(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Tin
Definition:
(n.) An elementary substance found as an oxide in the mineral cassiterite, and reduced as a soft white crystalline metal, malleable at ordinary temperatures, but brittle when heated. It is not easily oxidized in the air, and is used chiefly to coat iron to protect it from rusting, in the form of tin foil with mercury to form the reflective surface of mirrors, and in solder, bronze, speculum metal, and other alloys. Its compounds are designated as stannous, or stannic. Symbol Sn (Stannum). Atomic weight 117.4.
(n.) Thin plates of iron covered with tin; tin plate.
(n.) Money.
(v. t.) To cover with tin or tinned iron, or to overlay with tin foil.
Example Sentences:
(1) Hollywood legend has it that, at the first Academy awards in 1929, Rin Tin Tin the dog won most votes for best actor.
(2) Facebook Twitter Pinterest Without the money to begin building permanent homes, residents of Barkobot are living in temporary tin shacks.
(3) A knee simulator was used to study the wear of carbon fiber reinforced UHMWPE (Poly Two) (Poly Two is a registered trademark of Zimmer, USA) tibial and patellar components against Ti-6A1-4V, titanium nitride (TiN)-coated Ti-6A1-4V, and cobalt-chromium-molybdenum femoral components.
(4) It's a small sample, consisting of the folk on the train to Kings Cross this lunchtime, but your MBM correspondent saw: several gentlemen swilling from cans of San Miguel and talking excitedly about the World Cup; two blonde women in frankly disorienting 1980s style football shorts waving flags; and a bloke sitting on his own necking a tin of pre-mixed gin and tonic.
(5) The Meikhtila district chairman, Tin Maung Soe, said one Buddhist man was sentenced to five years' imprisonment on Thursday for causing grievous harm in connection with the killing of two Muslim men.
(6) FreeKachin (@FreeKachin) Nov 10, 5pm, attached object fell off of the sky at Tin Aung Kyaing mining lot in Hpakant Jade tract.
(7) To measure the degree of wetting of the metallic phases, silver, tin, and copper were melted in such proportions as to give specimens of silver, tin, the alpha, beta, and gamma silver-tin phases, the eutectic in the silver-copper system.
(8) Designed seven years ago by Foggo Associates , the 24-storey spam tin has been revived by one of the world’s biggest pension funds, TIAA-CREF.
(9) Logging, cattle farming and soy plantations are key, plus the increased construction of dams and road, and shifting patterns of farming for local people and mining (for diamonds, bauxite, manganese, iron, tin, copper, lead and gold).
(10) The calcium binding activity in the soluble fraction of renal cortex increased significantly at any of the time intervals between 6 and 72 hr after administration of tin, and this increase preceded an elevation of the calcium concentration in the renal cortex.
(11) Comparison of the data from the tin-fed groups with both the control and the reduced diet groups allowed discrimination between effects of reduced feed intake and Sn2+ effects.
(12) Critical verdict The Tin Drum catapulted Grass to the forefront of European fiction and since then he has been Germany's "permanent Nobel candidate"; of the remainder of the Danzig trilogy, Cat and Mouse is the best regarded.
(13) Wearing a white dress, black jacket and patent leather sandals, and clutching her mobile phone and keys, she could be on her way to an office in one of the capital's new skyscrapers, instead of walking past a patchwork of bean and sweet potato fields en route to the village's tin-roofed administration offices.
(14) Lead and tin concentrations in the blood were estimated.
(15) Because of the tin effect 99mTc-DTPA or 99mTc-citrate should be used for brain scintigraphy if this has to be performed within the first 5 or 7 days following a bone scintigraphy with a tin-containing radiopharmaceutical.
(16) Webb agreed, calling Miliband "irresponsible" for "stirring up cheap headlines", sneering: "Why doesn't the government set a price cap on a tin of beans?"
(17) Of the metalloporphyrins examined (Fe, Co, Zn and Sn) all inhibited ferrochelatase at micromolar concentrations, although tin protoporphyrin was the least effective.
(18) This procedure gives the silver-tin amalgam the bactericidal characteristics of a copper amalgam but essentially higher marginal strength.
(19) Jasmin Lorch, from the GIGA Institute of Asian Studies in Hamburg, said: “If the military gets the feeling that its vested interests are threatened, it can always act as a veto player and block further reforms.” The New York-based advocacy group Human Rights Watch said the elections were fundamentally flawed, citing a lack of an independent election commission with its leader, chairman U Tin Aye, both a former army general and former member of the ruling party.
(20) At the beginning of his career, Moreno as Freud, found himself in a transcultural position which allowed him to better observe the "classical occidental individual" captive of his stereotypal "Tinned culture".