(a.) Undisturbed by passion or caprice; calm; tranquil; serene; not passionate or giddy; composed; staid; as, a sedate soul, mind, or temper.
Example Sentences:
(1) The effects of sessions, individual characteristics, group behavior, sedative medications, and pharmacological anticipation, on simple visual and auditory reaction time were evaluated with a randomized block design.
(2) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
(3) However, the degree of sedation caused by diphenhydramine was significantly greater than that caused by cimetidine (P = .0001).
(4) Although lorazepam and haloperidol produced an equivalent mean decrease in aggression, significantly more subjects who received lorazepam had a greater decrease in aggression ratings than haloperidol recipients; this effect was independent of sedation.
(5) Adverse outcomes were reported more frequently by consultant physicians, by those who 'titrated' the intravenous sedative, and by those who used an additional intravenous agent, but were reported equally frequently by endoscopists using midazolam and endoscopists using diazepam.
(6) Alterations in mean systolic blood pressure appeared to be modest, consisting of a 10 percent decrease from the control level, related to sedation, and a 10 percent rise from baseline during the procedure, associated with a concomitant mild tachycardia.
(7) We have evaluated the action of hypnotics on the sleep-wakefulness cycle in freely implanted rats during their maximally active period because it is easier to estimate the duration of the sedative effect.
(8) A survey into the current usage of tracheal tubes and associated procedures, such as various sedation regimes and antacid therapy, in intensive care units was carried out in Sweden by sending a questionnaire to physicians in charge of intensive care units in 70 acute hospitals which included seven main teaching hospitals.
(9) The results show that both drugs possess sedative, antispasmodic, antipyretic, antiinflammatory, cardiotonic and hypotensive effects, the strength of effect and toxicity being similar.
(10) This suggests that the fluphenazine-induced sedation is not mediated via its effect on brain NA content, but is possibly due to the effect of the drug on NA turnover rates in the brain.
(11) The introduction of non-sedating H1-selective antihistamine drugs and local corticosteroids has been an important therapeutic advance.
(12) Neither a sedative nor other side effects could be seen.
(13) Sedation was measured by asking the subjects to complete visual analog scales.
(14) Smoking behaviour, self-reported mood and cardiac activity were examined in 12 "sedative" and 12 "stimulant" smokers, defined using Mangan and Golding's questionnaire.
(15) Patients in the reference group used more sedatives and long-acting nitroglycerine and had a lower return-to-work rate during the study period.
(16) A prospective study of the necessity of sedation, or analgesia, or both in total colonoscopy was performed.
(17) Fifteen consecutive patients on peritoneal dialysis who complained of chronic sleep disturbance and requested sedative were selected.
(18) Sedative interaction between midazolam and morphine was found to have a tendency for synergism (interaction coefficient of 1.56, P greater than 0.05) with decreased individual variability in the sedative response to the combination.
(19) Both drugs were relatively well tolerated, but trimipramine had a sedative effect which proved troublesome in some patients.
(20) None of the patients required anaesthesia, analgesics or sedatives.
Sleep
Definition:
() imp. of Sleep. Slept.
(v. i.) To take rest by a suspension of the voluntary exercise of the powers of the body and mind, and an apathy of the organs of sense; to slumber.
(v. i.) To be careless, inattentive, or uncouncerned; not to be vigilant; to live thoughtlessly.
(v. i.) To be dead; to lie in the grave.
(v. i.) To be, or appear to be, in repose; to be quiet; to be unemployed, unused, or unagitated; to rest; to lie dormant; as, a question sleeps for the present; the law sleeps.
(v. t.) To be slumbering in; -- followed by a cognate object; as, to sleep a dreamless sleep.
(v. t.) To give sleep to; to furnish with accomodations for sleeping; to lodge.
(v. i.) A natural and healthy, but temporary and periodical, suspension of the functions of the organs of sense, as well as of those of the voluntary and rational soul; that state of the animal in which there is a lessened acuteness of sensory perception, a confusion of ideas, and a loss of mental control, followed by a more or less unconscious state.
Example Sentences:
(1) AEDs may also have differential effects on nighttime sleep.
(2) It is supposed that delta-sleep peptide along with other oligopeptides is one of the factors determining individual animal resistance to emotional stress, which is supported by significant delta-sleep peptide increase in hypothalamus in stable rats.
(3) For assessment of clinical status, investigators must rely on the use of standardized instruments for patient self-reporting of fatigue, mood disturbance, functional status, sleep disorder, global well-being, and pain.
(4) We investigated whether these peptides also affect the sleep EEG in humans when given intravenously by comparing polysomnographically the effects of four boluses of (1) placebo, (2) 50 micrograms GHRH or (3) 50 micrograms SRIF administered at 22.00, 23.00, 24.00 and 1.00 h to 7 male controls.
(5) Polygraphic recordings during sleep were performed on 18 elderly persons (age range: 64-100 years).
(6) This was carried out on the healthy subjects for a total of 12 nights without medication (control nights asleep), a total of 12 nights following 40 mg of flucortolone the previous morning, and a total of 6 nights with similar blood sampling when sleep was prevented (control nights awake).
(7) Although temazepam was effective for maintaining sleep with short-term use, there was rapid development of tolerance for this effect with intermediate-term use.
(8) The occurrence of episodes of desaturation during sleep in patients suffering from chronic airflow obstruction is well known.
(9) A lower than normal percentage of REM sleep in these patients was consistent with their retarded intellectual development, which supports current thinking that REM sleep may be a sensitive index of brain function integrity.
(10) Amine metabolites, 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA) were not substantially affected by sleep deprivation, although there was a significant interaction of clinical response and direction of 3-methoxy-4-hydroxyphenylglycol (MHPG) change.
(11) Results of sleep sampling under electroencephalographic control of the assessment of GH secretion are comparable to conventional pharmacological studies in terms of efficiency, sensitivity, and percentage false-negatives.
(12) Sleep was defined behaviorally as failure to respond to the faint auditory RT cue.
(13) We have evaluated the action of hypnotics on the sleep-wakefulness cycle in freely implanted rats during their maximally active period because it is easier to estimate the duration of the sedative effect.
(14) However, patients can be taught how to retard the onset of wrinkles by avoiding unprotected sun exposure, unnecessary facial movements, and certain sleeping positions.
(15) The analogy with infant sleep patterns and results of studies of brain function in narcoleptics suggest that forebrain inhibitory processes are more important in narcoleptic symptomology than is brainstem dysfunction.
(16) In short term clinical studies, the beneficial effects of transdermal estradiol on plasma gonadotrophins, maturation of the vaginal epithelium, metabolic parameters of bone resorption and menopausal symptoms (hot flushes, sleep disturbance, genitourinary discomfort and mood alteration) appear to be comparable to those of oral and subcutaneous estrogens, while the undesirable effects of oral estrogens on hepatic metabolism are avoided.
(17) Sleep alterations in addicted newborns could be related to central nervous system (CNS) distress caused by withdrawal.
(18) "Our black, Muslim and Jewish citizens will sleep much less easily now the BBC has legitimised the BNP by treating its racist poison as the views of just another mainstream political party when it is so uniquely evil and dangerous."
(19) Stage REM frequently appeared within 10 min of stage 1 onset and the normal sequence of stages REM and 4 were altered, demonstrating that the organization of sleep within a nap is quite different from that in monophasic nocturnal sleep.
(20) This result is discussed in terms of either a function of time-of-day effect or of prior sleep intensity.