(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Target
Definition:
(n.) A kind of small shield or buckler, used as a defensive weapon in war.
(n.) A butt or mark to shoot at, as for practice, or to test the accuracy of a firearm, or the force of a projectile.
(n.) The pattern or arrangement of a series of hits made by a marksman on a butt or mark; as, he made a good target.
(n.) The sliding crosspiece, or vane, on a leveling staff.
(n.) A conspicuous disk attached to a switch lever to show its position, or for use as a signal.
Example Sentences:
(1) The resulting dose distribution is displayed using traditional 2-dimensional displays or as an isodose surface composited with underlying anatomy and the target volume.
(2) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(3) The fraction of the viral dose which became cell associated was independent of the incubation temperature and increased with increasing target membrane concentration.
(4) The binding properties of formalin-fixed amelanotic melanoma cells were not identical to those of endothelial or unfixed target cells.
(5) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(6) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(7) After midazolam infusion, there was a 50% decrease in amplitude of P3 in response to target tones (P less than 0.006), whereas N3 latency increased by 40 ms (P less than 0.05).
(8) In the absence of an authentic target for the MASH proteins, we examined their DNA binding and transcriptional regulatory activity by using a binding site (the E box) from the muscle creatine kinase (MCK) gene, a target of MyoD.
(9) Despite a 10-year deadline to have the same number of ethnic minority officers in the ranks as in the populations they serve, the target was missed and police are thousands of officers short.
(10) A 24-h test trial employing a dry target demonstrated a robust memory for the training manifested in passive avoidance behavior.
(11) For related pairs, both the primes (first pictures) and targets (second pictures) varied in rated "typicality" (Rosch, 1975), being either typical or relatively atypical members of their primary superordinate category.
(12) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(13) Charge data from the target hospital showed a statistically significant reduction in laboratory charges per patient in the quarter following program initiation (P = 0.02) and no evidence for change in a group of five comparison hospitals.
(14) Consequently, it is important to predict accurately dose for such fields to ensure adequate coverage of the target region and sparing of healthy tissues.
(15) Three effector: target ratios (6.2:1, 25:1, and 50:1) were studied in quadruplicate using 3, 4 and 5-h incubations.
(16) It is proposed that microoscillations of the eye increase the threshold for detection of retinal target displacements, leading to less efficient lateral sway stabilization than expected, and that the threshold for detection of self motion in the A-P direction is lower than the threshold for object motion detection used in the calculations, leading to more efficient stabilization of A-P sway.
(17) However, since these levels were unaltered by reducing the antiandrogen dosage, the main action of the therapy is probably that of the antiandrogen within the target cells.
(18) We are pleased to see the process moving forward and look forward to its resolution,” a Target spokeswoman, Molly Snyder, said in an emailed statement.
(19) The matter is now in the hands of the Guernsey police and the law officers.” One resident who is a constant target of the paper and has complained to police, Rosie Guille, said the allegations had a “huge impact on morale” on the island.
(20) This article describes a method of selecting a potentially successful strategy using a combination of two factors: change target and level of change willingness and ability.