(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Stab
Definition:
(v. t.) To pierce with a pointed weapon; to wound or kill by the thrust of a pointed instrument; as, to stab a man with a dagger; also, to thrust; as, to stab a dagger into a person.
(v. t.) Fig.: To injure secretly or by malicious falsehood or slander; as, to stab a person's reputation.
(v. i.) To give a wound with a pointed weapon; to pierce; to thrust with a pointed weapon.
(v. i.) To wound or pain, as if with a pointed weapon.
(n.) The thrust of a pointed weapon.
(n.) A wound with a sharp-pointed weapon; as, to fall by the stab an assassin.
(n.) Fig.: An injury inflicted covertly or suddenly; as, a stab given to character.
Example Sentences:
(1) I ask a friend to have a stab at, “down at cafe that does us butties”, and he said: “Something to do with his ass?” “Whose arse?” He looked panicked.
(2) Dermot Kelly said: "The England Supporters Band is right up there with the vuvuzela for wanting to stab myself in the head with a fork."
(3) You could understand why the Met was frantic to find who had stabbed Rachel Nickell 49 times on Wimbledon Common while her screaming child looked on, but the case against Stagg was preposterous.
(4) Results indicate that 75% of the participating boys and 10% of participating girls had witnessed the shooting, stabbing, robbing, or killing of another person in their own lives.
(5) Stab wounds to the temporal fossa appear as a characteristic clinical entity.
(6) Many of the patients with stab wounds of the precordial chest (danger zone) had cardiac or major vascular injuries, and the mortality rate of them was high.
(7) Sigurdsson’s deep corner kick was headed back across goal by Borja and Fer, via a slight touch from Van der Hoorn, stabbed over the line.
(8) The multi-agency review of the circumstances leading up to the killing of the 16-year-old, who was fatally stabbed at Cults Academy, one of Scotland’s highest performing state schools, on 28 October 2015, also concluded that his death could have been avoided had those who knew that his killer carried weapons in school reported this to staff.
(9) Later, it proved that he was stabbed with a foreign body penetrating into the contralateral frontal lobe through the left nasal cavity.
(10) Violence had subsided by Sunday evening – but not before dozens had been shot or stabbed, leaving 25 dead and 56 injured.
(11) It consists of the comprehensive extraction of the varices through extremely small stab incisions, followed immediately by vigorous marching.
(12) It is possible that Clegg could yet get to 30 seats or so at the next election, and in Britain's fluid politics that may give him a stab at forming another coalition.
(13) Another Palestinian man, suspected of having stabbed and wounded an Israeli teenager, was shot dead by police in Jerusalem.
(14) Based on one-to-one interviews with more than 40 people, the inquiry said the immediate aftermath of the stabbing “was well managed by all agencies”.
(15) Overall mortality was 130, 8.7%; 9.5% for gunshot wounds, 3.4% for stab wounds, and 2.5% for blunt trauma.
(16) I got to HaHagana bridge with a friend and we saw a big man in a red sweatshirt stabbing a soldier twice, apparently someone from the air force,” he said.
(17) On the other hand, both blunt trauma and posterior stab wounds frequently caused isolated retroperitoneal duodenal lesions where the diagnosis was not evident on admission, but in which the insidious and progressive development of symptoms and signs drew attention to the need for laparotomy.
(18) A patient who sustained an acute carotid-cavernous fistula due to a stab wound is presented.
(19) The use of the Columbia agar stab culture is recommended as a rapid and simple test for recognition of group B streptococci.
(20) If so, ministers may need to be prepared for a new breed of civil servants, who will no longer fall on their swords if they believe they have been stabbed in the back.