(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
(1) The hostility Said encountered from pro-Israeli circles in New York was predictable, given his trenchant attacks on Israeli violations of the human rights of Palestinians and his outspoken condemnations of US policies in the Middle East.
(2) He went with a bang not a whimper: two of his last contributions to the New Republic were a trenchant critique of the history of the six-day war by Michael Oren, now Israeli ambassador to Washington, and an evisceration of Koba the Dread, Martin Amis's purported book on Stalin.
(3) Yet with growing numbers of civilian deaths and escalating violence, many British Syrians have become more trenchant in putting forward pro- or anti-regime views.
(4) This year she won plaudits from fellow peers and disability activists alike over a series of trenchant interventions on the controversial welfare reform bill .
(5) "If there is one thing that has been wrong with this World Cup it is Fifa’s ridiculous insistence that teams wear predominantly light or dark strips," begins Stewart Todd, before taking a deep breath and resuming his diatribe, utilising both the 'relentless' and 'trenchant' styles.
(6) Ruggie’s report was welcomed by Sharan Burrow, general secretary of the International Trade Union Confederation and a trenchant critic of the lack of progress by Qatar on the migrant workers issue.
(7) Jones told Turnbull that because he had had dinner with Palmer, a trenchant critic of Abbott, “people” were suggesting that “precisely because you have no hope ever of being the leader again – you have got that into your head, no hope ever – that because of that you are happy to chuck a few bombs around that might blow up Abbott a bit, that is what they are saying.” Turnbull replied that it was Jones who was undermining the Abbott government and “doing the work of the Labor party”, a charge not usually levelled at the Sydney announcer who is an ardent supporter of the prime minister.
(8) He was speaking to The Independent, which reports: Mr Fisher trenchantly defends those decisions made at the height of the crisis.
(9) That is not only because of McDonnell’s trenchant hard-left economic views, but also because of his combative approach.
(10) The White House, fearing the impact of a European disaster on Barack Obama's re-election campaign, is becoming more trenchant in its criticism of the eurozone and its demands of the Germans.
(11) Former centre-right president Nicolas Sarkozy was reported to have supplied his own trenchant critique, even as Brignoles voters were preparing to elect Lopez in the second round.
(12) The comments from Maria Hutchings, described by Lib Dems as a Sarah Palin figure for her trenchant views and tendency to speak off-message, provoked a storm of protest as political opponents and state-educated celebrities, said she had insulted state schools, including two local ones with glowing Ofsted reports.
(13) I don't for a minute accept the logic of reforms that put individuals in private debt to avoid public debt but even the most trenchant libertarian can find fault when those same reforms end up costing the Treasury more money.
(14) He chose to release a trenchantly-worded judgment, explaining why had made the initial ruling to keep the identity of the footballer secret, in which he concluded there was "ample reason not to trust" the young woman.
(15) For old hands at the negotiations, such as Yvo de Boer, a former Dutch civil servant and UN climate chief known for his trenchant views, the conferences have become trapped in an endless cycle of repeats.
(16) But Abbott’s trenchant opposition to the fund is seen as an impediment to any contribution.
(17) As a result, general inequality has been becoming more grievous with every year that passes, and without a bleat from the leaders of the party who once spoke up so trenchantly and characteristically for greater equality.
(18) Rival Palestinian groups have hailed the signing of a reconciliation agreement that could change the parameters of the search for Middle East peace, amid trenchant opposition from Israel.
(19) The faith-based failure to plan for the invasion’s aftermath, rightly damned in trenchant terms by Sir John, was the most catastrophic for the Iraqi people, and indeed for the British service personnel in harm’s way.
(20) He has been the most prominent of black British intellectuals since the 1960s, a prominent figure of the Open University and among the most trenchant critics of Thatcherism.