attachment of oriC to the cell envelope (Bramhill and Kornberg, 1988; Løbner-Olesen et al., 1989; Pierucci et al., 1989).
(9) The protein fraction containing the 93 000 dalton protein had considerable unwinding activity, depressing the melting temperature of poly(dA-dT) by 39 degrees C. The protein fraction containing the bulk of the 35 000 dalton protein did not have unwinding activity.
(10) The required cellular protein may be a eukaryotic single-stranded-DNA-binding protein (SSB), since unwinding of the template is also observed when Escherichia coli SSB is substituted for the HeLa protein fraction.
(11) Evidence is presented that the first step in initiation of SV40 DNA replication involves the specific binding of T antigen to the origin, followed by the local unwinding of the two strands of the template.
(12) Complex formation leads to very little, if any, unwinding of the duplex.
(13) It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.
(14) Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I.
(15) We used an RNA unwinding assay to compare the activities of these factors from the different species.
(16) The extension and unwinding of the DNA helix brought about by the intercalating chromophore of the dye molecules are not requirements for the entrapment process.
(17) Second, mutant T antigens with impaired ATPase function also showed a reduced DNA unwinding activity.
(18) Analysts at UBS said: “After Friday’s ... market plunge, many turned to the authorities for support measures as concerns rose that the rapid unwinding of margin trades was fuelling the sell-off.
(19) It is proposed that the DNA-unwinding activity causes the efficient recombination, DNA repair, and SOS induction (after application of nalidixic acid) in recD mutants.
(20) But within minutes of the five-year-old video of Obama being released by the Daily Caller website on Tuesday night , the "exclusive" began to unwind amid criticism that much of it had been reported at the time and the content was anything but explosive.