(a.) allaying irritability and irritation; assuaging pain.
(n.) A remedy which allays irritability and irritation, and irritative activity or pain.
Example Sentences:
(1) The effects of sessions, individual characteristics, group behavior, sedative medications, and pharmacological anticipation, on simple visual and auditory reaction time were evaluated with a randomized block design.
(2) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
(3) However, the degree of sedation caused by diphenhydramine was significantly greater than that caused by cimetidine (P = .0001).
(4) Although lorazepam and haloperidol produced an equivalent mean decrease in aggression, significantly more subjects who received lorazepam had a greater decrease in aggression ratings than haloperidol recipients; this effect was independent of sedation.
(5) Adverse outcomes were reported more frequently by consultant physicians, by those who 'titrated' the intravenous sedative, and by those who used an additional intravenous agent, but were reported equally frequently by endoscopists using midazolam and endoscopists using diazepam.
(6) Alterations in mean systolic blood pressure appeared to be modest, consisting of a 10 percent decrease from the control level, related to sedation, and a 10 percent rise from baseline during the procedure, associated with a concomitant mild tachycardia.
(7) We have evaluated the action of hypnotics on the sleep-wakefulness cycle in freely implanted rats during their maximally active period because it is easier to estimate the duration of the sedative effect.
(8) A survey into the current usage of tracheal tubes and associated procedures, such as various sedation regimes and antacid therapy, in intensive care units was carried out in Sweden by sending a questionnaire to physicians in charge of intensive care units in 70 acute hospitals which included seven main teaching hospitals.
(9) The results show that both drugs possess sedative, antispasmodic, antipyretic, antiinflammatory, cardiotonic and hypotensive effects, the strength of effect and toxicity being similar.
(10) This suggests that the fluphenazine-induced sedation is not mediated via its effect on brain NA content, but is possibly due to the effect of the drug on NA turnover rates in the brain.
(11) The introduction of non-sedating H1-selective antihistamine drugs and local corticosteroids has been an important therapeutic advance.
(12) Neither a sedative nor other side effects could be seen.
(13) Sedation was measured by asking the subjects to complete visual analog scales.
(14) Smoking behaviour, self-reported mood and cardiac activity were examined in 12 "sedative" and 12 "stimulant" smokers, defined using Mangan and Golding's questionnaire.
(15) Patients in the reference group used more sedatives and long-acting nitroglycerine and had a lower return-to-work rate during the study period.
(16) A prospective study of the necessity of sedation, or analgesia, or both in total colonoscopy was performed.
(17) Fifteen consecutive patients on peritoneal dialysis who complained of chronic sleep disturbance and requested sedative were selected.
(18) Sedative interaction between midazolam and morphine was found to have a tendency for synergism (interaction coefficient of 1.56, P greater than 0.05) with decreased individual variability in the sedative response to the combination.
(19) Both drugs were relatively well tolerated, but trimipramine had a sedative effect which proved troublesome in some patients.
(20) None of the patients required anaesthesia, analgesics or sedatives.
Soporific
Definition:
(a.) Causing sleep; tending to cause sleep; soporiferous; as, the soporific virtues of opium.
(n.) A medicine, drug, plant, or other agent that has the quality of inducing sleep; a narcotic.
Example Sentences:
(1) The maximum soporific effect did not occur until 90-120 s after injection.
(2) His answer threatened a soporific summer-long contest that would expose a great gap between the self-styled people's party and the people themselves.
(3) 'P ublic sector commissioning": I can't think of a phrase that conveys something so important and yet sounds so soporific.
(4) Soporific effect of hexenal was distinctly increased in the burns, which correlated to the severity of thermic impairment.
(5) Pebble-dashed walls, red roof tiles, Velux windows, cherry trees... these things make me think not of daring strokes of oil on canvas, but of the safe, the soporific - a round of golf, perhaps, or a gentle Sunday-night sitcom.
(6) Less drugs were used in general, and the use of tranquillizers and soporifics was cut down to a third.
(7) Higher doses of naloxone (1Opmol into the LC) were however, required to antagonize the behavioural and ECoG soporific effects induced by the Kappa-receptor agonist U 50,488H.
(8) The drug is well tolerated by the patients and does not produce any inhibitory or soporific action.
(9) And, intriguingly, a 2009 study at Mashhad University in Iran revealed an extract of saffron did have soporific qualities, on mice at least.
(10) Instead, the atmosphere is soporific, with an underlying threat of menace.
(11) Toxicological urine analysis for drugs--directed mainly at soporifics, sedatives, tranquilizers, and pain-relievers--on 84 patients involved in industrial accidents yielded the following results.
(12) What had been a sombre occasion for City fans as they looked at an Etihad Stadium dugout without Mancini for a first time since December 2009 became further muted when a soporific start to the game had ended with Anthony Pilkington opening the scoring for Norwich.
(13) 1 Experiments were performed on a variety of tissues from different species to establish whether or not the properties of p-chlorophenylalanine methyl ester (PCPA) included a 5-hydroxytryptamine (5-HT)-like action which might explain the soporific action of PCPA in chicks.
(14) Because of their pharmacologic action, alcohol and high doses of soporifics used as remedies may produce REM-deficit sleep and actually prolong insomnia.
(15) Imagine my surprise in the morning to find it was gone 7am – the soporific effect of the loud snoring made my baby sleep through the night for the first time!
(16) Long sleep (LS) and short sleep (SS) mice have a differential sensitivity to the behavioral actions of an adenosine agonist, R-phenylisopropyl-adenosine (PIA) that parallels their differential sensitivity to the soporific effects of ethanol.
(17) If so, the soporific way Per Mertesacker dawdled in possession and Kieran Gibbs clumsily punted the ball into the air suggested there had been scant impact.
(18) After 53 days of alcohol ingestion there was no evidence of tolerance to the soporific effects of parenterally administered ethanol and removal of the ethanol solutions failed to produce any signs of alcohol withdrawal.
(19) Further, much evidence also supports the conclusion that most of these hypnotic-depressants and anesthetics could exert their soporific influence by a potentiation of GABA activity.
(20) Recent evidence, as well as reevaluated previous evidence, indicates that Long-Sleep mice are more sensitive to the soporific effects of three major classes of CNS depressants (alcohols, barbiturates, and benzodiazepines), as well as many other anesthesia-inducing compounds (adenosine, chloral hydrate, trichloroethanol, paraldehyde, nitrous oxide, enflurane, and isoflurane).