(1) Lethargy and somnolence were reported on both capsule and tablet by several subjects at a time which corresponded with the maximum concentration of drug in plasma.
(2) On admission, the patient's state of consciousness deteriorated from somnolence to coma.
(3) This was generally mild and always fully reversible and consisted mainly of forgetfulness, occasionally hallucinations, nightmares and somnolence.
(4) A 63-year-old man was admitted to our hospital with tremor and somnolence, followed soon by coma.
(5) Diminished salivary flow was significantly greater with amitriptyline, as were complaints of dry mouth, somnolence, dizziness, and headache.
(6) Somnolence, hypotonia, weight gain, excitation, and insomnia were the most common problems at the beginning of the study and were usually transient.
(7) A 60-year-old woman who for many years had been taking salicylate-containing tablets for headaches, was admitted to hospital, in a somnolent state, because of increasing weakness, tiredness, memory and speech disorders, and tinnitus.
(8) The central anticholinergic syndrome (CAS) includes central signs (somnolence, confusion, amnesia, agitation, hallucinations, dysarthria, ataxia, delirium, stupor, coma) and peripheral signs (dry mouth, dry skin, tachycardia, visual disturbances and difficulty in micturition).
(9) During three month periods, the patient progressively became somnolent, speechless and immobile.
(10) Our data demonstrate that patients with diagnosable disorders of excessive somnolence may be discordant on the two tests (eg, having low sleep latency on MSLT but high sleep latency on MWT).
(11) Tolerance was good with the rare problem of somnolence.
(12) Neurological examination on admission revealed somnolence and right-hemiparesis.
(13) The clinical features include overwhelming episodes of sleep, excessive daytime somnolence, hypnagogic hallucinations, disturbed nocturnal sleep; manifestations of dissociated REM sleep inhibitory process, cataplexy and sleep paralysis; and a special polygraphic pattern: the sleep onset REM episode.
(14) Symptoms of excessive daytime somnolence range from mild to severe.
(15) Subjects with a history of post-irradiation somnolence syndrome were significantly older at diagnosis than nonsomnolent subjects.
(16) In some cases there was a marked additional fall of arterial pressure in the orthostatic position, a sensation of dryness in the mouth, weakness and mild somnolence.
(17) The results indicate that inattention and somnolence negatively influence memory performance and should be taken into account when evaluating the Amytal memory test results.
(18) Clinical symptoms include excessive daytime somnolence, overwhelming daytime sleep episodes, attacks of cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed nocturnal sleep; sleep onset REM episodes are the main polygraphic feature.
(19) Patients with the hypersomnia-sleep apnea syndrome should be provided with a tracheal opening during sleep when severe daytime somnolence, cardiac arrhythmias, and hypertension are present.
(20) The decreased somnolence and increased libido and potency which accompanied therapy with levodopa suggest damage to dopaminergic and noradrenergic pathways.
(a.) Causing sleep; tending to cause sleep; soporiferous; as, the soporific virtues of opium.
(n.) A medicine, drug, plant, or other agent that has the quality of inducing sleep; a narcotic.
(1) The maximum soporific effect did not occur until 90-120 s after injection.
(2) His answer threatened a soporific summer-long contest that would expose a great gap between the self-styled people's party and the people themselves.
(3) 'P ublic sector commissioning": I can't think of a phrase that conveys something so important and yet sounds so soporific.
(4) Soporific effect of hexenal was distinctly increased in the burns, which correlated to the severity of thermic impairment.
(5) Pebble-dashed walls, red roof tiles, Velux windows, cherry trees... these things make me think not of daring strokes of oil on canvas, but of the safe, the soporific - a round of golf, perhaps, or a gentle Sunday-night sitcom.
(6) Less drugs were used in general, and the use of tranquillizers and soporifics was cut down to a third.
(7) Higher doses of naloxone (1Opmol into the LC) were however, required to antagonize the behavioural and ECoG soporific effects induced by the Kappa-receptor agonist U 50,488H.
(8) The drug is well tolerated by the patients and does not produce any inhibitory or soporific action.
(9) And, intriguingly, a 2009 study at Mashhad University in Iran revealed an extract of saffron did have soporific qualities, on mice at least.
(10) Instead, the atmosphere is soporific, with an underlying threat of menace.
(11) Toxicological urine analysis for drugs--directed mainly at soporifics, sedatives, tranquilizers, and pain-relievers--on 84 patients involved in industrial accidents yielded the following results.
(12) What had been a sombre occasion for City fans as they looked at an Etihad Stadium dugout without Mancini for a first time since December 2009 became further muted when a soporific start to the game had ended with Anthony Pilkington opening the scoring for Norwich.
(13) 1 Experiments were performed on a variety of tissues from different species to establish whether or not the properties of p-chlorophenylalanine methyl ester (PCPA) included a 5-hydroxytryptamine (5-HT)-like action which might explain the soporific action of PCPA in chicks.
(14) Because of their pharmacologic action, alcohol and high doses of soporifics used as remedies may produce REM-deficit sleep and actually prolong insomnia.
(15) Imagine my surprise in the morning to find it was gone 7am – the soporific effect of the loud snoring made my baby sleep through the night for the first time!
(16) Long sleep (LS) and short sleep (SS) mice have a differential sensitivity to the behavioral actions of an adenosine agonist, R-phenylisopropyl-adenosine (PIA) that parallels their differential sensitivity to the soporific effects of ethanol.
(17) If so, the soporific way Per Mertesacker dawdled in possession and Kieran Gibbs clumsily punted the ball into the air suggested there had been scant impact.
(18) After 53 days of alcohol ingestion there was no evidence of tolerance to the soporific effects of parenterally administered ethanol and removal of the ethanol solutions failed to produce any signs of alcohol withdrawal.
(19) Further, much evidence also supports the conclusion that most of these hypnotic-depressants and anesthetics could exert their soporific influence by a potentiation of GABA activity.
(20) Recent evidence, as well as reevaluated previous evidence, indicates that Long-Sleep mice are more sensitive to the soporific effects of three major classes of CNS depressants (alcohols, barbiturates, and benzodiazepines), as well as many other anesthesia-inducing compounds (adenosine, chloral hydrate, trichloroethanol, paraldehyde, nitrous oxide, enflurane, and isoflurane).