(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
Thrashing
Definition:
(p. pr. & vb. n.) of Thresh
() a. & n. from Thrash, v.
Example Sentences:
(1) Out of the seabird whoops and thrashing drumming of the intro to Endangered Species come guitar-sax exchanges that sound like Prime Time’s seething fusion soundscapes made illuminatingly clearer.
(2) After a fairly competitive first set, it turned into a rout almost on the scale of the triple-bagle thrashing the Scot gave the Luxembourg part-timer Laurent Bram when he returned to Davis Cup action in Glasgow four years ago.
(3) Experts say they are encouraged that after months of simmering discord Xi and Trump are preparing to thrash it out at the so-called winter White House .
(4) Yet this was actually City’s second 4-1 beating in their last six league games, following on from the game at Tottenham Hotspur on 26 September, and it finished with their heaviest home defeat since a 5-1 thrashing against Arsenal at Maine Road in February 2003.
(5) So new newspaper enemies turn against the BBC, thrashing around for someone to blame for the danger newspapers are in.
(6) Woodward maintained that it would be simple to thrash out a "straightforward commercial settlement".
(7) 1.49am BST Michael Aston writes: Gota feeling this is going to be a thrashing, a major and total beat down... After watching the Spurs humiliate the Heat and Oranje murder Spain...this has a horror show Full moon Friday the 13th nightmare for NY written all over it.....then again, triple OT would be fun too Triple OT?
(8) Had they bothered to inquire of a veteran from the ranks, they might have heard how exasperating it is to see the dainty long-range patriots of Labour thrashing it out with the staunch gutter jingoists of the Conservative party – and barely a non-commissioned vet among them.
(9) Courtney Love recently had some of the SuicideGirls on her MTV special, while 70 of them featured in the video for the latest offering from Dave Grohl's thrash metal side-project, Probot.
(10) During talks to thrash out his reform package on Wednesday, treasury minister Giulio Tremonti reportedly told Berlusconi that he was Italy's real problem.
(11) Previously it only had to move refugees towards Macedonia; now it has to address their cases directly, and potentially house them for days or weeks while logistics with Turkey are thrashed out.
(12) Some analysts interpreted the Kenyan atrocity as a sign of weakness, the thrashings of a dying animal.
(13) At the inaugural meeting of the Human Brain Project earlier this month, researchers from more than 80 European institutions converged on the Lausanne campus to thrash out who would contribute to what platform.
(14) Arsenal will be Everton’s opponents in Saturday night’s final after they thrashed a Singapore XI 4-0 .
(15) Details of the property tax and water rates have also been thrashed out with the IMF, which is in favour of restricting extra income taxes in favour of higher taxes on consumption and wealth Mass meetings in Dublin have drawn protesters from across the country and several prominent members of the Irish and European parliaments.
(16) They leave the Tories relieved, Labour saying it could have been worse, Ukip alive if going nowhere and the Liberal Democrats barely out of their concussion from last year’s election thrashing.
(17) I don’t think he got a fair trial, but that is something we will have to thrash out at appeal,” Robinson told the Guardian, after giving a seminar on the case to law students at Nottingham University on Thursday night.
(18) There’s a lot we can take from them.” For now, all they have to show for brushes with Spurs is a pair of sound thrashings, and eight goals shipped en route, and it has been Kane who has revelled in the fixture most of all.
(19) I had seen the intriguingly named Millbrook Proving Ground on Top Gear, when Jeremy Clarkson et al thrashed some trucks around its 45 miles of twisty track.
(20) BAE and EADS are working to a deadline of 10 October deadline to thrash out a deal.