(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
Strict
Definition:
(a.) Strained; drawn close; tight; as, a strict embrace; a strict ligature.
(a.) Tense; not relaxed; as, a strict fiber.
(a.) Exact; accurate; precise; rigorously nice; as, to keep strict watch; to pay strict attention.
(a.) Governed or governing by exact rules; observing exact rules; severe; rigorous; as, very strict in observing the Sabbath.
(a.) Rigidly; interpreted; exactly limited; confined; restricted; as, to understand words in a strict sense.
(a.) Upright, or straight and narrow; -- said of the shape of the plants or their flower clusters.
Example Sentences:
(1) Mindful of their own health ahead of their mission, astronauts at the Russia-leased launchpad in Kazakhstan remain in strict isolation in the days ahead of any launch to avoid exposure to infection.
(2) Focal segmental glomerulosclerosis was diagnosed by strict histologic criteria in 103 patients.
(3) Neurospora crassa mitochondrial deoxyribonucleic acid shows strict uniparental inheritance in sexual crosses, with a notable absence of mixtures and recombinant types that appear frequently in heteroplasmons.
(4) Primary vaccination should be carried out as early as possible, while strictly observing the contraindications.
(5) Though no strict relationship could be observed between titers in the IH test and the time it took mice to die from the intravenous inoculation of mice (IIM test), results of the supernatants examined by both methods demonstrated that the IH test was more sensitive than the IIM one.
(6) Strict fundamentalists oppose music in any form as a sensual distraction - the Taliban, of course, banned music in Afghanistan.
(7) Neither assertion was strictly accurate, but Obama was on a rhetorical roll.
(8) They continuously produced heteropolymeric G6PD and showed strictly additive patterns of silver staining of both parental sets of nucleolar organizing chromosomes.
(9) Strict precautions are necessary to prevent the catastrophic events resulting from inadvertent gentamicin injection; such precautions should include precise labeling of all injectable solutions on the surgical field, waiting to draw up injectable antibiotics until the time they are needed, and drawing up injectable antibiotics under direct physician observation.
(10) Orbital hypertelorism, strictly defined as an increase in bony interorbital distance, is not itself an isolated syndrome, but is instead an anomaly that may occur as either part of a syndrome or malformation sequence.
(11) There must also be strict rules in place to reduce the risks they take with shareholders' funds.Yet the huge cost of increasing capital and liquidity is forgotten when the Treasury urges them to increase lending to small and medium businesses.
(12) The occurrence of paresis or paralysis in ischemic processes strictly situated in the thalamus, however, is discussed: the deficit may be limited to parts of limbs; most often, it is not associated with pyramidal symptomatology; recovery is observed in the hand before the inferior limb.
(13) Active sites for thiosulphate are probably strictly connected with cell membranes.
(14) Indications for operation must be strict, for unless there are specific signs and symptoms of appendiceal disease, appendectomy will often be of no benefit.
(15) The uptake of acetyl-L-carnitine was not strictly substrate-specific; gamma-butyrobetaine, L-carnitine, L-DABA, and GABA were potent inhibitors, hypotaurine and L-glutamate were moderate inhibitors, and glycine and beta-alanine were only weakly inhibitory.
(16) The absence of strict restrictions for the feeding on unusual species of hosts has caused the domination of polyphagy and oligophagy over monophagy among ixodid ticks.
(17) Given his background, Boyle says, growing up in a council house near Bury, with his two sisters (one a twin) and his strict and hard-working parents (his mum worked as a dinner lady at his school), he should by rights have been a gritty social realist, but that tradition never appealed to him.
(18) The low amount of 100000-dalton protein and lack of 4-nm surface particles in sarcoplasmic reticulum vesicles obtained from fetal and newborn rabbits are strictly correlated with the low activity of Ca2+-dependent ATPase and the ability to take up Ca2+.
(19) Sensitizing drugs must be strictly avoided to prevent such recurrences: their presence in drug mixtures must be guarded against.
(20) The lack of a strict correlation between the changes in tubulin composition and changes in organization of microtubular structures indicates that accumulation of beta 2-tubulin and disappearance of alpha 3-tubulin isotypes are not sufficient to bring about reorganization of microtubules during development.