(n.) Transgression of the law of God; disobedience of the divine command; any violation of God's will, either in purpose or conduct; moral deficiency in the character; iniquity; as, sins of omission and sins of commission.
(n.) An offense, in general; a violation of propriety; a misdemeanor; as, a sin against good manners.
(n.) A sin offering; a sacrifice for sin.
(n.) An embodiment of sin; a very wicked person.
(n.) To depart voluntarily from the path of duty prescribed by God to man; to violate the divine law in any particular, by actual transgression or by the neglect or nonobservance of its injunctions; to violate any known rule of duty; -- often followed by against.
(n.) To violate human rights, law, or propriety; to commit an offense; to trespass; to transgress.
Example Sentences:
(1) Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels.
(2) These results support a hypothesis which proposes that ancestral SIN virus diverged into two distinct groups.
(3) Our studies show that SIN-1 and C87-3754 exert beneficial effects in a 6-h model of myocardial ischemia-reperfusion.
(4) Antibodies to all viruses were detected, and namely in these frequencies: SIN 0.9%, WN 16.9%, TAH 41.5%, CVO 23.1% and TBE 8.5%.
(5) As the later Spark might have said, a mortal sin against the commandment to love beauty wherever one may find it.
(6) The direct acting stimulants of soluble guanylate cyclase, sodium nitroprusside and SIN-1 (3-morpholino-sydnonimine), also increased the cGMP content of endothelial cells by 9.4 and 7.2 times, respectively.
(7) In superfused precontracted strips of rabbit aorta, methylene blue (MeB) or pyocyanin (Pyo, 1-hydroxy-5-methyl phenazinum betaine) at concentrations of 1-10 microM inhibited relaxations induced by endothelium-derived relaxing factor (EDRF), glyceryl trinitrate (GTN), S-nitroso-N-acetyl-penicillamine (SNAP) or 3-morpholino-sydnonimine (SIN-1).
(8) The likes of almond, blackberry and crocus first made way for analogue, block graph and celebrity in the Oxford Junior Dictionary in 2007, with protests at the time around the loss of a host of religious words such as bishop, saint and sin.
(9) These prostanoids were measured in platelets and endothelial cells alone or during their interaction, in the absence or presence of SIN-1.
(10) The haemodynamic effects of N-carboxy-3-morpholino-sydronimine-ethylester (molsidomine, SIN 10, Corvaton) were studied in anaesthetized mongrel dogs.
(11) The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats.
(12) Ten women with SIN were bilaterally salpingectomized.
(13) Analysis of the relationship between the pharmacodynamics and pharmacokinetics of SIN-1 suggests that an active metabolites is involved.
(14) The guanidine 3', 5'-cyclic monophosphate (cGMP) content (an index of EDRF production) was determined by radioimmunoassay under basal conditions and after acetylcholine (10(-5) M), bradykinin (10(-5) M) and SIN-1 (10(-4) M) stimulation.
(15) sin- mutants (defining six genes) were identified because they express HO in the absence of particular SWI products.
(16) We studied the effects of intracoronary injections of SIN-1 (0.8 mg), the active metabolite of molsidomine, on coronary artery diameters and coronary stenoses.
(17) Sessions included "naming the sin, lifting the shame" and "normal sinfulness or a sickness".
(18) The nitric oxide donor compound, 3-morpholinosydnonimine (SIN-1), was equipotent at relaxing the central and peripheral airways.
(19) Oxyhaemoglobin used for the assay of NO, inhibited the relaxation by SIN-1, but did not reduce vessel relaxations induced by GTN or iloprost, a stable prostacyclin analogue.
(20) A degraded SIN-1 solution that did not release NO was unable to block NMDA receptors.
Sis
Definition:
(n.) A colloquial abbreviation of Sister.
(n.) Six. See Sise.
Example Sentences:
(1) Chromatographic separation revealed that the bulk (85%) of the mitogenic activity in SSV-transformed NRK cells was not due to p28v-sis but rather two distinct endothelial cell growth factors that eluted off heparin-Sepharose between 1 and 2 M NaCl.
(2) To get an insight into the nature of variant Ph translocations and the process of their formation, we examined the localization of the c-abl and c-sis oncogenes and the breakpoint cluster region (bcr) gene by chromosomal in situ hybridization in ten variant Ph translocations of CML including five simple and five complex ones as initially interpreted.
(3) Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients.
(4) Cells transformed by v-sis produce a platelet-derived growth factor-related molecule which is able to stimulate the platelet-derived growth factor receptor in an autocrine fashion.
(5) The v-sis oncogene of simian sarcoma virus (SSV) is a retroviral version of the PDGF B chain gene and SSV-transformation is mediated by an autocrine PDGF-like growth factor.
(6) Messenger RNA levels for v-sis were induced by tension in intact but not denuded vessels.
(7) In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells.
(8) First, we investigated the expression of c-sis protooncogenes within cultured human glioma cell lines and also fresh glioma specimens by using polymerase chain reaction.
(9) The v-sis gene encodes chain B of platelet-derived growth factor.
(10) However, in tissue adjacent to 5 different tumors, approximately the same level of c-sis mRNA was seen.
(11) c-sis mRNA levels diminished with increased time of infection.
(12) For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates.
(13) SIS SVB was performed to a variety of vessel combinations using "Y" graft, continuous, or vein extension techniques achieving early patency in all limbs, despite pedal arch disease.
(14) Radiolabeled recombinant PDGF (c-sis) dissociated from Heparin-Sepharose within a concentration range of NaCl similar to that of RF I.
(15) increased cell size, reduced growth rate, megakaryocytic antigens, and expression of the sis proto-oncogene, the structural gene for the B-chain of platelet-derived growth factor.
(16) In human malignant mesothelioma cell lines elevated expression of the platelet-derived growth factor (PDGF) beta-chain (c-sis) gene was previously reported, while normal mesothelial cells barely express this gene.
(17) The same temporal dissociation was observed when a recombinant v-sis product was used instead of porcine PDGF.
(18) Reduced function of runt results in female-specific lethality and sexual transformation of XX animals that are heterozygous for Sxl or sis loss-of-function mutations.
(19) Several specific related questions are addressed in this discussion: Is the protein encoded by the v-sis gene functionally identical to PDGF?
(20) This suggests that H-ras is less efficient in relieving the insulin requirement than is sis.