(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.
Wide
Definition:
(superl.) Having considerable distance or extent between the sides; spacious across; much extended in a direction at right angles to that of length; not narrow; broad; as, wide cloth; a wide table; a wide highway; a wide bed; a wide hall or entry.
(superl.) Having a great extent every way; extended; spacious; broad; vast; extensive; as, a wide plain; the wide ocean; a wide difference.
(superl.) Of large scope; comprehensive; liberal; broad; as, wide views; a wide understanding.
(superl.) Of a certain measure between the sides; measuring in a direction at right angles to that of length; as, a table three feet wide.
(superl.) Remote; distant; far.
(superl.) Far from truth, from propriety, from necessity, or the like.
(superl.) On one side or the other of the mark; too far side-wise from the mark, the wicket, the batsman, etc.
(superl.) Made, as a vowel, with a less tense, and more open and relaxed, condition of the mouth organs; -- opposed to primary as used by Mr. Bell, and to narrow as used by Mr. Sweet. The effect, as explained by Mr. Bell, is due to the relaxation or tension of the pharynx; as explained by Mr. Sweet and others, it is due to the action of the tongue. The wide of / (/ve) is / (/ll); of a (ate) is / (/nd), etc. See Guide to Pronunciation, / 13-15.
(adv.) To a distance; far; widely; to a great distance or extent; as, his fame was spread wide.
(adv.) So as to leave or have a great space between the sides; so as to form a large opening.
(adv.) So as to be or strike far from, or on one side of, an object or purpose; aside; astray.
(n.) That which is wide; wide space; width; extent.
(n.) That which goes wide, or to one side of the mark.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(3) In this paper, we show representative experiments illustrating some characteristics of the procedure which may have wide application in clinical microbiology.
(4) Although antihistamines are widely used for symptomatic treatment of seasonal (allergic) rhinitis, the role of histamines in the pathogenesis of infectious rhinitis is not clear.
(5) When the data correlating DHT with protein synthesis using both labelling techniques were combined, the curves were parallel and a strong correlation was noted between DHT and protein synthesis over a wide range of values (P less than 0.001).
(6) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(7) Migrant voters are almost as numerous as current Ukip supporters but they are widely overlooked and risk being increasingly disaffected by mainstream politics and the fierce rhetoric around immigration caused partly by the rise of Ukip,” said Robert Ford from Manchester University, the report’s co-author.
(8) Matthias Müller, VW’s chief executive, said: “In light of the wide range of challenges we are currently facing, we are satisfied overall with the start we have made to what will undoubtedly be a demanding fiscal year 2016.
(9) Breast conserving surgery in patients with small tumors combined with radiation therapy has gained wide popularity due to better cosmetic results without significant changes in survival.
(10) There are no oceans wide enough to stop us from dreaming.
(11) According to the national bank, four Russian banks were operating in Crimea as of the end of April, but only one of them, Rossiisky National Commercial Bank, was widely represented, with 116 branches in the region.
(12) It is widely seen as a counter to China’s economic might in Asia, and the world’s second largest economy is notably absent from the list of signatories.
(13) I wish to clarify that for the period 1998 to 2002 I was employed by Fifa to work on a wide range of matters relating to football,” Platini wrote.
(14) Label was found widely distributed among all the organs except the nervous system and its rate of disappearance from the tissues paralleled its disappearance from the circulation.
(15) Widely varying numbers of endocrine cells were identified in 12 out of 64 cases of uterine cancer in the course of histochemical and electron microscopic examination.
(16) These sera were derived from children with a wide range of tumor types.
(17) The results, together with the known geometry of the enzyme, indicate that active site probes in the dodecamer are widely separated and that energy transfer occurs from a single donor to two or three acceptors on adjacent subunits.
(18) We therefore conclude that widely spaced (and unknown) parts of the protein chain are required for the intersubunit interactions that eventually lead to functional assembly of the receptor.
(19) Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution.
(20) Second, the nurse must be aware of the wide range of feeling and attitudes on specific sexual issues that have proved troublesome to our society.