(1) Whether or not there were carriers for either amorphous or hypomorphous alleles of the SORD locus in the population studied could not be defined in terms of enzymatic activity levels.
(2) Each plasmid contained the structural genes sorA for an Enzyme II of the phosphoenolpyruvate-dependent carbohydrate:phosphotransferase system, sorD for a D-glucitol 6-phosphate dehydrogenase, sorE for an L-sorbose 1-phosphate reductase, and the corresponding regulator gene sorR.
(3) New descriptions of three species and one subspecies of larvae of T. semenovi Ols., T. regularis Jaenn., T. laetetinctus laetetinctus Beck., and T. l. sordes Bog.
(4) Biochemical studies showed that thiol groups participate in the mobility of the SP fast band; furthermore, an interchange of the bands of SP-SORD was observed which suggests that the isozymes are due to conformational isomerism or to molecular aggregates.
(5) An electrophoretic study of sorbitol dehydrogenase (SORD) in sperm and seminal plasma (SP) was realized.
(6) In SP, three phenotypes (one slow band, one fast, and both bands) were observed, corroborating the electrophoretic variability of SP-SORD formerly reported by us, while, in sperm, SORD showed a phenotype of one band faster than the one of SP.
(7) The structural genes sorD, sorA and sorE code for a D-glucitol-6-P dehydrogenase (27 kilodalton (kD)), an Enzymell (EllSor) activity specific for L-sorbose and an L-sorbose-1-P reductase (45kD).
(8) The chromosomal locations for these 23 loci were determined as follows: GOT1 on rat chromosome 1; HAGH on 2; ACP2, ADA, GANC, ITPA, and SORD on 3; LDHB on 4; PEPB on 7; GLB1 and HEXA on 8; IDH1 on 9; UMPH2 on 10; GUSB on 12; FH and PEPC on 13; PEPS on 14; ESD and NP on 15; DIA4 on 19; and PP on 20.
(9) The linkage of NP, IDH2, SORD, MPI, and PKM2 was confirmed, and three other independently segregating markers (MDH1, ACY1, and PEPB) were identified.
(10) A wide variability in RBC-SORD activity in controls and patients was observed.
(11) They form an operon (gene order sorCpCDFBAME) inducible by L-sorbose, and their products have the following functions: SorC (36 kDa), regulatory protein with repressor-activator functions; SorD (29 kDa), D-glucitol-6-phosphate dehydrogenase; SorF and SorB (14 and 19 kDa, respectively), and SorA and SorM (27 and 29 kDa, respectively), two soluble and two membrane-bound proteins, respectively, of an L-sorbose phosphotransferase transport system; SorE (45 kDa), sorbose-1-phosphate reductase.
(12) A screening for both thermostability and electrophoretic red blood cell sorbitol dehydrogenase (RBC-SORD) variants in blood donors was performed.
(13) A computer program was developed for on-line analysis of nystagmus parameters using a microcomputer (SORD M243EX).
(14) Of the 15 loci, three genes, HK1, PEPC, and SORD, were newly assigned to chromosomes 1, 5, and 6, respectively, while ENO1, PGD, and PGM1 were assigned to the long arm of chromosome 2, in the segment 2q113----qter.
(15) Quantitative screening for red blood cell sorbitol dehydrogenase (RBC-SORD) deficiency in 111 patients with juvenile onset diabetes, 92 patients with adult onset diabetes, 42 patients with idiopathic cataracts and 192 professional blood donors was performed.
(16) Linkage group 3 comprises PEP-B (peptidase B), MPI-1 (mannosephosphate isomerase), SORD (sorbitol dehydrogenase), and mIDH-2 (mitochondrial isocitrate dehydrogenase).
(17) No significant differences in SORD activity either between patients with diabetes and patients with idiopathic cataracts or between diabetics with and without cataracts were observed.
Surd
Definition:
(a.) Net having the sense of hearing; deaf.
(a.) Unheard.
(a.) Involving surds; not capable of being expressed in rational numbers; radical; irrational; as, a surd expression or quantity; a surd number.
(a.) Uttered, as an element of speech, without tone, or proper vocal sound; voiceless; unintonated; nonvocal; atonic; whispered; aspirated; sharp; hard, as f, p, s, etc.; -- opposed to sonant. See Guide to Pronunciation, //169, 179, 180.
(n.) A quantity which can not be expressed by rational numbers; thus, Ã2 is a surd.