(a.) Liable to break or split; brittle; as, spalt timber.
(a.) Heedless; clumsy; pert; saucy.
(a.) To split off; to cleave off, as chips from a piece of timber, with an ax.
Example Sentences:
(1) The region-specific homeotic gene spalt (sal) acts in two separate domains in the head and tail region of the Drosophila melanogaster embryo.
(2) The expression of this newly discovered gene, spalt major (salm) is strongly repressed in gain-of-function mutants that express Antp in the antennal disc.
(3) Rhabdomyolysis without renal failure was noted after suicidal ingestion of 29 tablets of Spalt N containing 7.25 g of acetaminophen, 7.25 g of phenazone and 1.45 g of caffeine by a 29 year-old weighing 73 kg.
(4) The differences in the SPALT method can be ascribed to the possibility that this assay measures not only "intact" caeruloplasmin but also paraneoplastic substances with "caeruloplasmin-like immunoactivity".
(5) The enhancer detector in this strain is located near a similarly regulated gene at the spalt (sal) locus, which encodes a homeotic function involved in embryonic head and tail development.
Splotch
Definition:
(n.) A spot; a stain; a daub.
Example Sentences:
(1) The Splotch mutant embryo is proposed to be a new animal model for the study of peripheral nerve ensheathment.
(2) Concurrent research has recently characterized Sp2H, a radiation induced mutation at the splotch (Sp) locus, and found alterations in the murine paired box gene, Pax-3, in homozygous Sp2H DNA.
(3) The early development of delayed Splotch mouse embryos was examined histologically using scanning electron microscopy and morphometric techniques.
(4) Studies with the delayed splotch gene tested the hypothesis that offspring with a hereditary defect of neural-tube closure have other, unexpressed CNS defects, which may be elicited by teratological impulses.
(5) Yet grisly pictures on Xinhua's website show a shirtless man covered in purple splotches lying on a hospital bed, his left arm awkwardly splayed across his chest.
(6) The topogenesis of the hindlimb nerves of Splotch homozygous mutant mouse embryos was studied using light and electron microscopy.
(7) Sp1H mice, which have a radiation-induced allele of Splotch with a similar phenotype, were used for this study.
(8) We have used a set of markers newly assigned to the proximal portion of mouse chromosome 1 to characterize the chromosomal segment deleted in the splotch-retarded (Spr) mouse mutant.
(9) A major problem in the study of neural tube defects caused by the splotch (Sp) gene in the mouse has been the identification of gene carriers or potentially affected embryos at an early stage of development, since the gene's effects become visible only late in gestation or after birth.
(10) The splotch (Sp) mouse is a model for both neurulation defects and defects in neural crest cell (NCC) derivatives.
(11) The parameters of the cell cycle were determined in 10-day-old mouse embryos, homozygous for the splotch (Sp) gene, by the radioautographic method with H-3-thymidine.
(12) In this report, rare cases of neural tube defects and tail defects among the offspring of crosses between Splotch (Sp1H) heterozygotes are presented, which are not associated with a neural crest defect.
(13) The Splotch mutant mouse is proposed to be an animal model for persistent truncus arteriosus.
(14) Embryos carrying Sp or its allele splotch-delayed (Spd), have been shown to have delays in neural tube closure, and neural crest cell emigration, as well as a reduction in extracellular space around the neural tube.
(15) In the homozygous state, the splotch (Sp) gene causes spina bifida and exencephaly.
(16) By the 12th day, the posterior neuropore of controls had closed and secondary neurulation was underway; however in delayed Splotch embryos, the neural folds remained widely splayed and epithelium newly formed via secondary neurulation extended that abnormally open configuration to the tip of the tailbud.
(17) Splotch is caused by mutation in the mouse Pax-3 gene.
(18) The septation of the truncus arteriosus and the development of the aortic arch-derived blood vessels was studied in homozygotes of the Splotch mutant allele Sp1H.
(19) Mouse embryos, homozygous for mutations at the Splotch locus, are afflicted with spina bifida and disturbances of neural-crest-derived tissues, e.g.
(20) Embryos obtained from matings of mice heterozygous for the delayed Splotch gene exhibited a high incidence of lumbosacral (25%) or cephalic (7%) neural tube defects.