(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
Stark
Definition:
(n.) Stiff; rigid.
(n.) Complete; absolute; full; perfect; entire.
(n.) Strong; vigorous; powerful.
(n.) Severe; violent; fierce.
(n.) Mere; sheer; gross; entire; downright.
(adv.) Wholly; entirely; absolutely; quite; as, stark mind.
(v. t.) To stiffen.
Example Sentences:
(1) World leaders must reach a historic agreement to fight climate change and poverty at coming talks in Paris, facing the stark choice to either “improve or destroy the environment”, Pope Francis said in Africa on Thursday.
(2) Facebook Twitter Pinterest No shake: Donald Trump snubs Angela Merkel during photo op The piece of pantomime was in stark contrast to the visit of Theresa May in January.
(3) But as a former Eurocrat, he is well-versed in the weaknesses and believes it is right to highlight them in stark language.
(4) These achievements, and faults, will find stark contrast with Trump’s administration; certainly Trump’s nominations for key positions in his cabinet that relate to climate change have prompted alarm by experts and campaigners.
(5) An ethnic breakdown of other opinion-formers, from book reviewers to theatre critics, would be just as stark.
(6) Paul*, from Essex, a father of two daughters, has experienced those starkly differing standards.
(7) Friends of the Earth's executive director, Andy Atkins, said: "We can't continue to ignore the stark warnings of the catastrophic consequences of climate change on the lives and livelihoods of people across the planet.
(8) She went on to deliver a stark warning that leaving the single market would deter international investors from Britain and lead major companies to question whether they should relocate to mainland Europe.
(9) This was in stark contrast to my comprehensive school.
(10) Their differences highlight Northern Ireland’s often stark dichotomy between religious-based social conservatism and secular progressive liberalism.
(11) By global city standards even those are quite clean and orderly, but compared with the rest of the city they offer a stark contrast.
(12) Dig deeper into the funding numbers – the real story of national politics in the post Citizens United age – and the Tea Party realignment of the GOP stands out yet more starkly.
(13) The inequalities that have been allowed to emerge in this one street are so stark they recall an era as long past as the period of its houses.
(14) A glance at today's Sun provides a stark reminder that constitutional reform is no way to win easy plaudits from the papers that most voters read.
(15) Although the Kyoto agreement only measures production, the stark difference in the figures highlights a key controversy in negotiations about a new treaty – which will continue at a big UN meeting in Cancún, Mexico, in December : some developing countries, such as China, argue they should not be held responsible for emissions generated by consumption in rich nations.
(16) It is a stark contrast to expectations before the vote to leave the EU, when the next move in interest rates was seen as likely to be upwards.
(17) The next few days may well determine whether, this time, such loyalty will be in vain; but, while yearning for a clarion call and what was described as "vision" in this paper's leading article yesterday, I need to pose some pretty stark questions to Guardian readers.
(18) They included Lena Heady (Queen Cersei Lannister), Kit Harington (Jon Snow), Conleth Hill (Lord Varys), Rose Leslie (Ygritte), 17-year-old Maisie Williams (Arya Stark) and 18-year-old Sophie Turner (Sansa Stark).
(19) The orderly village of Agulodiek in Ethiopia's western Gambella region stands in stark contrast to Elay, a settlement 5km west of Gambella town, where collapsed straw huts strewn with cracked clay pots lie among a tangle of bushes.
(20) The next three years of negotiations on the treaty will be the hardest in the 20-year history of climate change talks because the world has changed enormously since 1992, when the UN convention on climate change was signed, and 1997, when the Kyoto protocol enshrined a stark division between developed countries – which were required to cut emissions – and developing countries, which were not.