(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
Stiff
Definition:
(superl.) Not easily bent; not flexible or pliant; not limber or flaccid; rigid; firm; as, stiff wood, paper, joints.
(superl.) Not liquid or fluid; thick and tenacious; inspissated; neither soft nor hard; as, the paste is stiff.
(superl.) Firm; strong; violent; difficult to oppose; as, a stiff gale or breeze.
(superl.) Not easily subdued; unyielding; stubborn; obstinate; pertinacious; as, a stiff adversary.
(superl.) Not natural and easy; formal; constrained; affected; starched; as, stiff behavior; a stiff style.
(superl.) Harsh; disagreeable; severe; hard to bear.
(superl.) Bearing a press of canvas without careening much; as, a stiff vessel; -- opposed to crank.
(superl.) Very large, strong, or costly; powerful; as, a stiff charge; a stiff price.
Example Sentences:
(1) If you turn the bowl upside down, the whites should be stiff enough not to fall out.
(2) The stiffness of the fibre first rose abruptly in response to stretch and then started to decrease linearly while the stretch went on; after the completion of stretch the stiffness decreased towards a steady value which was equal to that during the isometric tetanus at the same sarcomere length, indicating that the enhancement of isometric force is associated with decreased stiffness.
(3) Current methodology for the in vitro determination of aortic and large artery stiffness is reviewed and involves three approaches: (1) the estimation of distensibility by pulse wave velocity measurement; (2) the estimation of distensibility from the fractional diameter change of a given arterial segment by imaging techniques (e.g., angiography, Doppler ultrasound) against pressure change; (3) the estimation of compliance by determining volume change against pressure change in the arterial system during diastolic runoff from the Windkessel model of the circulation.
(4) The maintenance of adequate blood circulation requires a sufficient ventricular contractility; in addition, to eject blood, the ventricles must first receive a sufficient volume, requiring a low diastolic stiffness.
(5) Stiffness was reduced in approximate proportion to the ramp stretch rate, and the reduction was confined largely to the elastic component.
(6) Proof stress, ultimate tensile strength, elongation, and plastic stiffness have been measured and results compared by use of analyses of variance.
(7) In other words, the stiffness of these areas was low and the recovery from deformation was fast.
(8) But the same court also just refused to hear an appeal of a Minnesota woman who's been ordered to pay more than $220,000 for downloading two-dozen songs – a testament to Congress' gift to Hollywood and its allies in the form of absurdly stiff penalties for minor infringement.
(9) The tension-length relation for the unstimulated (passive) cell is also linear between 1r and the elastic limit, but is displaced from the active tension-length curve and is of reduced stiffness.
(10) Bilaterals in summit seasons can be stiff exchanges, where digressions can carry risks: not enough said, too much said.
(11) We measured the stiffness of comparable configurations (1 or 2 bars) under axial compression, four-point-bending in two planes, and torsion.
(12) Tiny, tiny... rodents – some soft and grey, some brown with black stripes, in paintings, posters, wallcharts, thumb-tacked magazine clippings and poorly executed crayon drawings, hurling themselves fatally in their thousands over the cliff of their island home; or crudely taxidermied and mounted, eyes glazed and little paws frozen stiff – on every available surface.
(13) The bone stiffness also correlates strongly with the geometry (area) and slightly with bone mass; however, an unexpectedly low correlation was found between stiffness and density.
(14) Finally, fibrosis may paradoxically reduce passive stiffness if it leads to a thinning of the interventricular septum.
(15) A young male nephrotic patient, who was given small doses of clofibrate for hyperlipaemia, developed muscle pain, stiffness and very high serum levels of muscle enzymes.
(16) Impaired left ventricular stiffness may be an additional criterion for using corinfar in patients with coronary heart disease.
(17) The increase of elastic fibres following denervation and reinnervation represents an obviously meaningful reaction that may compensate for loss of tonic properties of muscle spindles without causing stiffness.
(18) Only the bone-patellar tendon-bone unit had maximum force and stiffness greater than that of the ACL.
(19) The initial stiffness is poorly described by material or catheter gauge.
(20) The stiffness tester and torque meter were found to yield nearly the same measurements of bending deformation for orthodontic wires as small as .007 inch diameter, provided the different bending apparatus are calibrated to each other.